本文選題：蛋白Slit2 + 喉咽腫瘤��； 參考：《山東大學(xué)》2010年碩士論文

【摘要】：目的：研究喉咽鱗狀細(xì)胞癌組織中神經(jīng)遷移蛋白Slit2的表達(dá)及其與淋巴管密度的關(guān)系,探討兩者對(duì)該腫瘤生物學(xué)行為的影響。 方法：用免疫組織化學(xué)法檢測(cè)Slit2蛋白及淋巴管密度(LVD)的表達(dá),分析其與喉咽鱗癌病理分型、臨床分級(jí)及預(yù)后的關(guān)系。 結(jié)果：Slit2蛋白在喉咽鱗狀細(xì)胞癌和癌旁組織中的表達(dá)率分別為65.2%和40.5%,兩者表達(dá)差異有統(tǒng)計(jì)學(xué)意義(χ2=6.329,P0.05)；Slit2蛋白的表達(dá)與腫瘤大小、TNM分期、淋巴結(jié)轉(zhuǎn)移顯著相關(guān)；LVD計(jì)數(shù)與腫瘤大小、病理類型、浸潤(rùn)深度、TNM分期和淋巴結(jié)轉(zhuǎn)移顯著相關(guān),兩者與腫瘤的發(fā)病年齡、部位等均無明顯相關(guān)。Slit2陽(yáng)性表達(dá)的腫瘤組織中,周邊LVD計(jì)數(shù)高于Slit2陰性表達(dá)者,其差異具有統(tǒng)計(jì)學(xué)意義(t=2.273,P0.05)；并且兩者表達(dá)呈正相關(guān)(rs=0.430,P0.05) 結(jié)論：喉咽鱗狀細(xì)胞癌組織中Slit2表達(dá)和LVD計(jì)數(shù),與腫瘤的侵襲和淋巴結(jié)轉(zhuǎn)移密切相關(guān),其機(jī)制可能為Slit2信號(hào)系統(tǒng)介導(dǎo)了腫瘤微小淋巴管的形成,從而影響了腫瘤的生物學(xué)行為。
[Abstract]:Aim: to study the expression of neuromigration protein (Slit2) and its relationship with lymphatic density in larynx squamous cell carcinoma (LSCC), and to explore the effects of the two on the biological behavior of larynx squamous cell carcinoma (LSCC). Methods: immunohistochemical method was used to detect the expression of Slit2 protein and lymphatic density in larynx squamous cell carcinoma (LSCC). Results the expression rates of Slit2 protein were 65.2% and 40.5% in larynx squamous cell carcinoma and paracancerous tissues, respectively. There was a significant difference between the expression of Slit2 protein and TNM stage of tumor size, lymph node metastasis and tumor size. The pathological type, depth of invasion, TNM staging and lymph node metastasis were significantly correlated with the age and location of tumor onset, and the peripheral LVD count was higher than that of negative expression of Slit2 in the tumor tissues with positive expression of Slit2. The difference was statistically significant (P 0.05), and the positive correlation was found between the two expression levels. Conclusion: the expression of Slit2 and LVD count in laryngeal squamous cell carcinoma are closely related to tumor invasion and lymph node metastasis. The mechanism may be that Slit2 signaling system mediates the formation of small lymphatic vessels in the tumor and thus affects the biological behavior of the tumor.
【學(xué)位授予單位】：山東大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2010
【分類號(hào)】：R739.6

【參考文獻(xiàn)】

相關(guān)期刊論文 前1條

1 姚磊;張中華;馬超;雷大鵬;潘新良;;下咽鱗狀細(xì)胞癌中Slit2的表達(dá)及其與微血管密度關(guān)系的臨床研究[J];山東大學(xué)耳鼻喉眼學(xué)報(bào);2009年01期

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本文編號(hào)：1952656