本文選題：鼻咽癌 + EB病毒��； 參考：《復(fù)旦大學(xué)》2011年碩士論文

【摘要】：鼻咽癌(nasopharyngeal carcinoma, NPC)是我國(guó)常見的惡性腫瘤之一,具有很明顯的地域特征。我國(guó)南方的珠江三角洲是鼻咽癌的高發(fā)區(qū),而上海則處于高發(fā)與低發(fā)之間。 EB病毒(Epstein-Barr virus, EBV)屬于人類γ皰疹病毒,是一種人類普遍感染的嗜B淋巴細(xì)胞病毒。目前認(rèn)為,EB病毒感染與鼻咽癌密切相關(guān),但EB病毒感染者中只有少數(shù)會(huì)發(fā)生鼻咽癌。由于EB病毒感染的普遍性及地域傾向性,有必要研究不同地區(qū)EB病毒感染與鼻咽癌的關(guān)系。 本研究收集了206例病理學(xué)證實(shí)的未經(jīng)治療的鼻咽癌患者和325例健康成人的血清,均采用ELISA(酶聯(lián)免疫吸附試驗(yàn))法定量檢測(cè)血清中的Rta/IgG、EBNA1/IgA、VCA/IgA等抗體水平。評(píng)估EB病毒抗體Rta/IgG、EBNA1/IgA、VCA/IgA的檢測(cè)對(duì)上海地區(qū)鼻咽癌患者的臨床價(jià)值。 206例鼻咽癌病人的EB病毒抗體Rta/IgG、EBNA1/IgA、VCA/IgA的敏感度分別為64.08%、88.35%、86.89%；特異度分別為92.62%、92.92%、95.69%；三種抗體同時(shí)陽性的模式在鼻咽癌病人中出現(xiàn)的概率最高(55.83%),而在正常對(duì)照組中無一例出現(xiàn)。 結(jié)果表明,上海地區(qū)EB病毒感染與鼻咽癌密切相關(guān)。EB病毒抗體Rta/IgG、EBNA1/IgA、VCA/IgA的聯(lián)合檢測(cè)對(duì)上海地區(qū)鼻咽癌病人的診斷具有參考價(jià)值。
[Abstract]:Nasopharyngeal carcinoma (NPC) is one of the most common malignant tumors in China. The Pearl River Delta in southern China is a high incidence area for nasopharyngeal carcinoma, while Shanghai is between high and low incidence. Epstein-Barr virus (EBV) is a human gamma-herpesvirus, which is a common human B lymphocyte virus. It is believed that Epstein-Barr virus (EBV) infection is closely related to nasopharyngeal carcinoma (NPC), but only a few of EBV infected patients have NPC. Because of the prevalence and geographical tendency of EBV infection, it is necessary to study the relationship between EBV infection and nasopharyngeal carcinoma in different regions. The sera of 206 pathologically proved patients with nasopharyngeal carcinoma and 325 healthy adults were collected. Elisa was used to determine the level of RTA / IgGN 1 / 1 / IgAVCA / IgA in the serum of patients with nasopharyngeal carcinoma (NPC) and 325 healthy adults (n = 325) by Elisa (enzyme linked Immunosorbent Assay (Elisa). To evaluate the clinical value of EBNA1 / VCA-IgA in NPC patients in Shanghai. The sensitivity of EBNA1 / VCA-VCA-IgA in 206 NPC patients was 64.08% 88.35%, and the specificity was 92.622% 92.922% and 95.6969%, respectively, in 206 patients with nasopharyngeal carcinoma, the sensitivity of EBNA1% IgA / VCA / IgA was 64.08%, and the specificity was 92.622% 92.922% and 95.69%, respectively. The three antibody positive patterns were most likely to occur in NPC patients (55.83%), but none in normal controls. The results showed that EBV infection in Shanghai area was closely related to nasopharyngeal carcinoma. The combined detection of EB virus antibody Rta-IgGna-EBNA1 / IgA / VCA / IgA has reference value for the diagnosis of nasopharyngeal carcinoma patients in Shanghai area.
【學(xué)位授予單位】：復(fù)旦大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2011
【分類號(hào)】：R739.63

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