【摘要】：目的研究不同臨床類型冠心病(CHD)患者和正常人血清中趨化因子CXC配體(L)5蛋白的表達(dá)差異。方法酶聯(lián)免疫吸附法檢測59例CHD患者和23例正常人血清中CXCL5蛋白的表達(dá)。結(jié)果正常對照組、穩(wěn)定型心絞痛(SAP)組、不穩(wěn)定型心絞痛(UAP)組和急性心肌梗死(AMI)組血清中的CXCL5蛋白水平分別為(63.47±5.67)、(64.37±7.26)、(69.74±7.99)和(70.84±9.44)ng/ml,與正常對照組和SAP組比較,UAP組和AMI組顯著增高(P0.05);與血清CXCL5水平60 ng/ml組比較,CHD組血清CXCL5水平70 ng/ml組Gensini評分顯著增高(P0.05)。結(jié)論血清CXCL5水平與CHD病情具有相關(guān)性,其可能作用一個經(jīng)典的炎癥因子參與CHD進(jìn)程。檢測血清CXCL5的水平和針對CXCL5相關(guān)治療可為CHD的臨床診斷和治療提供新的標(biāo)志物和靶點(diǎn)。
[Abstract]:Objective to study the expression of chemokine CXC ligand (L) 5 protein in serum of patients with different clinical types of coronary heart disease (CHD) and normal controls. Methods enzyme-linked immunosorbent assay (Elisa) was used to detect the expression of CXCL5 protein in serum of 59 patients with CHD and 23 normal subjects. Results the serum CXCL5 protein levels in normal control group, stable angina pectoris (SAP) group, unstable angina pectoris (UAP) group and acute myocardial infarction (AMI) group were 63.47 鹵5.67), (64.37 鹵7.26, respectively. (6974 鹵7.99) and (70.84 鹵9.44) ng/ml, were significantly higher in UAP group and AMI group than those in normal control group and SAP group (P 0.05). Compared with the serum CXCL5 level of 60 ng/ml group, the serum CXCL5 level of the CHD group was significantly higher than that of the 70 ng/ml group (P0.05). Conclusion the level of serum CXCL5 is correlated with the condition of CHD, and it may play a role in the process of CHD by a classical inflammatory factor. Detection of serum CXCL5 level and CXCL5-related therapy can provide new markers and targets for clinical diagnosis and treatment of CHD.
【作者單位】： 佳木斯市中心醫(yī)院心內(nèi)科;
【分類號】：R541.4

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