本文選題：冠心病　切入點(diǎn)：睡眠呼吸暫停　出處：《浙江大學(xué)》2010年碩士論文　論文類型：學(xué)位論文

【摘要】： 目的：探討冠心病(coronary artery disease, CAD)與阻塞性睡眠呼吸暫停低通氣綜合征(obstructive sleep apnea syndrome, OSAS)之間的相關(guān)性。 方法：選擇2008年6月至2009年3月因胸悶胸痛及夜間心絞痛疑診冠心病來我院心內(nèi)科住院的52例患者,監(jiān)測(cè)生命體征,行冠狀動(dòng)脈造影,冠脈造影前或后進(jìn)行睡眠監(jiān)測(cè)�？崭钩檠獪y(cè)甘油三酯,膽固醇水平,行心電圖、超聲心動(dòng)圖檢查,計(jì)算體重指數(shù)(body mass index, BMI)及了解有無患高血壓、糖尿病情況。 結(jié)果：將患者分成對(duì)照組(冠脈造影陰性),冠心病組(冠脈造影陽性)。對(duì)照組21例,其中OSAS 13例(61.9%),冠心病組31例,OSAS 25例(80.6%)。統(tǒng)計(jì)分析兩組之間睡眠呼吸紊亂指數(shù)、最低氧飽和度及定量評(píng)估冠脈狹窄程度(Gensini評(píng)分)、甘油三酯水平差異有統(tǒng)計(jì)學(xué)意義(P0.05)。兩組之間膽固醇水平,高血壓和糖尿病的患病率差異沒有統(tǒng)計(jì)學(xué)意義。Logistic回歸分析得出,吸煙和AHI20為冠心病發(fā)病的危險(xiǎn)因素,OR值分別為6.603和4.883。結(jié)論：冠心病和阻塞型睡眠呼吸暫停低通氣綜合征密切相關(guān),AHI20是冠心病的危險(xiǎn)因素之一,應(yīng)引起足夠的重視。
[Abstract]:Objective: To investigate the correlation between coronary artery disease (CAD) and obstructive sleep apnea syndrome (OSAS) in patients with obstructive sleep apnea hypopnea syndrome.
Methods: 52 cases from June 2008 to March 2009 because of chest pain and nocturnal angina suspected coronary heart disease in our hospital department of Cardiology hospitalized patients, monitoring the vital signs, coronary angiography, coronary angiography before and after sleep monitoring. Fasting blood test triglyceride, cholesterol level, electrocardiogram, echocardiography, body mass index (body mass index, BMI) and know whether the risk of high blood pressure, diabetes.
Results: the patients were divided into control group (CAG), coronary heart disease group (positive coronary angiography). The control group of 21 cases, including 13 cases of OSAS (61.9%), 31 cases of coronary heart disease, 25 cases of OSAS (80.6%). Statistical analysis between the two groups of sleep apnea hypopnea index, the lowest oxygen saturation and quantitative assessment of coronary artery stenosis degree (Gensini score), statistically significant differences in the level of triglyceride (P0.05) between the two groups. Cholesterol levels, prevalence of hypertension and diabetes was not statistically significant.Logistic regression analysis showed that smoking and AHI20 are the risk factors of coronary artery disease, OR = 6.603 and 4.883. conclusion: coronary heart disease and obstructive sleep apnea hypopnea syndrome is closely related, AHI20 is one of the risk factors of coronary heart disease, should cause enough attention.

【學(xué)位授予單位】：浙江大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2010
【分類號(hào)】：R766;R541.4

【參考文獻(xiàn)】

相關(guān)期刊論文 前4條

1 吳學(xué)勤,葉非常,余鋒,梅楨峰;阻塞性睡眠呼吸暫停患者的心律失常特點(diǎn)及與體位變化的關(guān)系[J];中國(guó)心臟起搏與心電生理雜志;1999年02期

2 張希龍,殷凱生,王虹,賈恩志,楊玉;阻塞性睡眠呼吸暫停低通氣綜合征與代謝綜合征相關(guān)機(jī)制的探討[J];中華結(jié)核和呼吸雜志;2004年09期

3 ;睡眠呼吸暫停人群高血壓患病率的多中心研究[J];中華結(jié)核和呼吸雜志;2007年12期

4 陸丕能,孫寧玲,陸捚,盧明喻;吸煙量與冠心病關(guān)系的病例對(duì)照研究[J];中華流行病學(xué)雜志;2002年04期

，

本文編號(hào)：1567266