本文選題：血紅素 + 紅細(xì)胞��； 參考：《中國科學(xué):生命科學(xué)》2017年12期

【摘要】：血紅素不但能作為血紅素蛋白的重要輔基參與細(xì)胞電子傳遞、送氧、酶作用等重要生理活動,而且是紅細(xì)胞穩(wěn)態(tài)及分化的關(guān)鍵調(diào)控者.本綜述主要從3個方面小結(jié)了紅細(xì)胞中血紅素的研究進展.首先,在血紅素生物合成方面,介紹了血紅素生物合成過程、其起始及中間產(chǎn)物的跨膜運輸及調(diào)控機制的研究現(xiàn)狀.其次,重點闡述了血紅素作為紅細(xì)胞穩(wěn)態(tài)及分化的調(diào)控者對紅系特異基因的轉(zhuǎn)錄調(diào)控、mRNA穩(wěn)定性及翻譯、蛋白穩(wěn)定性、miRNA加工合成等過程的調(diào)控機制.最后,簡單總結(jié)了血紅素的合成異常導(dǎo)致的疾病及可能的治療策略.總之,紅細(xì)胞穩(wěn)態(tài)的維持需要協(xié)調(diào)平衡血紅素合成,蛋白(尤其是珠蛋白)產(chǎn)生以及鐵代謝等生物過程,對它們調(diào)控關(guān)系的闡明有助于深入了解紅細(xì)胞分化的調(diào)控機制,同時也對紅細(xì)胞相關(guān)疾病的研究及治療有指導(dǎo)意義.
[Abstract]:Heme can not only play an important role in the electron transfer, oxygen delivery and enzyme activity of heme protein, but also the key regulator of the homeostasis and differentiation of red cells. This review summarizes the development of heme in red cells from 3 aspects. First, heme is introduced in heme biosynthesis. Biosynthesis process, the research status of the transmembrane transport and regulation mechanism of its initiation and intermediate products. Secondly, the regulation mechanism of heme as a regulator of erythrocyte homeostasis and differentiation to the transcription of erythroid specific genes, mRNA stability and translation, protein stability, and miRNA processing and synthesis are introduced. Finally, a brief summary is made. In conclusion, the maintenance of erythrocyte homeostasis needs to coordinate the biosynthesis of heme, protein (especially globin) production and iron metabolism, and the clarifying of their regulatory relationships helps to deepen the regulation of erythrocyte differentiation, as well as red cells. The research and treatment of related diseases have guiding significance.
【作者單位】： 中國醫(yī)學(xué)科學(xué)院&北京協(xié)和醫(yī)學(xué)院血液病醫(yī)院(血液學(xué)研究所)實驗血液學(xué)國家重點實驗室;
【基金】：天津市應(yīng)用基礎(chǔ)面上項目(批準(zhǔn)號:15JCYBJC54500) 中國醫(yī)學(xué)科學(xué)院醫(yī)學(xué)與健康科技創(chuàng)新工程項目(批準(zhǔn)號:2016-12M-1-018,2016-I2M-3-002) 國家自然科學(xué)基金(批準(zhǔn)號:31471291,81700105)資助
【分類號】：R55
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本文編號：2111459