本文關(guān)鍵詞： 飛秒激光 角膜移植術(shù) meta-分析　出處：《重慶醫(yī)科大學(xué)》2014年碩士論文　論文類型：學(xué)位論文

【摘要】：目的本文旨在用meta分析觀察飛秒激光輔助角膜移植手術(shù)的療效及其安全性,并與傳統(tǒng)角膜移植手術(shù)進行比較。 方法采用Cochrane系統(tǒng)評價方法，計算機檢索PubMed, Embase,Cochrane Central和OVID等英文數(shù)據(jù)庫，符合入選標準的文獻由2名評價者獨立依據(jù)“Cochrane偏倚風(fēng)險評估工具”評價RCT研究，依據(jù)“MINORS”標準評價非RCT研究，并交叉核對納入研究的質(zhì)量，采用RevMan5.2.6軟件進行meta分析。 結(jié)果7篇文獻被納入meta分析，結(jié)果顯示飛秒激光輔助角膜移植術(shù)與傳統(tǒng)角膜移植術(shù)的術(shù)后短期散光值(MD=-1.59,95%CI [-2.86,-0.31], P=0.01)和長期散光值(MD=-1.17,95%CI [-1.97,-0.38], P=0.004)的差異有統(tǒng)計學(xué)意義，但飛秒激光在術(shù)后短期最佳矯正視力(MD=0.01,95%CI [-46,0.48], P=0.96)、長期最佳矯正視力(MD=0.10,95%CI [-0.06,0.26], P=0.23)、排斥率(RR=0.57,95%CI [0.13,2.49], P=0.46)及移植失敗率(RR=1.74,95%CI [0.74,4.07], P=0.2)方面與傳統(tǒng)角膜移植術(shù)相比差異無統(tǒng)計學(xué)意義。 結(jié)論與傳統(tǒng)角膜移植術(shù)相比，，飛秒激光輔助角膜移植術(shù)能明顯降低術(shù)后散光，但不能提高術(shù)后最佳矯正視力。兩種手術(shù)方式的排斥率和移植失敗率均較低且沒有明顯差異。
[Abstract]:Objective to observe the efficacy and safety of femtosecond laser assisted keratoplasty by meta and compare it with traditional keratoplasty. Methods Cochrane system was used to search the English database of PubMed, Embase Cochrane Central and OVID. According to the selection criteria, the RCT study was evaluated by two evaluators independently according to the Cochrane bias risk Assessment tool, and the non-#en6# study was evaluated according to the MINORS criteria. And cross-check into the quality of the study, using RevMan5.2.6 software for meta analysis. Results Seven articles were included in the meta analysis. The results showed that there were significant differences in short-term astigmatism between femtosecond laser assisted keratoplasty and conventional keratoplasty, such as MD-1.59 ~ 95CI [-2.86 ~ 0.31, P ~ (0.01)] and long-term astigmatism: MD-1.17 ~ 95CI [-1.97 -0.38], P _ (0.004). However, femtosecond laser has no significant difference compared with traditional keratoplasty in terms of short-term best corrected visual acuity (BCVA): MD0.01 + 95CI [-46 鹵0.48], P0. 96, MD0.1095 + CI [-0.060.26], P0. 23T, rejection rate: RRV 0.5795CI [0.132.49, P0. 46) and the failure rate of transplantation (RRRV 1.7495CI [0.744.07], P0.2c). Conclusion compared with traditional keratoplasty, femtosecond laser assisted keratoplasty can significantly reduce postoperative astigmatism, but can not improve the postoperative best corrected visual acuity.
【學(xué)位授予單位】：重慶醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R779.65

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相關(guān)期刊論文 前1條

1 高嵩,張小玲,孫文濤;飛秒激光在基質(zhì)內(nèi)屈光手術(shù)中的應(yīng)用[J];國際眼科雜志;2005年04期

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