發(fā)布時(shí)間：2019-03-11 13:22

【摘要】：正動(dòng)脈粥樣硬化是全球主要的致死原因,血管平滑肌細(xì)胞(vascular smooth muscle cells,VSMC)在動(dòng)脈粥樣硬化的發(fā)病中起關(guān)鍵作用。內(nèi)皮唾液酸蛋白(CD248)已被認(rèn)為是間質(zhì)細(xì)胞系細(xì)胞(包括腫瘤相關(guān)周細(xì)胞、肌成纖維細(xì)胞間質(zhì)和活化的VSMC)的激活標(biāo)記物。因此,研究人員假設(shè)VSMC表達(dá)的內(nèi)皮唾液酸蛋白可以功能性地參與動(dòng)脈粥樣硬化的發(fā)病。方法與結(jié)果:通過定量逆轉(zhuǎn)錄聚合酶鏈反應(yīng)和免疫組化分
[Abstract]:Positive atherosclerosis is the leading cause of death in the world. Vascular smooth muscle cells (vascular smooth muscle cells,VSMC) play a key role in the pathogenesis of atherosclerosis. Endothelial sialic acid protein (CD248) has been considered to be an activation marker for stromal cell lines including tumor-associated pericytes, myofibroblast stroma and activated VSMC. Therefore, the researchers hypothesized that VSMC-expressed endothelial sialic acid protein could functionally participate in the pathogenesis of atherosclerosis. Methods and results: quantitative reverse transcription polymerase chain reaction (QRT-PCR) and immunohistochemical staining were performed.
【分類號(hào)】：R543.5
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本文編號(hào)：2438313