三甲胺-N-氧化物在動脈粥樣硬化發(fā)病機(jī)制中的研究進(jìn)展
發(fā)布時(shí)間：2018-12-27 18:37
【摘要】：腸道菌群的代謝產(chǎn)物三甲胺-N-氧化物(trimethylamine-N-oxide,TMAO)是一種新發(fā)現(xiàn)的心血管疾病的危險(xiǎn)因子。腸道菌群利用食物中的膽堿和左旋肉堿轉(zhuǎn)化為三甲胺(trimethylamine,TMA),三甲胺在肝酶中氧化為TMAO,降低TMA可以刺激巨噬細(xì)胞逆向轉(zhuǎn)運(yùn)膽固醇和抑制動脈粥樣硬化形成。TMAO生成素單加氧酶3(flavin-containing monooxygenase 3,FMO3)是膽固醇代謝和膽固醇逆向轉(zhuǎn)運(yùn)的工具,降低FMO3可以減緩膽囊分泌膽汁,延緩腸道對膽固醇的吸收,并限制合成氧化型膽固醇和膽固醇酯。血液中TMAO可上調(diào)巨噬細(xì)胞內(nèi)的清道夫受體,促使巨噬細(xì)胞內(nèi)膽固醇累積和泡沫細(xì)胞的形成,進(jìn)而促進(jìn)血管斑塊的形成并通過MAPK和細(xì)胞核因子κB通路促進(jìn)血管炎性反應(yīng)。TMAO集中作用于影響膽固醇代謝、胰島素抵抗、促進(jìn)血小板高聚集、增加血栓形成、促進(jìn)血管炎癥反應(yīng)及直接導(dǎo)致動脈斑塊形成等方面。降低TMAO水平可以潛在的預(yù)防或治療動脈粥樣硬化相關(guān)疾病,降低心腦血管疾病發(fā)病率。TMA/FMO3/TMAO通路是調(diào)節(jié)脂質(zhì)代謝和炎癥的主要通路。
[Abstract]:Trimethylamine-N-oxide (trimethylamine-N-oxide,TMAO), a metabolite of intestinal flora, is a new risk factor for cardiovascular disease. The intestinal flora uses choline and L-carnitine in food to convert to trimethylamine (trimethylamine,TMA), which is oxidized to TMAO, in the liver enzyme. Lowering TMA stimulates the reverse transport of cholesterol in macrophages and inhibits the formation of atherosclerosis. TMAO monooxygenase 3 (flavin-containing monooxygenase 3 FMO3) is a tool for cholesterol metabolism and cholesterol reverse transport. Lowering FMO3 can slow down gallbladder bile secretion, delay intestinal absorption of cholesterol, and limit the synthesis of oxidized cholesterol and cholesterol ester. TMAO in blood can up-regulate scavenger receptor in macrophages and promote cholesterol accumulation and foam cell formation in macrophages. In turn, it promotes the formation of vascular plaque and promotes vascular inflammatory response through MAPK and nuclear factor 魏 B. TMAO concentrates on affecting cholesterol metabolism, insulin resistance, platelet hyperaggregation and thrombus formation. Promote vascular inflammation and direct arterial plaque formation. Lowering the level of TMAO can potentially prevent or treat atherosclerotic diseases and reduce the incidence of cardiovascular and cerebrovascular diseases. TMA/FMO3/TMAO pathway is the main pathway to regulate lipid metabolism and inflammation.
【作者單位】： 廣州中醫(yī)藥大學(xué)第二臨床醫(yī)學(xué)院神經(jīng)內(nèi)科;廣東省中醫(yī)院珠海醫(yī)院神經(jīng)內(nèi)科;四川大學(xué)華西口腔醫(yī)院特診科;
【分類號】：R543.5
，
本文編號：2393449
[Abstract]:Trimethylamine-N-oxide (trimethylamine-N-oxide,TMAO), a metabolite of intestinal flora, is a new risk factor for cardiovascular disease. The intestinal flora uses choline and L-carnitine in food to convert to trimethylamine (trimethylamine,TMA), which is oxidized to TMAO, in the liver enzyme. Lowering TMA stimulates the reverse transport of cholesterol in macrophages and inhibits the formation of atherosclerosis. TMAO monooxygenase 3 (flavin-containing monooxygenase 3 FMO3) is a tool for cholesterol metabolism and cholesterol reverse transport. Lowering FMO3 can slow down gallbladder bile secretion, delay intestinal absorption of cholesterol, and limit the synthesis of oxidized cholesterol and cholesterol ester. TMAO in blood can up-regulate scavenger receptor in macrophages and promote cholesterol accumulation and foam cell formation in macrophages. In turn, it promotes the formation of vascular plaque and promotes vascular inflammatory response through MAPK and nuclear factor 魏 B. TMAO concentrates on affecting cholesterol metabolism, insulin resistance, platelet hyperaggregation and thrombus formation. Promote vascular inflammation and direct arterial plaque formation. Lowering the level of TMAO can potentially prevent or treat atherosclerotic diseases and reduce the incidence of cardiovascular and cerebrovascular diseases. TMA/FMO3/TMAO pathway is the main pathway to regulate lipid metabolism and inflammation.
【作者單位】： 廣州中醫(yī)藥大學(xué)第二臨床醫(yī)學(xué)院神經(jīng)內(nèi)科;廣東省中醫(yī)院珠海醫(yī)院神經(jīng)內(nèi)科;四川大學(xué)華西口腔醫(yī)院特診科;
【分類號】：R543.5
，
本文編號：2393449
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