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  本文選題：特發(fā)性黃斑裂孔 + 內(nèi)界膜染色��； 參考：《鄭州大學》2011年碩士論文

【摘要】：目的 比較亮藍(brilliant blue G, BBG)與吲哚菁綠(indocyanine green, ICG)輔助內(nèi)界膜染色治療特發(fā)性黃斑裂孔(idiopathic macular hole, IMH)的效果。 材料和方法 回顧分析2009年1月至2010年10月在我小組因特發(fā)性黃斑裂孔而接受玻璃體切除(par plana vitrectomy,PPV)聯(lián)合內(nèi)界膜(internal limiting membrane, ILM)剝離治療的患者。根據(jù)術前檢查,排除Ⅰ、Ⅱ期和術后因白內(nèi)障加重需行白內(nèi)障手術的黃斑裂孔,共有Ⅲ和Ⅳ黃斑裂孔44例(46只眼)。按術中內(nèi)界膜染色時使用的染色劑分為2組：20眼使用0.25%BBG染色(BBG組)；26眼使用0.25%ICG染色(ICG組)。比較兩組術中染色效果、剝膜率,術后兩組患者的裂孔閉合率、最佳矯正視力(best corrected visual acuity, BCVA)(術后3月時)等改變。 結(jié)果 兩組患者的年齡、術前最佳矯正視力無統(tǒng)計學意義(p0.05)。術中BBG或ICG使所有患眼ILM染色,均有效增加了ILM的可見度,染色率為100%。BBG將ILM染成淡藍色,ICG將ILM染成淡綠色,但后者染色效果更清晰。兩組均順利剝除ILM,剝除率為100%。兩組中除ICG組有1眼術后黃斑裂孔未閉合外,其余眼黃斑裂孔完全閉合。BBG組術后BCVA提高程度為0.46±0.08；ICG組術后BCVA提高程度為0.45±0.05,同術前相比視力明顯提高,差異均有統(tǒng)計學意義(p0.05)。分析兩組間的裂孔閉合率(p=0.926)和BCVA提高程度p=0.098)差異均無統(tǒng)計學意義(p0.05)。兩組病例均未發(fā)生嚴重手術并發(fā)癥。 結(jié)論 在特發(fā)性黃斑孔患者,0.25%BBG與0.25%ICG均使所有的ILM染色并剝離,染色率、剝膜率均為100%；兩組術后裂孔閉合率、BCVA提高程度無統(tǒng)計學差異。
[Abstract]:objective
The effect of brilliant blue G (BBG) and indocyanine green (indocyanine green, ICG) on the treatment of idiopathic macular hole (idiopathic macular hole, IMH) was compared with indocyanine green (ICG).
Materials and methods
A retrospective analysis was made of patients with par plana vitrectomy (PPV) combined with internal boundary membrane (internal limiting membrane, ILM) dissection in our group from January 2009 to October 2010. According to the preoperative examination, the macular holes in cataract surgery were eliminated in stage I, stage II and after cataract surgery. 44 cases (46 eyes) of macular hole (46 eyes) were divided into 2 groups according to intraoperative membrane staining: 20 eyes were stained with 0.25%BBG (group BBG); 26 eyes were stained with 0.25%ICG (group ICG). The staining effect, the stripping rate, the split hole closure rate of two groups of patients and the best corrected visual acuity (best corrected visual acuity, BCVA) were compared in the 26 eyes (group ICG). The change in March).
Result
The best corrected visual acuity before operation was not statistically significant in the two groups (P0.05). BBG or ICG during the operation made all eyes ILM dyed, which increased the visibility of ILM effectively. The staining rate was 100%.BBG, ILM was dyed light blue, ICG turned ILM into light green, but the latter dyeing effect was clearer. The two groups were all smoothly stripped of ILM and the stripping rate was I except I in 100%. two groups. In group CG, after 1 eyes, the macular hole was not closed, the other eye macular hole completely closed in group.BBG was 0.46 + 0.08 after operation, and the degree of BCVA improvement in group ICG was 0.45 + 0.05 after operation, and the visual acuity was significantly higher than that before operation. The difference was statistically significant (P0.05). The fracture closure rate (p=0.926) and BCVA improvement degree p=0.09 between the two groups were analyzed. 8) the difference was not statistically significant (P0.05). No serious operative complications occurred in the two groups.
conclusion
In the patients with idiopathic macular holes, both 0.25%BBG and 0.25%ICG were stained and stripped of all ILM, the rate of dyeing and the stripping rate were 100%, and there was no statistical difference between the two groups.
【學位授予單位】：鄭州大學
【學位級別】：碩士
【學位授予年份】：2011
【分類號】：R779.6

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