體外心臟震波治療頑固性心絞痛的有效性和安全性
發(fā)布時(shí)間：2018-10-16 14:52
【摘要】：目的探討體外心臟震波治療(CSWT)頑固性心絞痛的有效性和安全性。方法隨機(jī)入選頑固性心絞痛患者45例,按4∶1的比例隨機(jī)分成治療組(36例)和對(duì)照組(9例)。治療前經(jīng)心肌灌注顯像(靜息+運(yùn)動(dòng)負(fù)荷)檢查明確存在可逆性心肌缺血節(jié)段,并定位為治療節(jié)段。以12周為1個(gè)療程,第1、5、9周的周一、周三、周五應(yīng)用震波治療儀對(duì)患者行CSWT,治療組給予能量0.09mJ/mm~2,對(duì)照組不予震波能量。比較患者治療前后的加拿大心血管病學(xué)會(huì)(CCS)心絞痛分級(jí)、西雅圖心絞痛量表(SAQ)評(píng)分、6min步行距離(6MWT)和每周硝酸甘油使用次數(shù),并記錄治療期間的不良事件發(fā)生情況。結(jié)果與治療前比較,治療組治療后的CCS心絞痛分級(jí)顯著降低(P0.05),每周硝酸甘油使用次數(shù)顯著減少(P0.05),SAQ評(píng)分、6MWT均顯著增加(P值均0.05)。對(duì)照組治療前后CCS心絞痛分級(jí)、SAQ評(píng)分、6MWT和每周硝酸甘油使用次數(shù)的差異均無(wú)統(tǒng)計(jì)學(xué)意義(P值均0.05)。所有患者均完成9次CSWT,無(wú)不良事件和不良反應(yīng)發(fā)生。結(jié)論 CSWT作為一種無(wú)創(chuàng)的治療方案,可以有效改善頑固性心絞痛患者的心絞痛發(fā)作頻率和運(yùn)動(dòng)耐量,提高患者的生活質(zhì)量。
[Abstract]:Objective to investigate the efficacy and safety of extracorporeal shock wave in the treatment of (CSWT) intractable angina pectoris. Methods Forty-five patients with refractory angina pectoris were randomly divided into treatment group (n = 36) and control group (n = 9). Myocardial perfusion imaging (resting exercise load) before treatment confirmed the presence of reversible myocardial ischemia and was defined as the therapeutic segment. Take 12 weeks as a course of treatment, Monday, Wednesday, Friday of the first five weeks and nine weeks. The CSWT, treatment group was given energy of 0.09mJ / mmm-2, while the control group was not treated with shock wave energy. (CCS) angina pectoris grade, (SAQ) score of Seattle angina scale, 6min walking distance (6MWT) and times of nitroglycerin use per week were compared before and after treatment, and adverse events were recorded. Results compared with before treatment, the CCS angina pectoris grade of the treatment group decreased significantly (P0.05), and the times of nitroglycerin use per week significantly decreased (P0.05), SAQ score, 6MWT significantly increased (P 0.05). There was no significant difference in CCS angina pectoris grade, SAQ score, 6MWT and weekly nitroglycerin use times before and after treatment in the control group (P < 0. 05). All patients completed 9 CSWT, without adverse events and adverse reactions. Conclusion as a noninvasive treatment regimen, CSWT can effectively improve the frequency of angina pectoris attack and exercise tolerance, and improve the quality of life of patients with refractory angina pectoris.
【作者單位】： 同濟(jì)大學(xué)附屬第十人民醫(yī)院心內(nèi)科;
【基金】：上海申康醫(yī)院發(fā)展中心新興前沿資助項(xiàng)目(03.01.15.002)
【分類號(hào)】：R541.4
，
本文編號(hào)：2274707
[Abstract]:Objective to investigate the efficacy and safety of extracorporeal shock wave in the treatment of (CSWT) intractable angina pectoris. Methods Forty-five patients with refractory angina pectoris were randomly divided into treatment group (n = 36) and control group (n = 9). Myocardial perfusion imaging (resting exercise load) before treatment confirmed the presence of reversible myocardial ischemia and was defined as the therapeutic segment. Take 12 weeks as a course of treatment, Monday, Wednesday, Friday of the first five weeks and nine weeks. The CSWT, treatment group was given energy of 0.09mJ / mmm-2, while the control group was not treated with shock wave energy. (CCS) angina pectoris grade, (SAQ) score of Seattle angina scale, 6min walking distance (6MWT) and times of nitroglycerin use per week were compared before and after treatment, and adverse events were recorded. Results compared with before treatment, the CCS angina pectoris grade of the treatment group decreased significantly (P0.05), and the times of nitroglycerin use per week significantly decreased (P0.05), SAQ score, 6MWT significantly increased (P 0.05). There was no significant difference in CCS angina pectoris grade, SAQ score, 6MWT and weekly nitroglycerin use times before and after treatment in the control group (P < 0. 05). All patients completed 9 CSWT, without adverse events and adverse reactions. Conclusion as a noninvasive treatment regimen, CSWT can effectively improve the frequency of angina pectoris attack and exercise tolerance, and improve the quality of life of patients with refractory angina pectoris.
【作者單位】： 同濟(jì)大學(xué)附屬第十人民醫(yī)院心內(nèi)科;
【基金】：上海申康醫(yī)院發(fā)展中心新興前沿資助項(xiàng)目(03.01.15.002)
【分類號(hào)】：R541.4
，
本文編號(hào)：2274707
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