本文選題：三乙醇胺乳膏 + 鼻咽癌��； 參考：《廣西醫(yī)科大學(xué)》2010年碩士論文

【摘要】： 背景和目的:急性放射性口腔粘膜炎是鼻咽癌(NPC)放射治療過程中最常見的副反應(yīng)。本研究旨在探討鼻咽癌放射性口腔粘膜炎的有效防治措施。方法:選取2008年3月～2009年12月在廣西醫(yī)科大學(xué)第三附屬醫(yī)院腫瘤科就診的鼻咽癌患者58例,全部病例均已經(jīng)病理證實(shí)。將58例鼻咽癌患者采用抽簽法隨機(jī)分為三乙醇胺組(n = 30)及對照組(n = 28),三乙醇胺組于放療第一天開始,每次放療結(jié)束后用30%三乙醇胺乳膏混合液(10ml生理鹽水+3克三乙醇胺乳膏,自配)含漱,含漱液在口腔內(nèi)保持10～15分鐘,早晚各含漱一次,至放療結(jié)束。放療中患者出現(xiàn)II級及以上口腔粘膜炎時予常規(guī)處理。對照組只用生理鹽水含漱,當(dāng)患者出現(xiàn)II級及以上口腔粘膜炎時予三乙醇胺組同樣處理。結(jié)果:1.三乙醇胺組和對照組患者的I級粘膜炎發(fā)生率分別為46.7%和3.60%,III級粘膜炎發(fā)生率分別為16.7%和42.8%,其差異有統(tǒng)計學(xué)意義(P 0.05);2.在照射劑量達(dá)20Gy及30Gy時,三乙醇胺組口腔粘膜炎發(fā)生率分別為33.3%(10例)和63.4%(19例),而對照組分別為78.5%(22例)和21.5%(6例),其差異均有統(tǒng)計學(xué)意義(P 0.05); 3.兩組出現(xiàn)放射性口腔粘膜炎的時間:三乙醇胺組12～27天,中位18天,對照組5～22天,中位11天,三乙醇胺組明顯晚于對照組。4.III級粘膜炎平均持續(xù)時間分別為8.2天和11.4天,差異有統(tǒng)計學(xué)意義(P 0.05)。結(jié)論:三乙醇胺乳膏混合液含漱對防治放射性口腔粘膜炎有較好的效果,明顯推遲口腔粘膜反應(yīng)出現(xiàn)時間,縮短粘膜修復(fù)時間,粘膜反應(yīng)程度多為Ⅰ級,其取材方便,無毒副作用,值得臨床推廣應(yīng)用。
[Abstract]:Background and objective: acute radiation oral mucositis is the most common side effect during radiotherapy for nasopharyngeal carcinoma (NPC).The purpose of this study was to investigate the effective prevention and treatment of nasopharyngeal carcinoma (NPC) radiation oral mucositis.Methods: from March 2008 to December 2009, 58 patients with nasopharyngeal carcinoma were selected from Department of Oncology, third affiliated Hospital of Guangxi Medical University.58 patients with nasopharyngeal carcinoma were randomly divided into triethanolamine group (n = 30) and control group (n = 28).After each radiotherapy, the mixture of 30% triethanolamine cream and 10 ml normal saline 3 g triethanolamine cream was used to gargle. The gargle was kept in the mouth for 1015 minutes, once in the morning and evening, until the end of radiotherapy.Patients with grade II or above oral mucositis during radiotherapy were treated routinely.The control group was gargled only with normal saline, and the triethanolamine group was treated with triethanolamine when the patients developed grade II or above oral mucositis.The result is 1: 1.The incidence of grade I mucositis in triethanolamine group and control group was 46.7% and 3.60%, respectively. The incidence of grade III mucositis was 16.7% and 42.8%, respectively. The difference was statistically significant (P 0.05).The incidence of oral mucositis in triethanolamine group was 33.3% (10 cases) and 63.4% (19 cases), while that in control group was 78.5% (22 cases) and 21.5% (6 cases).The mean duration of oral mucositis in the triethanolamine group was 8.2 days later than that in the control group (8.2 days and 11.4 days, respectively), with a median of 18 days, 522 days in the control group and 11 days in the control group, and the mean duration of oral mucositis in the triethanolamine group was 8.2 days and 11.4 days, respectively.The difference was statistically significant (P 0.05).Conclusion: the mixture of triethanolamine cream gargle has a better effect on prevention and treatment of radioactive oral mucositis. It can obviously delay the time of oral mucosal reaction and shorten the time of mucosal repair.No toxic side effects, worthy of clinical application.
【學(xué)位授予單位】：廣西醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2010
【分類號】：R739.63

【引證文獻(xiàn)】

相關(guān)碩士學(xué)位論文 前1條

1 萬能;自擬養(yǎng)陰清熱湯預(yù)防陰虛毒熱型鼻咽癌急性放射口腔黏膜反應(yīng)的臨床觀察[D];湖南中醫(yī)藥大學(xué);2011年

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