本文選題：光學(xué)相干斷層掃描 + 視網(wǎng)膜中央動(dòng)脈阻塞　； 參考：《石河子大學(xué)》2014年碩士論文

【摘要】：目的：探討光學(xué)相干斷層掃描在視網(wǎng)膜動(dòng)脈阻塞疾病中的應(yīng)用并分析內(nèi)層視網(wǎng)膜厚度與患者治療前后視力是否存在相關(guān)性。 方法：收集2010年7月至2013年11月在石河子大學(xué)醫(yī)學(xué)院第一附屬醫(yī)院住院的視網(wǎng)膜動(dòng)脈阻塞患者27例（27只眼），其中男性患者16例，女性患者11例；年齡37歲-83歲（平均60.65歲）；右眼17例，左眼10例。其中診斷為視網(wǎng)膜中央動(dòng)脈阻塞患者共15例（15只眼）；診斷為視網(wǎng)膜分支動(dòng)脈阻塞患者共12例（12只眼）。收集患者發(fā)病至入院時(shí)間、初始視力、治療后視力，采用TOPCON3D OCT-1000對(duì)患者進(jìn)行黃斑OCT檢查，測(cè)量黃斑區(qū)視網(wǎng)膜厚度，進(jìn)行定量測(cè)定和分析黃斑中心凹、距中心小凹3mm及6mm上、下、鼻、顳側(cè)扇形面積下視網(wǎng)膜全層的平均厚度。內(nèi)層視網(wǎng)膜厚度采用人工手動(dòng)測(cè)量。距黃斑中心小凹1mm處內(nèi)層視網(wǎng)膜，鼻側(cè)記為N1，顳側(cè)記為T1，距黃斑中心小凹3mm處內(nèi)層視網(wǎng)膜，鼻側(cè)記為N3，顳側(cè)記為T3。并進(jìn)行統(tǒng)計(jì)分析，各組數(shù)據(jù)均用均數(shù)標(biāo)準(zhǔn)差(s)表示。所得實(shí)驗(yàn)數(shù)據(jù)兩組均數(shù)的比較采用t檢驗(yàn)，等級(jí)資料相關(guān)性采用Spearman相關(guān)分析，P0.05認(rèn)為差異有統(tǒng)計(jì)學(xué)意義。 結(jié)果：19/27的患者視力均有不同程度的提高。經(jīng)過治療后視網(wǎng)膜中央動(dòng)脈阻塞患者的視力與初始視力相比，差異有統(tǒng)計(jì)學(xué)意義（P=0.0350.05）。年齡、患全身疾病情況對(duì)患者最終視力無明顯影響，（P=0.0910.05）。患視網(wǎng)膜中央動(dòng)脈阻塞眼的黃斑中心凹及鼻側(cè)3mm扇形面積下視網(wǎng)膜全層厚度比對(duì)側(cè)健眼增厚（P 0.05），余各區(qū)域面積下視網(wǎng)膜全層厚度與健眼相比無統(tǒng)計(jì)學(xué)差異（P0.05）；患眼N1、N3及T3均比健眼增厚（P 0.05）；黃斑中心凹厚度患眼與健眼的差值與治療后視力呈負(fù)相關(guān)，，r=-0.740（P 0.05）；患眼與健眼N1、T3的差值與治療后視力呈負(fù)相關(guān)，r(N1)=-0.692, r(T3)=-0.657（P0.05）。視網(wǎng)膜分支動(dòng)脈阻塞各組數(shù)據(jù)比較及相關(guān)性分析，結(jié)果均無統(tǒng)計(jì)學(xué)意義。 結(jié)論：OCT測(cè)量視網(wǎng)膜中央動(dòng)脈阻塞患者黃斑中心凹厚度及內(nèi)層視網(wǎng)膜厚度，發(fā)現(xiàn)黃斑區(qū)視網(wǎng)膜水腫程度與疾病預(yù)后視力之間呈負(fù)相關(guān)。OCT檢查對(duì)視網(wǎng)膜中央動(dòng)脈阻塞患者預(yù)測(cè)治療后的視力有一定的作用。
[Abstract]:Objective: to investigate the application of optical coherence tomography (OCT) in the diagnosis of retinal artery occlusion and to analyze the correlation between the thickness of the inner retina and the visual acuity of the patients before and after treatment. Methods: from July 2010 to November 2013, 27 patients with retinal artery occlusion were collected from the first affiliated Hospital of Shihezi University Medical College, including 16 male and 11 female. The age ranged from 37 to 83 years (mean 60.65 years), right eye 17 cases, left eye 10 cases. 15 eyes were diagnosed as central retinal artery occlusion and 12 eyes were diagnosed as retinal branch artery occlusion. The time from onset to admission, initial visual acuity and visual acuity after treatment were collected. Macular OCT was performed with TOPCON3D OCT-1000, retinal thickness in macular area was measured, and macular fovea was quantitatively measured and analyzed. The distance between 3mm and 6mm was analyzed. The average thickness of the whole layer of the retina under the nasal and temporal fan-shaped area. The thickness of the inner retina was measured manually. The inner retina of 1mm from central fovea of macular, nasal side is N 1, temporal side is T 1, internal layer retina of 3mm from central fovea of macula, nasal side is N 3, temporal side is T 3. Statistical analysis was carried out, and the data of each group were expressed by mean standard deviation (s). T test was used to compare the mean of the two groups of experimental data, and the correlation of grade data was analyzed by Spearman correlation analysis (P0.05). The results showed that percent of the 19 / 27 patients improved their eyesight to varying degrees. After treatment, the visual acuity of the patients with central retinal artery occlusion was significantly different from that of the initial visual acuity. Age, systemic disease had no significant effect on the final visual acuity of the patients. The thickness of the whole retinal layer in the macular fovea and nasal 3mm fan area in the eyes with central retinal artery occlusion was higher than that in the normal eyes (P 0.05), but there was no significant difference in the thickness of the whole retinal layer between the other areas and the normal eyes (P 0.05). The difference between the thickness of macular fovea and normal eyes was negatively correlated with the visual acuity after treatment, and the difference between N1T 3 and N1T 3 was negatively correlated with the visual acuity after treatment, and there was a negative correlation between the difference of T 3 and the visual acuity after treatment, and the difference between the thickness of macular fovea and that of normal eyes was negatively correlated with the visual acuity after treatment. There was no significant difference between the data of each group and the correlation analysis. Conclusion the macular fovea thickness and inner retinal thickness in patients with central retinal artery occlusion were measured by Oct. It was found that the degree of retinal edema in macular area was negatively correlated with the prognosis of the disease. Oct had a certain role in predicting the visual acuity after treatment in patients with central retinal artery occlusion.
【學(xué)位授予單位】：石河子大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R774.1

