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  本文關鍵詞： 功能磁共振成像 屈光參差 弱視 靜息狀態(tài) 功能連接　出處：《天津醫(yī)科大學》2010年碩士論文　論文類型：學位論文

【摘要】： 目的： 運用功能磁共振成像(functional magnetic resonance imaging, fMRI)技術,采用種子點功能連接方法分析屈光參差性弱視患者和正常人在靜息狀態(tài)下不同腦區(qū)間相關性的差異。 材料與方法： 選擇左眼屈光參差性弱視患者13例,正常對照組17例。采用GE 1.5T磁共振掃描儀對所有被試進行靜息態(tài)fMRI研究。應用AFNI、Matlab、SPM軟件進行預處理和統(tǒng)計分析。預處理包括時間校正、頭動校正、空間標準化、空間平滑、去線性漂移、低通濾波和去除協(xié)變量。選擇左側BA19區(qū)(-30、-75、42)作為功能連接種子點進行分析,對其與全腦其它腦區(qū)所有體素的時間序列做相關分析,產(chǎn)生一個空間的互相關圖(功能連接模式圖)。采用單樣本t-檢驗和雙樣本t-檢驗進行組內(nèi)和組間分析。統(tǒng)計參數(shù)圖疊加到MNI標準三維模板腦進行顯示,用已知的神經(jīng)解剖學標記來描述與左側BA19(-30、-75、42)區(qū)有顯著相關的區(qū)域。觀察有統(tǒng)計學意義的團塊(mass)的大小、所在腦區(qū)及其坐標(MNI坐標)。記錄相關區(qū)的體積(cluster)及相關強度(用t檢驗統(tǒng)計值“T”表示,T值越大,相關性越強)。 結果： 在嚴格控制被試頭動、行為學表現(xiàn)及機械噪聲等因素影響后,最終符合實驗要求的被試為左眼屈光參差性弱視患者12例,正常人16例。為達到組間性別及年齡的匹配,選擇左眼屈光參差性弱視患者組和正常對照組內(nèi)各12例進行分析,以保證實驗結果的可靠性。 正常對照組與左側BA19區(qū)正相關的腦區(qū)主要為：右側小腦半球、雙側梭狀回、雙側顳中回、雙側顳下回、雙側額上回、雙側楔前葉、雙側頂上小葉、雙側頂下小葉、雙側扣帶回后部、雙側額中回；左眼屈光參差性弱視患者組與左側BA19區(qū)正相關的腦區(qū)有：右側小腦半球、左側梭狀回、左側額下回、雙側額中回、雙側楔前葉、雙側頂上小葉、雙側頂下小葉；正照對照組與左側BA19區(qū)的正相關性高于患者組的腦區(qū)主要包括：左側小腦半球、右側尾狀核、左側額中回、左側頂上小葉、左側頂下小葉、左側額上回。 結論： 1.正常人在靜息狀態(tài)下存在與左側BA19區(qū)具有相關性的神經(jīng)網(wǎng)絡； 2.左眼屈光參差性弱視患者左側小腦半球、右側尾狀核、左側額中回、左側頂上小葉、左側頂下小葉、左側額上回與左側BA19區(qū)功能連接程度減低,可能是左眼屈光參差性弱視患者的發(fā)生機制之一。
[Abstract]:Objective:. Functional magnetic resonance imaging (fMRI) technique was used to analyze the correlation between anisometropia amblyopia and normal subjects in different brain regions. Materials and methods:. Thirteen cases of anisometropia amblyopia in left eye and 17 cases of normal control group were selected. All subjects were studied by GE 1.5T magnetic resonance scanner in resting state fMRI. The pretreatment and statistical analysis were performed with AFNINT-Matlab-SPM software. The pretreatment included time correction. Head-moving correction, spatial standardization, spatial smoothing, de-linear drift, low-pass filtering and removal of covariates. Select the left BA19 region -30- 75N42as the functional connection seed point for analysis, Correlation analysis was made between the time series and all voxels in other brain regions of the whole brain. Generating a spatial cross-correlation map (functional connection pattern map). Using single-sample t-test and double-sample t-test for intra-group and inter-group analysis. The statistical parameter map is superimposed on the MNI standard three-dimensional template brain for display. The known neuroanatomical markers were used to describe the areas significantly related to the left side of the mass mass, BA19 ~ (-30) ~ (-75) ~ (42). The size of a statistically significant mass was observed. In the brain area and its coordinate, MNI coordinate, the volume of correlation area is recorded and the correlation strength is recorded. The statistical value "T" of t test indicates that the greater the value of T is, the stronger the correlation is. Results:. After strictly controlling the effects of the factors such as head movement, behavioral performance and mechanical noise, the subjects who met the experimental requirements were 12 patients with anisometropic amblyopia of left eye and 16 normal subjects. 12 cases of anisometropia amblyopia in left eye and 12 cases of normal control group were analyzed to ensure the reliability of the experimental results. In the control group, the positive correlation between the left BA19 and the right cerebellar hemisphere, bilateral fusiform gyrus, bilateral middle temporal gyrus, bilateral infratemporal gyrus, bilateral superior frontal gyrus, bilateral anterior cuneate lobe, bilateral superior parietal lobule, bilateral inferior parietal lobule were observed. The right cerebellar hemisphere, left fusiform gyrus, left inferior frontal gyrus, bilateral middle frontal gyrus, bilateral anterior wedge lobe, bilateral superior parietal lobule, left cerebellar hemisphere, left fusiform gyrus, bilateral frontal gyrus, bilateral anterior wedge lobe, bilateral parietal lobule, The positive correlation between the positive control group and the left BA19 area was higher than that in the patient group, including left cerebellar hemisphere, right caudate nucleus, left middle frontal gyrus, left superior parietal lobule, left inferior parietal lobule, left superior frontal gyrus, and left superior frontal gyrus. Conclusion:. 1. There is a neural network with correlation between the left BA19 region and the rest state. 2. Left cerebellar hemisphere, right caudate nucleus, left middle frontal gyrus, left superior parietal lobule, left inferior parietal lobule, left superior frontal gyrus, left superior frontal gyrus, left superior frontal gyrus and left BA19 area were decreased in patients with left anisometropic amblyopia. It may be one of the mechanisms of anisometropia amblyopia in the left eye.
【學位授予單位】：天津醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2010
【分類號】：R777.44

【引證文獻】

相關碩士學位論文 前1條

1 石彥杰;不同類型弱視兒童立體視皮層的功能磁共振研究[D];蘭州大學;2012年

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本文編號：1500411