本文選題：核磁共振 + 擴散加權(quán)成像　； 參考：《廣西醫(yī)科大學》2011年碩士論文

【摘要】：目的探討磁共振加權(quán)成像及ADC值對鼻咽癌的診斷價值。 材料與方法研究對象為廣西醫(yī)科大學第一附屬醫(yī)院2010年5月至2011年1月初診且經(jīng)纖維鼻咽鏡活檢確診鼻咽癌患者53例均行常規(guī)MR及增強掃描,單次激發(fā)自旋回波平面回波擴散加權(quán)成像,b值取1000s/mm~2,正常組行常規(guī)MR及DWI掃描;測量患者鼻咽癌原發(fā)灶、鼻咽癌轉(zhuǎn)移淋巴結(jié)與正常人淋巴結(jié)的表觀擴散系數(shù)(ADC)值;使用SPSS13.0統(tǒng)計學軟件包對數(shù)據(jù)進行方差分析和配對t檢驗,P0.05為差異有統(tǒng)計學意義。 結(jié)果DWI圖對腫塊型鼻咽癌顯示清晰,但對黏膜型鼻咽癌顯示不佳,對轉(zhuǎn)移淋巴結(jié)檢出率為100%。鼻咽癌、轉(zhuǎn)移淋巴結(jié)和正常淋巴結(jié)ADC值分別為0.799±0.157×10~(-3)mm~2/s、0.850±0.128×10~(-3)mm~2/s、1.039±0.165×10~(-3)mm~2/s。鼻咽癌與轉(zhuǎn)移淋巴結(jié)的平均ADC值差異無統(tǒng)計學意義,鼻咽癌及轉(zhuǎn)移淋巴結(jié)平均ADC值與正常淋巴結(jié)平均ADC值差異有統(tǒng)計學意義且兩者平均ADC值均低于正常淋巴結(jié)平均ADC值。當b=1000s/mm~2,ADC閾值取0.844×10~(-3)mm~2/s時,鑒別鼻咽癌與正常淋巴結(jié)的敏感性為94.6%,特異性為72.5%;當ADC閾值取0.840×10~(-3)mm~2/s時,鑒別轉(zhuǎn)移淋巴結(jié)與正常淋巴結(jié)的敏感性為97.3%,特異性為75%。 結(jié)論磁共振擴散加權(quán)成像及ADC值的測量對鼻咽癌及其轉(zhuǎn)移淋巴結(jié)有一定的診斷價值。
[Abstract]:Objective to evaluate the diagnostic value of magnetic resonance weighted imaging (MRI) and ADC value in nasopharyngeal carcinoma (NPC). Materials and methods from May 2010 to January 2011, 53 patients with nasopharyngeal carcinoma (NPC) confirmed by fiberoptic nasopharyngoscope biopsy in the first affiliated Hospital of Guangxi Medical University underwent conventional and enhanced Mr scans. Single excitation spin echo plane echo diffusion weighted imaging was performed at 1000s / mm ~ (-2), and normal group was performed conventional Mr and DWI scans, and the apparent diffusion coefficient (ADCC) of metastatic lymph nodes of nasopharyngeal carcinoma (NPC), metastatic lymph nodes of nasopharyngeal carcinoma (NPC) and normal lymph nodes were measured. SPSS13.0 statistical software package was used to analyze the variance of data and paired t test (P0.05). Results DWI showed clearly in lumped nasopharyngeal carcinoma, but not in mucosal nasopharyngeal carcinoma. The detection rate of metastatic lymph node was 100%. The ADC values of nasopharyngeal carcinoma, metastatic lymph nodes and normal lymph nodes were 0.799 鹵0.157 脳 10 ~ (-3) mm ~ (-1) and 0.850 鹵0.128 脳 10 ~ (10) ~ (-3) mm ~ (-1) / s respectively. There was no significant difference in mean ADC value between nasopharyngeal carcinoma and metastatic lymph nodes. The mean ADC value of nasopharyngeal carcinoma and metastatic lymph nodes was significantly different from that of normal lymph nodes, and the average ADC value of NPC and metastatic lymph nodes was lower than the average ADC value of normal lymph nodes. The sensitivity and specificity of differentiating nasopharyngeal carcinoma from normal lymph nodes were 94.6 and 72.5 respectively when the threshold value of BX 1000s / mm2ADC was 0.844 脳 10~(-3)mm~2/s, and when the threshold value of ADC was 0.840 脳 10~(-3)mm~2/s, the sensitivity and specificity of differentiating metastatic lymph nodes from normal lymph nodes were 97.3and 75.75 脳 10~(-3)mm~2/s respectively. Conclusion Diffusion-weighted Mr imaging and ADC measurement are valuable in the diagnosis of nasopharyngeal carcinoma and its metastatic lymph nodes.
【學位授予單位】：廣西醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2011
【分類號】：R445.2;R739.63

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本文編號：1960476