【摘要】：目的 探討尿液巰基化合物檢測作為子宮頸癌早期篩查手段的可行性。方法 收集144例就診者尿液作為對照組,其中包括健康體檢結(jié)果正常人員104例、陰道炎患者20例、人乳頭瘤病毒(HPV)感染者20例;確診子宮頸癌等婦科腫瘤患者的尿液標本107例作為研究組。取1 m L新鮮尿液作為標本,使用化學顯色法對標本進行巰基化合物含量檢測,并以宮頸活檢的組織病理學為金標準,評價尿液中巰基含量檢測在子宮頸癌篩查中的臨床價值。結(jié)果 在研究組中陽性反應有98例,陽性率為91.6%;健康對照組中人員無陽性反應;陰道炎患者陽性反應有5例,陽性率為25%;HPV感染者陽性反應有12例,陽性率為60%;研究組與健康對照組之間尿液巰基檢測陽性率差異有統(tǒng)計學意義(P0.01)。結(jié)論 尿液中巰基化合物檢測對子宮頸癌及癌前病變篩查具有較高的敏感度,該方法簡便、快速,適用于子宮頸癌的早期篩查。
[Abstract]:Objective to investigate the feasibility of urine thiol compound detection as an early screening method for cervical cancer. Methods 144 cases of urine were collected as control group, including 104 normal subjects, 20 patients with vaginitis and 20 patients with human papillomavirus (HPV) infection. Urine samples from 107 patients with cervical cancer and other gynecologic tumors were used as the study group. Using 1 mL fresh urine as a specimen, the content of sulfhydryl compounds was detected by chemical colorimetry, and the clinical value of the detection of thiol in urine in cervical cancer screening was evaluated with the histopathology of cervical biopsy as the gold standard. Results in the study group, 98 cases were positive, the positive rate was 91.6; in the healthy control group, there was no positive reaction; in vaginitis, there were 5 cases of positive reaction, and the positive rate was 25 cases of HPV infection in 12 cases. The positive rate was 60. There was significant difference between the study group and the healthy control group (P0.01). Conclusion the detection of sulfhydryl compounds in urine is sensitive to the screening of cervical cancer and precancerous lesions. This method is simple, rapid and suitable for early screening of cervical cancer.
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本文編號：2293894