本文關(guān)鍵詞：髓源性抑制細(xì)胞在鼻咽癌患者外周血及荷瘤小鼠體內(nèi)的水平及作用初探　出處：《免疫學(xué)雜志》2015年04期 　論文類型：期刊論文

  更多相關(guān)文章： 鼻咽癌 髓源性抑制細(xì)胞 細(xì)胞因子 免疫逃逸

【摘要】：目的探討髓源性抑制細(xì)胞(MDSCs)在鼻咽癌患者外周血中的表達水平及其臨床意義,并在荷瘤小鼠體內(nèi)探討MDSCs可能的作用。方法采用流式細(xì)胞術(shù)分析49例鼻咽癌患者外周血及荷瘤小鼠脾臟MDSCs的比例,采用ELISA分析鼻咽癌患者及荷瘤小鼠中MDSCs對T細(xì)胞分泌細(xì)胞因子的影響。結(jié)果鼻咽癌患者外周血中MDSCs的比例顯著高于健康對照組,并且鼻咽癌患者外周血中MDSCs的比例與腫瘤的分期有關(guān),晚期患者外周血中MDSCs的比例高于早期患者;鼻咽癌荷瘤小鼠脾臟內(nèi)MDSCs的數(shù)量明顯高于對照組;研究表明MDSCs可明顯抑制T細(xì)胞分泌細(xì)胞因子。結(jié)論鼻咽癌患者外周血中MDSCs的比例較健康人高,且與鼻咽癌分期密切相關(guān),荷瘤小鼠實驗表明腫瘤組小鼠脾臟MDSCs的數(shù)量明顯高于對照組,并且MDSCs可影響荷瘤小鼠細(xì)胞因子的分泌。MDSCs可能作為鼻咽癌生物治療的1個靶點。
[Abstract]:Objective to investigate the expression of myelogenous inhibitory cell (MDSCs) in peripheral blood of patients with nasopharyngeal carcinoma (NPC) and its clinical significance. Methods flow cytometry was used to analyze the proportion of MDSCs in peripheral blood and spleen of 49 patients with nasopharyngeal carcinoma. ELISA was used to analyze the effect of MDSCs on T cell cytokines secretion in nasopharyngeal carcinoma patients and tumor-bearing mice. Results the percentage of MDSCs in peripheral blood of NPC patients was significantly higher than that of healthy controls. The proportion of MDSCs in peripheral blood of patients with nasopharyngeal carcinoma was related to the stage of tumor, and the proportion of MDSCs in peripheral blood of patients with advanced stage was higher than that of patients with early stage. The amount of MDSCs in the spleen of nasopharyngeal carcinoma bearing mice was significantly higher than that of control group. Conclusion the proportion of MDSCs in peripheral blood of patients with nasopharyngeal carcinoma is higher than that of healthy people, and it is closely related to the stage of nasopharyngeal carcinoma. Tumor-bearing mice experiment showed that the number of spleen MDSCs in the tumor group was significantly higher than that in the control group. And MDSCs can affect cytokine secretion in tumor-bearing mice. MDSCs may be a target for nasopharyngeal carcinoma biotherapy.
【作者單位】： 解放軍第324醫(yī)院五官科;德州市人民醫(yī)院手術(shù)室;
【分類號】：R739.63
【正文快照】： 髓源性抑制細(xì)胞(myeloid-derived suppressorcells,MDSCs)是近年來發(fā)現(xiàn)的由骨髓前體細(xì)胞和未成熟的骨髓細(xì)胞組成的表型異質(zhì)性的細(xì)胞群,具有強大的免疫抑制功能,MDSCs可通過多種機制抑制T細(xì)胞免疫應(yīng)答,在腫瘤的免疫逃逸及腫瘤的進展中具有極其重要的作用[1-2]。近年來的文獻報

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