本文關鍵詞： 鼻咽癌 胸苷磷酸化酶 化療 預后　出處：《南昌大學》2011年碩士論文　論文類型：學位論文

【摘要】：目的： 探討胸苷磷酸化酶(thymidine phosphorylase, TP)在鼻咽癌中的表達及臨床意義。 方法： 采用免疫組化方法(Elivision法)檢測了51例鼻咽癌組織和10例鼻粘膜炎及10例鼻息肉組織中TP的表達,并探討鼻咽癌組織中胸苷磷酸化酶與臨床病理因素、氟尿嘧啶類藥物化療療效及預后之間的關系。 結果： (1)在51例鼻咽癌組織中,有35例(68.8%)TP表達陽性,與鼻粘膜炎及鼻息肉組織中的TP表達(分別為30%和20%)差異顯著(P值分別為0.032和0.01)。 (2)鼻咽癌組織中TP表達與年齡、性別、T分期、N分期、TNM分期、顱神經侵犯、復發(fā)或遠處轉移等臨床病理因素均無明顯相關性(P0.05) (3)對行含氟尿嘧啶類藥物方案化療的鼻咽癌亞群進行生存分析,TP陽性組與TP陰性組的總生存率差異無顯著性意義(P值為0.685) (4)對51例鼻咽癌病人進行生存分析,TP陽性組與TP陰性組的3年、4年總生存率差異無顯著性意義。多因素Cox模型分析顯示復發(fā)或遠處轉移為影響鼻咽癌預后的獨立因素,TP表達不是影響鼻咽癌預后的獨立因素。 結論： TP在鼻咽癌組織中高表達,明顯高于鼻粘膜炎及鼻息肉組織中TP的表達量。鼻咽癌組織中的TP表達與臨床病理因素均無明顯相關性。行含氟尿嘧啶類藥物方案化療的鼻咽癌亞群中TP陽性組與TP陰性組的預后差異無顯著性意義,多因素Cox模型分析顯示TP表達并非是影響鼻咽癌預后的獨立因素。
[Abstract]:Objective:. To investigate the expression and clinical significance of thymidine phosphorylase (TP) in nasopharyngeal carcinoma (NPC). Methods:. The expression of TP in 51 cases of nasopharyngeal carcinoma (NPC), 10 cases of nasal mucositis and 10 cases of nasal polyps was detected by immunohistochemical method. Relationship between chemotherapy efficacy and prognosis of fluorouracil drugs. Results:. (1) in 51 cases of nasopharyngeal carcinoma, there were 35 cases with positive expression of TP, which was significantly different from that in nasal mucositis and nasal polyps (30% and 20) (P = 0.032 and 0.01, respectively). (2) there was no significant correlation between TP expression in nasopharyngeal carcinoma and age, sex T staging, TNM stage, cranial nerve invasion, recurrence or distant metastasis (P 0.05). Survival analysis of nasopharyngeal carcinoma subsets treated with fluorouracil regimen; there was no significant difference in overall survival rate between TP positive group and TP negative group (P = 0.685). Survival analysis of 51 patients with nasopharyngeal carcinoma the 3-year and 4-year overall survival rates of TP positive group and TP negative group were not significantly different. Multivariate Cox model analysis showed that recurrence or distant metastasis was an independent factor affecting the prognosis of nasopharyngeal carcinoma. The expression of TP is not an independent factor for the prognosis of nasopharyngeal carcinoma. Conclusion:. TP was highly expressed in nasopharyngeal carcinoma. There was no significant correlation between TP expression and clinicopathological factors in nasopharyngeal carcinoma. TP positive group in nasopharyngeal carcinoma subpopulation with fluorouracil regimen chemotherapy was significantly higher than that in nasal polyps and nasal mucositis tissues, and there was no significant correlation between TP expression and clinicopathological factors in nasopharyngeal carcinoma tissues. There was no significant difference in prognosis between TP negative group and TP negative group. Multivariate Cox analysis showed that TP expression was not an independent factor for the prognosis of nasopharyngeal carcinoma.
【學位授予單位】：南昌大學
【學位級別】：碩士
【學位授予年份】：2011
【分類號】：R739.63

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