【摘要】：目的探討超小劑量地西他濱治療中危-1型骨髓增生異常綜合征的療效及副反應(yīng)。方法收集2016年1月至2017年1月中國(guó)醫(yī)科大學(xué)附屬盛京醫(yī)院血液科10例中危-1型骨髓增生異常綜合征患者的臨床資料。所有患者接受皮下注射地西他濱10 mg/d,第1~3天,第8、15、22天。32 d為1個(gè)療程。評(píng)估其療效及副反應(yīng)。結(jié)果 6例例存在MDS相關(guān)基因突變。1個(gè)療程結(jié)束時(shí)4例獲得了臨床改善,其中1例部分緩解(PR),3例血液學(xué)改善(HI),6例疾病穩(wěn)定(SD)。3例患者完成3個(gè)療程治療,療效評(píng)估顯示,2例獲得了臨床改善,1例(33.3%)完全緩解(CR),1例血液學(xué)改善,1例SD。出現(xiàn)骨髓抑制4例,白細(xì)胞減少1例,貧血1例,血小板減少3例;2例出現(xiàn)嚴(yán)重的血小板減少。結(jié)論超小劑量地西他濱治療中危-1型骨髓增生異常綜合征安全有效。
[Abstract]:Objective to evaluate the efficacy and side effects of ultra-low-dose dietabine in the treatment of moderate-risk-1 myelodysplastic syndromes. Methods from January 2016 to January 2017, the clinical data of 10 patients with type 1 myelodysplastic syndromes (MDS) in the Department of Hematology of Shengjing Hospital affiliated to China Medical University were collected. All patients were subcutaneously injected with desitabine for 10 mg/d, on day 1, 3, 815, 22 days, and 32 days as a course of treatment. Evaluate its curative effect and side effect. Results 6 cases had MDS related gene mutation, 4 cases had clinical improvement at the end of one course of treatment, and 1 case had partial remission (PR), 3 cases had hematological improvement (HI),. 6 patients with stable (SD). Completed 3 courses of treatment. The evaluation of curative effect showed that 2 cases had clinical improvement, 1 case (33.3%) had complete remission of (CR), 1 case had hematological improvement, and 1 case had SD.. Bone marrow suppression occurred in 4 cases, leukopenia in 1 case, anemia in 1 case, thrombocytopenia in 3 cases, and severe thrombocytopenia in 2 cases. Conclusion it is safe and effective to treat medium-risk-1 myelodysplastic syndrome with low dose of dicitabine.
【作者單位】： 中國(guó)醫(yī)科大學(xué)附屬盛京醫(yī)院血液科;
【基金】：中國(guó)醫(yī)科大學(xué)附屬盛京醫(yī)院精準(zhǔn)醫(yī)學(xué)項(xiàng)目資助
【分類(lèi)號(hào)】：R551.3

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