本文選題：喉腫瘤 + 因素分析　； 參考：《重慶醫(yī)科大學(xué)》2010年碩士論文

【摘要】： 目的:探討喉癌的自然生存率及其影響因素。 方法:回顧性分析2000年1月1日至2007年12月31日188例未行喉切除術(shù)及放化療治療的喉癌患者的臨床資料,包括年齡、吸煙史、腫瘤家族史、結(jié)核病史、腫瘤生長部位、病理學(xué)分級、T分期、N分期、臨床分期以及有無氣管切開術(shù)史。應(yīng)用Kaplan-Meier乘極限法計(jì)算生存率,單因素分析組間比較采用Log-rank檢驗(yàn),多因素分析采用Cox比例風(fēng)險(xiǎn)模型。 結(jié)果:總的中位生存時(shí)間為14±1.47月,1年、2年、5年生存率分別為54.7%、26.6%、11.0%;確診超過5年的病例(除失訪者外)尚無一例生存超過5年。0/Ⅰ/Ⅱ期中位生存時(shí)間為33±5.72月,1年、2年生存率分別為75.1%、57.9%;Ⅲ/Ⅳ期中位生存時(shí)間為10±1.31月,1年、2年生存率分別為43.2%、11.4%。單因素分析顯示腫瘤生長部位、病理學(xué)分級、T分期、N分期、臨床分期對生存率的影響有統(tǒng)計(jì)學(xué)意義(P0.05),而是否行氣管切開術(shù)無統(tǒng)計(jì)學(xué)意義。多因素分析顯示病理學(xué)分級、臨床分期對生存率的影響有統(tǒng)計(jì)學(xué)意義(P0.05)。 結(jié)論:喉癌自然病程發(fā)展較快,在未針對腫瘤本身治療的情況下,即便行姑息性手術(shù)如氣管切開術(shù)亦不能提高生存率;影響喉癌自然生存率的因素為腫瘤生長部位、病理學(xué)分級、T分期、N分期、臨床分期,其中獨(dú)立危險(xiǎn)因素為病理學(xué)分級和臨床分期。
[Abstract]:Objective: to investigate the natural survival rate of laryngeal carcinoma and its influencing factors. Methods: the clinical data of 188 patients with laryngeal cancer without laryngectomy or radiotherapy and chemotherapy from January 1, 2000 to December 31, 2007 were retrospectively analyzed, including age, history of smoking, family history of cancer, history of tuberculosis, location of tumor growth. Pathological grading T staging N staging, clinical staging and history of tracheotomy. The survival rate was calculated by Kaplan-Meier multiplication limit method. The comparison between univariate analysis groups was performed with Log-rank test and multivariate analysis with Cox proportional risk model. Results: the overall median survival time was 14 鹵1.47 months, 1 year, 2 years and 5 years survival rate was 54.7 and 26.60.Not one case (except those who lost the interview) had survived more than 5 years. The median survival time was 33 鹵5.72 months and 2 / 1 respectively. The annual survival rate was 75.1% and 57.9%, and the median survival time of stage 鈪，

本文編號：2012912