本文選題：鼻咽癌 + 調強��； 參考：《瀘州醫(yī)學院》2011年碩士論文

【摘要】：目的：放射治療是鼻咽癌首選的治療手段。在惡性腫瘤的放射治療中,原發(fā)腫瘤容積作為預后因素之一,正越來越受到臨床醫(yī)生的關注。本研究通過對鼻咽癌患者原發(fā)腫瘤容積的研究,初步探討鼻咽癌患者的原發(fā)腫瘤容積與臨床不同治療模式的關系及其預后的意義,為更加合理的治療鼻咽癌提供臨床依據。 材料和方法：本研究對接受新輔助化療加同期放化療(CCRT)或同期放化療的鼻咽癌患者進行了一項回顧性分析研究,以研究鼻咽癌原發(fā)灶大小對治療結果的影響,回顧性分析了68例接受調強放射治療的晚期鼻咽癌患者(Ⅲ-Ⅳ期)的資料,所有患者鼻咽病理均為低分化鱗癌.原發(fā)灶根據鼻咽癌2002 UICC分期,T2-T4期患者數分別為14、27和27例。接受新輔助化療加同期放化療放療患者為20例(占29.4%),接受同期放化療患者為48(占70.6%),鼻咽部病灶照射劑量為69-75Gy,30-33分次,6-7周。放療前的CT/MRI融合圖像在NOMOS公司CORVUS逆向計劃系統(tǒng)直接逐層勾畫腫瘤邊緣在相應CT圖像中,利用放療計劃系統(tǒng)自動計算出比較精確的腫瘤容積,原發(fā)灶的區(qū)域GTV包括原發(fā)腫瘤和咽后侵犯的淋巴結。結果：全組患者的原發(fā)腫瘤容積大小,其范圍為(11.94-108.00)cm3,中位數為57.63cm3,平均數為60.83cm3。將50cm3作為全組患者原發(fā)腫瘤容積的臨界點,將其分
[Abstract]:Objective: radiotherapy is the first choice for nasopharyngeal carcinoma. Primary tumor volume, as a prognostic factor, has attracted more and more attention of clinicians in radiotherapy of malignant tumors. Through the study of primary tumor volume in patients with nasopharyngeal carcinoma (NPC), the relationship between primary tumor volume and different clinical treatment modes and its prognostic significance were preliminarily discussed in order to provide a more reasonable clinical basis for the treatment of nasopharyngeal carcinoma (NPC). Materials and methods: a retrospective study was conducted in patients with nasopharyngeal carcinoma (NPC) receiving neoadjuvant chemotherapy plus concurrent radiotherapy and chemotherapy (CCRTT) or concurrent radiotherapy and chemotherapy to study the effect of primary tumor size on the outcome of treatment. The data of 68 patients with advanced nasopharyngeal carcinoma (stage 鈪，

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