本文選題：視神經(jīng)炎 + 復(fù)方樟柳堿��； 參考：《廣西醫(yī)科大學(xué)》2014年碩士論文

【摘要】：目的:探討大劑量甲基強(qiáng)的松龍聯(lián)合復(fù)方樟柳堿治療視神經(jīng)炎的臨床療效 方法:對廣西醫(yī)科大學(xué)一附院眼科2012年1月至2013年12月收治的急性視神經(jīng)炎患者的病案資料進(jìn)行回顧性分析。臨床確診為視神經(jīng)炎的51例患者69眼納入研究，其中，視神經(jīng)乳頭炎16例，球后視神經(jīng)炎35例，將患者分為治療組和對照組，分別為25例34只眼和26例35只眼，治療組給予維生素B1，B1210mg口服,3次/日,甲基強(qiáng)的松龍500mg溶于500ml5%葡萄糖氯化鈉溶液中靜脈滴注，每日一次，連用6日后，減為240mg/d，連用3天后改醋酸潑尼松龍片60mg晨起頓服，每周減2片，減至30mg時小劑量遞減維持，同時注意補(bǔ)鉀護(hù)胃補(bǔ)鈣。并以復(fù)方樟柳堿注射液2ml患側(cè)顳淺動脈旁皮下注射，每日一次，對照組除不用復(fù)方樟柳堿注射液外，其余處理與治療組相同。對比分析兩組治療后的療效差異。 結(jié)果:治療組治愈15眼，顯效14眼，有效4眼，無效1眼，總有效率97%；對照組治愈10眼，顯效11眼，有效10眼，無效4眼，總有效率88.5%。兩組的總有效率比較有統(tǒng)計學(xué)意義（P0.05) 結(jié)論:復(fù)方樟柳堿顳淺動脈旁皮下注射治療早期視神經(jīng)炎，可有效改善視神經(jīng)及附近的血液循環(huán)，改善血供，促進(jìn)組織缺血,缺氧在短時間內(nèi)得到恢復(fù)，從而改善患者視力。且臨床運(yùn)用安全有效，，價格低廉，值得推廣。
[Abstract]:Objective: to investigate the clinical effect of high-dose methylprednisolone combined with compound anisodine in the treatment of optic neuritis.Methods: the medical records of patients with acute optic neuritis admitted from January 2012 to December 2013 in the affiliated Hospital of Guangxi Medical University were retrospectively analyzed.Sixty-nine eyes of 51 patients with optic neuritis were included in the study. Among them, there were 16 cases of optic papilltis and 35 cases of retrobulbar optic neuritis. The patients were divided into treatment group and control group, 25 cases, 34 eyes and 26 cases, 35 eyes, respectively.In the treatment group, vitamin B1 B1210mg was given orally three times a day. Methylprednisolone 500mg was given intravenously in 500ml 5% glucose sodium chloride solution, once a day for 6 days, reduced to 240 mg / d. After 3 days of treatment, prednisolone acetate tablet 60mg was taken in the morning.Decrease 2 tablets a week, reduce to 30mg, small dose decrease and maintain, at the same time, pay attention to potassium to protect stomach to supplement calcium.Compound anisodine injection (2ml) was injected subcutaneously to the superficial temporal artery of the affected side once a day. The control group was treated the same as the treatment group except for the compound anisodine injection.The difference of curative effect between the two groups after treatment was compared and analyzed.Results: in the treatment group, 15 eyes were cured, 14 eyes were effective, 4 eyes were effective, 1 eye was ineffective, the total effective rate was 97%, while in the control group, 10 eyes were cured, 11 eyes were markedly effective, 10 eyes were effective, 4 eyes were ineffective, and the total effective rate was 88.5.The total effective rate of the two groups was significantly higher than that of the control group (P0.05).Conclusion: the treatment of early optic neuritis by subcutaneous injection of compound anisodine along the superficial temporal artery can effectively improve the blood circulation of the optic nerve and its vicinity, improve blood supply, promote tissue ischemia, and restore anoxia in a short time, thus improving the visual acuity of the patients.And the clinical application is safe and effective, the price is low, it is worth popularizing.
【學(xué)位授予單位】：廣西醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R774.61

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