本文選題：鼻咽癌 + 放療��； 參考：《中南大學(xué)》2011年碩士論文

【摘要】：目的： 探討鼻咽癌患者放療后齲活性變化。定量分析鼻咽癌患者放療前后唾液中的鈣、磷含量及其變化,并以健康志愿者為對照,探討放療對鼻咽癌患者唾液中鈣、磷含量的影響,為放射齲的預(yù)防和病因研究提供理論依據(jù)。 方法： 鼻咽癌患者28例和健康志愿者20例。刃天青紙片法檢測鼻咽癌患者放療前、放療70Gy后的齲活性,火焰原子吸收光譜法和鉬銻抗分光光度法測定鼻咽癌患者放療前、放療70Gy后及健康志愿者非刺激性唾液中的鈣、磷含量。 結(jié)果： ①刃天青紙片法顯示鼻咽癌患者放療70Gy后齲活性增加(P0.01)。 ②鼻咽癌患者放療前唾液中鈣含量為63.19mg/l,放療70Gy后唾液中鈣含量為33.38mg/l。經(jīng)統(tǒng)計(jì)分析,放療前、放療70Gy后唾液中鈣含量的差異有統(tǒng)計(jì)學(xué)意義(P0.01)。鼻咽癌患者放療前唾液中磷含量為132.96mg/l,放療70Gy后唾液中磷含量為49.18mg/l,經(jīng)統(tǒng)計(jì)分析,放療前、放療70Gy后唾液中磷含量的差異有統(tǒng)計(jì)學(xué)意義(P0.01)。男性、女性鼻咽癌患者放療前、放療70Gy后唾液中鈣、磷含量的差異無統(tǒng)計(jì)學(xué)意義(P0.05)。男性、女性鼻咽癌患者放療前、放療70Gy后唾液中鈣、磷含量差值的差異無統(tǒng)計(jì)學(xué)意義(P0.05)。Ⅲ期、Ⅳa期鼻咽癌患者放療前、放療70Gy后唾液中鈣、磷含量的差異無統(tǒng)計(jì)學(xué)意義(P0.05)。Ⅲ期、Ⅳa期鼻咽癌患者放療前、放療70Gy后唾液中鈣、磷含量差值的差異無統(tǒng)計(jì)學(xué)意義(P0.05)。 結(jié)論： ①放療70Gy后鼻咽癌患者的齲活性增加。 ②放療70Gy后唾液中鈣、磷含量減少。鼻咽癌患者放療前、放療70Gy后唾液中鈣、磷含量的變化與性別和臨床分期無明顯關(guān)系。
[Abstract]:Objective: To investigate the changes of caries activity in patients with nasopharyngeal carcinoma after radiotherapy. The contents and changes of calcium and phosphorus in saliva of patients with nasopharyngeal carcinoma before and after radiotherapy were analyzed quantitatively, and the effects of radiotherapy on the contents of calcium and phosphorus in saliva of patients with nasopharyngeal carcinoma were studied with healthy volunteers as control. To provide theoretical basis for the prevention and etiology of radiation caries. Methods: There were 28 patients with nasopharyngeal carcinoma and 20 healthy volunteers. The caries activity of nasopharyngeal carcinoma (NPC) patients before and after radiotherapy (70Gy) was detected by edge azure disk method. The calcium in nonirritated saliva was measured by flame atomic absorption spectrometry (FAS) and molybdenum antimony antimony antimony spectrophotometry (MASS) before radiotherapy, after radiotherapy (70Gy) and in healthy volunteers. Phosphorus content Results: One edge azure disk method showed that the caries activity of nasopharyngeal carcinoma patients increased after 70Gy irradiation (P 0.01). 2the calcium content in saliva of NPC patients was 63.19 mg / l before radiotherapy and 33.38 mg / L after radiotherapy with 70Gy. After statistical analysis, the difference of saliva calcium content before and after 70Gy was statistically significant (P 0.01). The phosphorus content in saliva of NPC patients was 132.96 mg / l before radiotherapy and 49.18 mg / L after radiotherapy with 70Gy. Statistical analysis showed that there was significant difference in phosphorus content in saliva before radiotherapy and after 70Gy. There was no significant difference in calcium and phosphorus contents in saliva between male and female patients with nasopharyngeal carcinoma (NPC) before radiotherapy and after radiotherapy with 70Gy (P 0.05). There was no significant difference in the contents of calcium and phosphorus in saliva between male and female patients with nasopharyngeal carcinoma before radiotherapy and after 70Gy. There was no significant difference in the contents of calcium in saliva of patients with stage 鈪，

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