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 趙婕;孫曉東;陸豪;嚴(yán)良;秦潔;;病理性近視黃斑出血的眼底特征及光學(xué)相干斷層掃描分析[J];國際眼科雜志;2010年09期

2 張艷明;張衛(wèi)紅;;高度近視黃斑區(qū)視網(wǎng)膜厚度變化規(guī)律的分析[J];國際眼科雜志;2013年05期

3 傅東紅,胡甸萍,浦麗娟,史惠琴;視覺誘發(fā)電位和視網(wǎng)膜電圖對(duì)高度近視眼視功能的評(píng)估[J];中國臨床康復(fù);2004年25期

4 余敏忠;斜視性弱視眼的多焦視誘發(fā)電位特征[J];眼科新進(jìn)展;2001年04期

5 郭麗;吳航;吉訓(xùn)明;方薇;;超選擇眼動(dòng)脈溶栓介入治療視網(wǎng)膜中央動(dòng)脈阻塞[J];眼科;2007年04期

6 胡恩海;劉慶淮;;曲安奈德不同給藥方式治療黃斑水腫的臨床療效觀察[J];中國眼耳鼻喉科雜志;2011年02期

7 李梅,凌運(yùn)蘭,劉杏,馮官光,易長賢,鄭小平;視網(wǎng)膜中央動(dòng)脈阻塞性缺血對(duì)黃斑區(qū)視網(wǎng)膜神經(jīng)上皮的影響[J];中國病理生理雜志;2001年08期

8 鄧金印，高汝龍，酈全福，吳德正，楊邦蘭，林延德;52例糖尿病患者圖形視誘發(fā)電位檢測(cè)[J];中華眼底病雜志;1995年03期

9 雷嘉啟,楊鈞;視網(wǎng)膜中央動(dòng)脈阻塞患者視力恢復(fù)的分析[J];中華眼底病雜志;1996年04期

10 侯憲如;;筋膜下膠原海綿灌注系統(tǒng)治療視網(wǎng)膜動(dòng)脈阻塞[J];中國實(shí)用眼科雜志;2006年08期

本文編號(hào)：1863956