本文選題：RTVue　切入點：OCT　出處：《眼科新進展》2014年09期

【摘要】：目的采用RTVue OCT測量正常人和青光眼患者的視網(wǎng)膜神經(jīng)纖維層(retinal nerve fiber layer,RNFL)厚度以及視盤的各項參數(shù)并進行分析,探討頻域OCT在青光眼診斷中的作用。方法收集正常人40例(40眼)、原發(fā)性開角型青光眼(primary open-angle glaucoma,POAG)早中期患者30例(30眼)、POAG晚期患者38例(38眼),OCT測量所有研究對象視盤各參數(shù)、視盤各象限的RNFL厚度、平均RNFL厚度。對各參數(shù)與視野平均缺損(mean defect,MD)值進行相關(guān)分析,對檢測結(jié)果進行評價。結(jié)果 OCT檢測結(jié)果表明,正常組和POAG早中期組、POAG晚期組上方、顳側(cè)、下方、鼻側(cè)象限RNFL厚度和平均RNFL厚度的差異均有統(tǒng)計學(xué)意義(均為P=0.000),各組RNFL厚度從厚到薄依次為視盤下方、上方、顳側(cè)、鼻側(cè)象限。在視盤形態(tài)參數(shù)中,正常組、POAG早中期組和POAG晚期組患者視杯面積、盤沿面積、盤沿容積、視杯容積、視盤容積、杯盤面積比、水平杯盤比以及垂直杯盤比之間的差異均有統(tǒng)計學(xué)意義(均為P=0.000),組間兩兩比較差異也均有統(tǒng)計學(xué)意義(均為P0.05);而視盤面積差異無統(tǒng)計學(xué)意義(P=0.497)。對POAG患者的檢測表明,視盤上方、顳側(cè)、下方象限RNFL厚度以及平均RNFL厚度與視野MD值之間存在著負相關(guān)關(guān)系(r=-0.455、-0.211、-0.493、-0.425,均為P0.05),而鼻側(cè)象限RNFL厚度與視野MD值無相關(guān)性(r=-0.106,P0.05);視盤參數(shù)中,視杯面積和杯盤面積比與視野MD值呈正相關(guān)(r=0.057、0.394,均為P0.05),而盤沿面積、盤沿容積和視盤容積與視野MD值呈負相關(guān)(r=-0.275、-0.306、-0.418,均為P0.05)。結(jié)論 RNFL厚度和視盤各參數(shù)是早期青光眼的敏感指標,RTVue OCT檢測RNFL厚度和視盤參數(shù)有助于青光眼早期診斷。
[Abstract]:Objective to measure and analyze the thickness of retinal nerve fiber layerus and the parameters of optic disc in normal subjects and glaucoma patients by RTVue OCT. To investigate the role of frequency-domain OCT in the diagnosis of glaucoma. Methods 40 normal subjects (40 eyes) and 30 patients (30 eyes) with primary open angle glaucoma (PCG) in early and middle stage were studied by Oct. The parameters of optic disc were measured by Oct in 38 patients (38 eyes) with late stage of Poag. The RNFL thickness and mean RNFL thickness of each quadrant of the optic disc were analyzed and the results were evaluated by correlation analysis between the parameters and the mean mean mean defectMD value of the visual field. Results the results of OCT test showed that the normal group and the early and middle POAG group were superior to the late Poag group and the temporal side. The difference of RNFL thickness and average RNFL thickness in nasal quadrant was statistically significant (P < 0. 000). The thickness of RNFL in each group was below, above, temporal and nasal quadrants from thickness to thickness. The visual cup area, disc edge area, disc edge volume, visual cup volume, optic disc volume, cup area ratio of patients with Poag in early and middle stage group and late POAG group were measured. The difference of horizontal cup / disc ratio and vertical cup / disc ratio was statistically significant (both P0. 000 and P 0. 05), but there was no significant difference in optic disc area between the two groups (P 0. 05, P 0. 497). The examination of the patients with POAG showed that above the optic disc, there was no significant difference in the area of the optic disc, and there was no significant difference in the area of the optic disc between the two groups (P < 0. 05). There was a negative correlation between the thickness of RNFL in temporal and inferior quadrants and the mean thickness of RNFL and the MD value of visual field. There was a negative correlation between the thickness of RNFL in the nasal quadrant and the MD value of the visual field, and there was no correlation between the thickness of RNFL in the nasal quadrant and the MD value of the visual field, and there was no correlation between the thickness of RNFL in the nasal quadrant and the MD value of the visual field, and in the optic disk parameters, there was no correlation between the thickness of RNFL in the nasal quadrant and the value of MD. There was a positive correlation between the visual cup area and the area ratio of cup and disc and the MD value of visual field. There was a negative correlation between the disc volume and visual disc volume and the MD value of visual field, both of which were P0.05.Conclusion the thickness of RNFL and the parameters of optic disc are sensitive indexes of early glaucoma. The thickness of RNFL and the parameters of optic disc are helpful for the early diagnosis of glaucoma.
【作者單位】： 常熟市第二人民醫(yī)院眼科;
【分類號】：R775

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本文編號：1661980