本文選題：年齡相關(guān)性黃斑變性 + 外層視網(wǎng)膜管狀結(jié)構(gòu)　； 參考：《眼科新進(jìn)展》2014年10期

【摘要】：目的觀察濕性年齡相關(guān)性黃斑變性(age-related macular degeneration,AMD)患者的黃斑部外層視網(wǎng)膜管狀結(jié)構(gòu)(outer retinal tubulation,ORT)的OCT特征并分析其臨床意義。方法回顧性分析經(jīng)臨床確診的390例(478眼)濕性AMD患者的黃斑部OCT圖像,對(duì)ORT的發(fā)生率、形態(tài)、大小、數(shù)量、位置及經(jīng)抗血管內(nèi)皮生長(zhǎng)因子治療后的形態(tài)變化進(jìn)行分析總結(jié)。結(jié)果 478眼中有38眼黃斑部存在ORT,ORT發(fā)生率為7.95%;ORT主要存在于外層視網(wǎng)膜,表現(xiàn)為圓形或橢圓形高反射環(huán),其內(nèi)呈低反射或點(diǎn)狀高反射;ORT的長(zhǎng)度為73~3230μm,高度為73~183μm,每張OCT圖像可見1~4個(gè)ORT。38眼中15眼曾接受玻璃體內(nèi)注射抗血管內(nèi)皮生長(zhǎng)因子藥物治療,治療后2~4個(gè)月黃斑部視網(wǎng)膜水腫減輕或消失,大多數(shù)患者ORT大小、位置無(wú)明顯變化,僅1眼ORT內(nèi)高反射物質(zhì)較治療前減少。結(jié)論部分濕性AMD患者黃斑部可見ORT,這些結(jié)構(gòu)不同于視網(wǎng)膜囊樣水腫,抗新生血管藥物治療后結(jié)構(gòu)變化不明顯或無(wú)變化。
[Abstract]:Objective to observe the OCT features and clinical significance of outer retinal tubuloid structure (ORT) of outer retina of macular region in patients with age-related macular degenerationin wet age-related macular degeneration. Methods the macular OCT images of 390 cases (478 eyes) with AMD were analyzed retrospectively. The incidence, shape, size, quantity, location and morphological changes of ORT after treatment with antivascular endothelial growth factor were analyzed and summarized. Results in 478 eyes, the incidence of ORT in macular region was 7.95. ORT was mainly present in the outer retina, with the appearance of circular or elliptical high reflex ring. The length and height of low reflex or dot high reflex ORT were 73 ~ 3230 渭 m and 73 ~ 183 渭 m respectively. 15 eyes of 1 ~ 4 ORT.38 eyes were treated with intravitreous injection of antivascular endothelial growth factor (VEGF). The macular retinal edema was alleviated or disappeared 2 ~ 4 months after treatment. The size and location of ORT in most of the patients did not change obviously. Only one eye had less hyperreflex substance in ORT than before treatment. Conclusion ORT was found in macular region of partial wet AMD patients. These structures were different from retinal sac edema, and the changes of antiangiogenic drugs were not obvious or no change.
【作者單位】： 山東省醫(yī)學(xué)科學(xué)院山東省眼科研究所青島眼科醫(yī)院;
【基金】：山東省醫(yī)藥衛(wèi)生科技發(fā)展計(jì)劃保健項(xiàng)目(編號(hào):2013BJYB27)~~
【分類號(hào)】：R774.5

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本文編號(hào)：1977117