本文選題：原發(fā)性青光眼　切入點(diǎn)：型糖尿病　出處：《眼科新進(jìn)展》2015年02期 　論文類型：期刊論文

【摘要】：目的探討基質(zhì)金屬蛋白酶2(matrix metalloproteinase-2,MMP-2)及金屬蛋白酶2組織抑制因子(tissue inhibitor of metalloproteinase-2,TIMP-2)與原發(fā)性青光眼合并2型糖尿病的關(guān)系。方法研究對象分A組、B組、C組、D組、E組、F組6組,每組30眼。A組為原發(fā)性開角型青光眼(primary open angle glaucoma,POAG)組,B組為原發(fā)性閉角型青光眼(primary angle closure glaucoma,PACG)組,C組為POAG合并2型糖尿病組,D組為PACG合并2型糖尿病組,E組為糖尿病性白內(nèi)障組,F組為年齡相關(guān)性白內(nèi)障組。采用酶聯(lián)免疫吸附試驗(yàn)檢測各組房水及血清中TIMP-2及MMP-2的含量,并計(jì)算TIMP-2/MMP-2值。結(jié)果在6組研究對象的房水中,MMP-2濃度在A組為(24.92±6.62)μg·L-1、B組為(36.80±15.07)μg·L-1、D組為(28.44±5.78)μg·L-1,均較F組的(22.87±3.54)μg·L-1顯著升高(均為P0.05);同時房水中TIMP-2濃度在A組為(43.92±19.57)μg·L-1、B組為(76.13±27.67)μg·L-1、D組為(61.92±6.51)μg·L-1,也均較F組的(22.48±3.56)μg·L-1顯著升高(均為P0.05)。A、B、C、D組房水中TIMP-2/MMP-2值較E組和F組顯著提高,約為其2倍,但A組、B組、C組、D組間TIMP-2/MMP-2值無顯著性差異。在6組研究對象的血清中,A組MMP-2和TIMP-2濃度最高,分別為(396.75±49.30)μg·L-1和(337.67±62.78)μg·L-1,其余各組間MMP-2和TIMP-2濃度無顯著性差異。6組研究對象血清中TIMP-2/MMP-2值無明顯差異。結(jié)論原發(fā)性青光眼患者中TIMP-2/MMP-2值均存在失衡,說明MMP-2的活性變化及TIMP-2/MMP-2值與POAG和PACG的發(fā)病密切相關(guān),但2型糖尿病對原發(fā)性青光眼的病程進(jìn)展無明顯影響。
[Abstract]:Objective to investigate the relationship between matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-2 (TIMP-2) and primary glaucoma complicated with type 2 diabetes mellitus. 30 eyes of group A: primary open angle glaucoma: primary open angle glaucoma group (group B, primary angle closure glaucoma, primary angle closure glaucoma group), group C, POAG combined with type 2 diabetes, group D, PACG, combined with type 2 diabetes, group E, diabetic whitening, group B, group B: primary angle closure glaucoma, primary angle closure glaucoma group, group C, group C, POAG combined with type 2 diabetes, group D, PACG, combined with type 2 diabetes, group B, group B, primary angle closure glaucoma. The contents of TIMP-2 and MMP-2 in aqueous humor and serum were detected by enzyme linked immunosorbent assay (Elisa). Results the concentration of MMP-2 in aqueous humor in group A was 24.92 鹵6.62 渭 g 路L -1, and that in group B was 36.80 鹵15.07 渭 g 路L -1, which was 28.44 鹵5.78 渭 g 路L -1, which was significantly higher than that in group F (22.87 鹵3.54) 渭 g 路L -1, and the concentration of TIMP-2 in aqueous humor was 43.92 鹵19.57 渭 g 路L -1 in group A, 76.13 鹵27.67 渭 g 路L -1 in group B, 61.92 鹵6.51 渭 g 路L -1 in group D and 61.92 鹵6.51 渭 g 路L -1 in group D, respectively. The concentration of TIMP-2/MMP-2 in aqueous humor of group D was significantly higher than that of group E and group F (P 0.05 鹵3.56) 渭 g 路L -1. But there was no significant difference in TIMP-2/MMP-2 between C and D groups. The serum MMP-2 and TIMP-2 concentrations of group A were the highest among the six groups. The concentrations of MMP-2 and TIMP-2 were 396.75 鹵49.30 渭 g 路L -1 and 337.67 鹵62.78 渭 g 路L -1, respectively. There was no significant difference in the concentration of MMP-2 and TIMP-2 between other groups. The results showed that the changes of MMP-2 activity and TIMP-2/MMP-2 value were closely related to the onset of POAG and PACG, but type 2 diabetes had no significant effect on the progression of primary glaucoma.
【作者單位】： 贛南醫(yī)學(xué)院第一附屬醫(yī)院眼科;
【基金】：江西省科技支撐計(jì)劃項(xiàng)目(編號:20122BBG70156-1)~~
【分類號】：R775;R587.1

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