本文選題：視網(wǎng)膜 + 神經(jīng)節(jié)細(xì)胞��； 參考：《上海交通大學(xué)》2011年碩士論文

【摘要】：視覺信號(hào)的初級(jí)處理發(fā)生在視網(wǎng)膜,視覺信號(hào)在視網(wǎng)膜光感受器細(xì)胞上形成輸入,并將其轉(zhuǎn)化為電信號(hào),經(jīng)視網(wǎng)膜神經(jīng)元回路傳遞至輸出神經(jīng)節(jié)細(xì)胞,形成動(dòng)作電位,再通過視神經(jīng)進(jìn)一步向視中樞傳遞。視網(wǎng)膜需要編碼的視覺信息通常比較復(fù)雜,同時(shí)在處理視覺信息時(shí)要受到視覺神經(jīng)通路的解剖結(jié)構(gòu)、以及神經(jīng)回路中各種噪聲的影響。在這些限制下,時(shí)空相關(guān)編碼模式被認(rèn)為是視網(wǎng)膜的一種高效處理視覺信息的方法。本文對(duì)多電極記錄到的特定光刺激下牛蛙視網(wǎng)膜神經(jīng)節(jié)細(xì)胞放電活動(dòng)進(jìn)行了研究,探討了時(shí)空相關(guān)編碼的特性。 主要結(jié)果包括兩部分:(1)基于信息熵理論,估算了神經(jīng)元放電序列的時(shí)間相關(guān)性指標(biāo);同時(shí)計(jì)算了神經(jīng)元活動(dòng)的空間相關(guān)性指標(biāo)。分析表明,對(duì)于單個(gè)神經(jīng)元而言,時(shí)間相關(guān)性指標(biāo)與空間相關(guān)性指標(biāo)是相互關(guān)聯(lián)的:時(shí)間相關(guān)性指標(biāo)大的神經(jīng)元,其空間相關(guān)性指標(biāo)也比較大。而且,進(jìn)一步研究發(fā)現(xiàn)簇狀放電(動(dòng)作電位間隔(inter-spike-interval,ISI)小于6 ms)在神經(jīng)元的時(shí)空相關(guān)放電模式中起著重要的作用:神經(jīng)元的簇狀放電越多,放電序列的時(shí)間相關(guān)性與空間相關(guān)性都越強(qiáng)。模型分析表明,時(shí)空相關(guān)性有助于更精確地預(yù)測(cè)神經(jīng)元的放電活動(dòng)。(2)分析了不同類型放電活動(dòng)的空間相關(guān)特性。將神經(jīng)元的放電活動(dòng)分為不同類型:類簇狀放電(動(dòng)作電位間隔小于等于30 ms),單次放電(動(dòng)作電位間隔大于30 ms)。分析發(fā)現(xiàn),類簇狀放電事件的空間相關(guān)性要強(qiáng)于單次放電事件的空間相關(guān)性,同時(shí)與其他神經(jīng)元形成相關(guān)活動(dòng)的類簇狀放電事件所編碼的感受野要小于與其他神經(jīng)元形成相關(guān)活動(dòng)的單次放電所編碼的感受野,這表明相關(guān)的類簇狀放電活動(dòng)編碼了更細(xì)節(jié)的空間信息。 從上述結(jié)果可以看出,時(shí)空相關(guān)模式有利于視網(wǎng)膜高效處理視覺信息,簇狀放電在調(diào)節(jié)視網(wǎng)膜時(shí)空反應(yīng)模式時(shí)起著重要的作用。
[Abstract]:The primary processing of visual signal takes place in the retina. The visual signal forms input on the photoreceptor cells of the retina and converts it into electrical signal, which is transmitted to the output ganglion cells through the retinal neuron circuit to form the action potential.Further transmission through the optic nerve to the optic center.The visual information which the retina needs to encode is usually complicated and is affected by the anatomical structure of the visual nerve pathway and various noises in the neural circuit.Under these constraints, spatiotemporal correlation coding pattern is considered to be an efficient method for processing visual information in retina.The discharge activity of retinal ganglion cells (RGCs) recorded by multiple electrodes under specific light stimulation in bullfrog was studied and the characteristics of space-time correlation coding were discussed.The main results include two parts: 1) based on the information entropy theory, the temporal correlation index of neuronal discharge sequence and the spatial correlation index of neuronal activity are estimated.The analysis shows that for a single neuron, the temporal correlation index is correlated with the spatial correlation index, and the spatial correlation index of the neuron with high temporal correlation index is also relatively large.Furthermore, it was found that the inter-spike-intervalis-ISI (action potential interval) plays an important role in the space-time related discharge pattern of neurons: the more clusters of neurons discharge,The temporal and spatial correlations of discharge sequences are stronger.The model analysis shows that the spatio-temporal correlation is helpful to predict the firing activity of neurons more accurately.) the spatial correlation characteristics of different types of firing activities are analyzed.The firing activities of neurons are divided into different types: cluster discharge (action potential interval less than or equal to 30 Ms) and single discharge (action potential interval greater than 30 Ms ~ (-1)).It is found that the spatial correlation of cluster-like discharge events is stronger than that of single discharge events.At the same time, the receptive fields encoded by the cluster-like discharge events associated with other neurons were less than those encoded by single discharges associated with other neurons.This indicates that the related cluster-like discharges encode more detailed spatial information.It can be seen from the above results that the spatio-temporal correlation pattern is beneficial to the efficient processing of visual information in the retina and that the cluster discharge plays an important role in regulating the temporal and spatial response of the retina.
【學(xué)位授予單位】：上海交通大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2011
【分類號(hào)】：R774

【共引文獻(xiàn)】

相關(guān)期刊論文 前3條

1 肖雷;景瑋;梁培基;;視網(wǎng)膜神經(jīng)節(jié)細(xì)胞的協(xié)同活動(dòng)以及信息編碼(英文)[J];生理學(xué)報(bào);2011年05期

2 龔含嫣;張溥明;;多通道神經(jīng)信號(hào)分析方法及其應(yīng)用(英文)[J];生理學(xué)報(bào);2011年05期

3 Hao Li;Pei-Ji Liang;;Stimulus discrimination via responses of retinal ganglion cells and dopamine-dependent modulation[J];Neuroscience Bulletin;2013年05期

相關(guān)博士學(xué)位論文 前1條

1 張瑩瑩;自然刺激下小雞視網(wǎng)膜神經(jīng)節(jié)細(xì)胞群體放電活動(dòng)時(shí)空特性的研究[D];上海交通大學(xué);2011年

相關(guān)碩士學(xué)位論文 前3條

1 李瑤;牛蛙視網(wǎng)膜神經(jīng)節(jié)細(xì)胞的感受野特性[D];上海交通大學(xué);2011年

2 談元鵬;基于壓縮感知理論的圖像識(shí)別與圖像流恢復(fù)方法研究[D];中國(guó)計(jì)量學(xué)院;2013年

3 劉俊敏;基于蛙眼視覺特性的運(yùn)動(dòng)目標(biāo)分析研究[D];湖南大學(xué);2013年

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本文編號(hào)：1749933