內(nèi)皮唾液酸蛋白通過調(diào)節(jié)血管平滑肌細胞表型重建,促進動脈粥樣硬化
發(fā)布時間：2019-03-11 13:22
【摘要】：正動脈粥樣硬化是全球主要的致死原因,血管平滑肌細胞(vascular smooth muscle cells,VSMC)在動脈粥樣硬化的發(fā)病中起關(guān)鍵作用。內(nèi)皮唾液酸蛋白(CD248)已被認為是間質(zhì)細胞系細胞(包括腫瘤相關(guān)周細胞、肌成纖維細胞間質(zhì)和活化的VSMC)的激活標記物。因此,研究人員假設VSMC表達的內(nèi)皮唾液酸蛋白可以功能性地參與動脈粥樣硬化的發(fā)病。方法與結(jié)果:通過定量逆轉(zhuǎn)錄聚合酶鏈反應和免疫組化分
[Abstract]:Positive atherosclerosis is the leading cause of death in the world. Vascular smooth muscle cells (vascular smooth muscle cells,VSMC) play a key role in the pathogenesis of atherosclerosis. Endothelial sialic acid protein (CD248) has been considered to be an activation marker for stromal cell lines including tumor-associated pericytes, myofibroblast stroma and activated VSMC. Therefore, the researchers hypothesized that VSMC-expressed endothelial sialic acid protein could functionally participate in the pathogenesis of atherosclerosis. Methods and results: quantitative reverse transcription polymerase chain reaction (QRT-PCR) and immunohistochemical staining were performed.
【分類號】：R543.5
，
本文編號：2438313
[Abstract]:Positive atherosclerosis is the leading cause of death in the world. Vascular smooth muscle cells (vascular smooth muscle cells,VSMC) play a key role in the pathogenesis of atherosclerosis. Endothelial sialic acid protein (CD248) has been considered to be an activation marker for stromal cell lines including tumor-associated pericytes, myofibroblast stroma and activated VSMC. Therefore, the researchers hypothesized that VSMC-expressed endothelial sialic acid protein could functionally participate in the pathogenesis of atherosclerosis. Methods and results: quantitative reverse transcription polymerase chain reaction (QRT-PCR) and immunohistochemical staining were performed.
【分類號】：R543.5
，
本文編號：2438313
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