【摘要】：目的 探討尿液巰基化合物檢測(cè)作為子宮頸癌早期篩查手段的可行性。方法 收集144例就診者尿液作為對(duì)照組,其中包括健康體檢結(jié)果正常人員104例、陰道炎患者20例、人乳頭瘤病毒(HPV)感染者20例;確診子宮頸癌等婦科腫瘤患者的尿液標(biāo)本107例作為研究組。取1 m L新鮮尿液作為標(biāo)本,使用化學(xué)顯色法對(duì)標(biāo)本進(jìn)行巰基化合物含量檢測(cè),并以宮頸活檢的組織病理學(xué)為金標(biāo)準(zhǔn),評(píng)價(jià)尿液中巰基含量檢測(cè)在子宮頸癌篩查中的臨床價(jià)值。結(jié)果 在研究組中陽(yáng)性反應(yīng)有98例,陽(yáng)性率為91.6%;健康對(duì)照組中人員無(wú)陽(yáng)性反應(yīng);陰道炎患者陽(yáng)性反應(yīng)有5例,陽(yáng)性率為25%;HPV感染者陽(yáng)性反應(yīng)有12例,陽(yáng)性率為60%;研究組與健康對(duì)照組之間尿液巰基檢測(cè)陽(yáng)性率差異有統(tǒng)計(jì)學(xué)意義(P0.01)。結(jié)論 尿液中巰基化合物檢測(cè)對(duì)子宮頸癌及癌前病變篩查具有較高的敏感度,該方法簡(jiǎn)便、快速,適用于子宮頸癌的早期篩查。
[Abstract]:Objective to investigate the feasibility of urine thiol compound detection as an early screening method for cervical cancer. Methods 144 cases of urine were collected as control group, including 104 normal subjects, 20 patients with vaginitis and 20 patients with human papillomavirus (HPV) infection. Urine samples from 107 patients with cervical cancer and other gynecologic tumors were used as the study group. Using 1 mL fresh urine as a specimen, the content of sulfhydryl compounds was detected by chemical colorimetry, and the clinical value of the detection of thiol in urine in cervical cancer screening was evaluated with the histopathology of cervical biopsy as the gold standard. Results in the study group, 98 cases were positive, the positive rate was 91.6; in the healthy control group, there was no positive reaction; in vaginitis, there were 5 cases of positive reaction, and the positive rate was 25 cases of HPV infection in 12 cases. The positive rate was 60. There was significant difference between the study group and the healthy control group (P0.01). Conclusion the detection of sulfhydryl compounds in urine is sensitive to the screening of cervical cancer and precancerous lesions. This method is simple, rapid and suitable for early screening of cervical cancer.
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本文編號(hào)：2293894