本文選題：視覺顯著性 + 感受野��； 參考：《天津醫(yī)科大學(xué)》2010年碩士論文

【摘要】：研究目的：研究感受野外不同顯著性視覺刺激對貓初級視皮層神經(jīng)元反應(yīng)影響。 研究方法：利用細胞外記錄技術(shù),記錄麻醉狀態(tài)下成年貓初級視皮層神經(jīng)元在感受野內(nèi)或伴有感受野外2。外不同的刺激組合模式下的反應(yīng)。對不同刺激模式下的記錄結(jié)果繪制神經(jīng)元反應(yīng)的刺激后時間直方圖(Post-stimulus time-histograms, PSTH),從中提取出發(fā)放率、反應(yīng)潛時和變異度等指標,用不同刺激模式下的發(fā)放率除以僅有感受野內(nèi)刺激時發(fā)放率計算標準化反應(yīng),運用SPSS13.0對上述指標進行統(tǒng)計學(xué)分析。 結(jié)果：1.感受野確定與面積整合曲線：給予感受野位置面積不斷增大的圓形光柵刺激,刺激直徑由2°開始遞增至30°,根據(jù)其發(fā)放率隨面積增大達到的第一個峰值從而得出經(jīng)典感受野(classical receptive field, CRF)的面積。細胞發(fā)放率在刺激超出CRF后下降,根據(jù)其有無發(fā)放率再次增加分為抑制型和去抑制型。面積整合對時間特性的影響表現(xiàn)為當刺激面積增大至超出感受野后潛時變短,變異度變小(p0.05)。 2.感受野外視覺刺激對比度對神經(jīng)元反應(yīng)的調(diào)制作用：給予感受野內(nèi)100%對比度最優(yōu)調(diào)制特征的刺激以及伴有感受野2。外不同對比度(100%、70%、50%、30%和10%)刺激。根據(jù)伴有對比度100%感受野外刺激的標準化反應(yīng)是否大于1,分為易化或抑制反應(yīng)：易化反應(yīng)隨感受野外對比度改變符合quadratic模型：y=1.160+1.911x-1.554x2(其中y為標準化反應(yīng),x為感受野外對比度),p=0.026；抑制性反應(yīng)隨感受野外對比度降低,其抑制作用減弱,表現(xiàn)為標準化反應(yīng)數(shù)值的增加,其反應(yīng)潛時不符合任何模型。 3、感受野外視覺刺激方向?qū)ι窠?jīng)元反應(yīng)的調(diào)制作用：當感受野外刺激光柵方向與感受野內(nèi)光柵方向垂直時,在抑制反應(yīng)表現(xiàn)為抑制作用減弱,表現(xiàn)為55%細胞翻轉(zhuǎn)為易化反應(yīng)；易化反應(yīng)表現(xiàn)為表現(xiàn)為易化作用減弱,與上述quadratic模型曲線對比度為5%標準化反應(yīng)對應(yīng)。 4、感受野外視覺刺激拓撲形狀對神經(jīng)元反應(yīng)的調(diào)制作用：當感受野外環(huán)形和C型拓撲形狀刺激,在抑制性反應(yīng)表現(xiàn)為抑制性作用減弱,易化性反應(yīng)表現(xiàn)為易化作用減弱,分別與模型曲線對比度15%和15%對應(yīng)。 5、感受野內(nèi)對比度改變情況下感受野外視覺刺激對神經(jīng)元反應(yīng)調(diào)制作用：給予感受野內(nèi)不同對比度視覺刺激(70%、50%、30%、10%)刺激伴有感受野外相同對比度或100%對比度視覺刺激。易化性反應(yīng)和抑制性反應(yīng)表現(xiàn)為感受野外100%對比度視覺刺激對神經(jīng)元的作用大于與感受野具有相同對比度的視覺刺激對神經(jīng)元反應(yīng)的作用,除易化性反應(yīng)于感受野內(nèi)刺激對比度在10%狀況下。 6、間隙作用：感受野外伴隨刺激與感受野內(nèi)刺激之間有間隙存在時,感受野外刺激對神經(jīng)元的影響為：發(fā)放率增加(p0.05)。 結(jié)論：感受野外視覺刺激顯著性對視皮層初級神經(jīng)元發(fā)放率的調(diào)制作用,隨其視覺顯著性增大,對神經(jīng)元的調(diào)制作用增大。視覺刺激顯著性相對強度可以通過感受野外視覺刺激顯著性對視皮層初級神經(jīng)元發(fā)放率的調(diào)制作用進行定量。間隙效應(yīng)是感受野外伴隨刺激對神經(jīng)元的調(diào)制的一個重要的影響因素。
[Abstract]:Objective : To study the effects of different visual stimuli on cortical neurons in the primary visual cortex of cats .

Methods : Using extracellular recording technique , the responses of primary visual cortex neurons of adult cat were recorded in the receptive field or in the external stimuli combined mode . The post - stimulus time - histogram ( PSTH ) was used to calculate the post - stimulus time - histogram ( PSTH ) .

Results : 1 . receptive field determination and area integration curve : the circular grating stimulation with increasing area of receptive field was given , the stimulation diameter increased from 2 擄 to 30 擄 , and the area of classical receptive field ( CRF ) was obtained according to its release rate .

2 . The effects of field visual stimulation contrast on the response of neurons were observed : the stimulation of 100 % contrast optimal modulation feature in the receptive field and the external contrast ( 100 % , 70 % , 50 % , 30 % and 10 % ) were stimulated .
The inhibitory response decreased with the observed field contrast , and its inhibitory effect decreased , manifested as the increase of standardized reaction value , which did not accord with any model .

3 . The modulation effect of the field visual stimulation direction on the response of neurons was observed : when the direction of the field stimulation grating and the direction of the grating in the receptive field were felt , the inhibition reaction was weakened , and 55 % of the cells were turned to the facilitation reaction ;
The manifestation of the facilitation reaction was weakened , and the contrast ratio of the model curve was 5 % .

4 . The modulation effect of the topological shape of field visual stimulation on the response of neurons was observed : when the ring shape and the C - shaped topological form were felt , the inhibitory effect was weakened and the susceptibility reaction was weakened , and the contrast of the model curves was 15 % and 15 % respectively .

5 . The effect of field visual stimulation on neuron response was observed under the condition of contrast change in the receptive field : the visual stimuli with different contrast visual stimuli ( 70 % , 50 % , 30 % , 10 % ) in the receptive field were stimulated with the same contrast or 100 % contrast visual stimuli in the field .

6 . Gap effect : The effect of field stimulation on neurons was observed when there was a gap between the stimulation of the field and the stimulation of the receptive field : the release rate was increased ( p < 0.05 ) .

Conclusion : The effect of field visual stimulation on the modulation of primary neurons in the visual cortex increased with the increase of visual significance . The relative intensity of visual stimulus could be quantified by sensing the effect of field visual stimuli on the modulation of primary neurons in the visual cortex .

【學(xué)位授予單位】：天津醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2010
【分類號】：R77

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