本文選題：q.位點(diǎn) + 單核苷酸多態(tài)性　； 參考：《中國(guó)老年學(xué)雜志》2017年12期

【摘要】：目的探討21q22.11位點(diǎn)與中國(guó)廣東地區(qū)漢族人群冠心病遺傳易感性的相關(guān)性。方法采用病例對(duì)照研究方法,初篩人群包括887例冠心病患者和787例對(duì)照者,驗(yàn)證人群包括698例冠心病患者和759例對(duì)照者,均來(lái)自2012年9月至2013年12月廣東醫(yī)學(xué)院附屬醫(yī)院心內(nèi)科住院患者及同期健康體檢者,采用直接測(cè)序的方法,對(duì)21q22.11位點(diǎn)所選的標(biāo)簽單核苷酸多態(tài)性(SNPs)rs9982601、rs7282240、rs1107763、rs1114333、rs8129269、rs12627487位點(diǎn)進(jìn)行分型,采用非條件邏輯回歸分析統(tǒng)計(jì)21q22.11位點(diǎn)與中國(guó)廣東地區(qū)漢族人群冠心病的相關(guān)性。結(jié)果21q22.11位點(diǎn)標(biāo)簽SNP rs9982601在初篩人群中無(wú)多態(tài)性;標(biāo)簽SNPs rs7282240、rs1107763、rs1114333、rs8129269的等位基因頻率分布在初篩人群中冠心病組與對(duì)照組差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05);rs12627487在初篩人群中冠心病組與對(duì)照組的等位基因頻率差異有統(tǒng)計(jì)學(xué)意義[P(Logistic)=0.043],隨后驗(yàn)證SNP rs12627487,該SNPs在驗(yàn)證人群冠心病組及對(duì)照組中等位基因頻率差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。合并人群后rs12627487在冠心病組及對(duì)照組中等位基因頻率差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05);進(jìn)一步對(duì)年齡、體重指數(shù)(BMI)、吸煙、高血壓、糖尿病及高脂血癥進(jìn)行分層分析仍無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論 21q22.11位點(diǎn)標(biāo)簽SNPs rs9982601、rs7282240、rs1107763、rs1114333、rs8129269、rs12627487位點(diǎn)多態(tài)性與中國(guó)廣東地區(qū)漢族人群冠心病發(fā)病無(wú)明顯相關(guān)。
[Abstract]:Objective to investigate the relationship between 21q22.11 locus and genetic susceptibility to coronary heart disease (CHD) in Chinese Han population. Methods A case-control study was conducted. The primary screening population consisted of 887 patients with coronary heart disease and 787 controls. The validated population included 698 patients with coronary heart disease and 759 controls. From September 2012 to December 2013, all inpatients in Department of Cardiology, affiliated Hospital of Guangdong Medical College, and health examiners were divided into two groups. The single nucleotide polymorphisms rs9982601, rs7102240, rs1114333rs11129269rs12627487 were identified by direct sequencing. Non-conditional logistic regression analysis was used to analyze the correlation between 21q22.11 locus and coronary heart disease (CHD) in Chinese Han population. Results the 21q22.11 locus label SNP rs9982601 was not polymorphic in the primary screening population. The allele frequency of the label SNPs rs7282240 rs1107763rs1114333rs8129269 was not significantly different between the CHD group and the control group in the primary screening population. There was significant difference in allele frequency between the CHD group and the control group in the primary screening group [P(Logistic)=0.043]. SNP rs12627487. There was no significant difference in allele frequency between CHD group and control group (P 0.05). There was no significant difference in allele frequency of rs12627487 between CHD group and control group (P 0.05), and there was no significant difference in age, body mass index (BMI), smoking, hypertension, diabetes mellitus and hyperlipidemia (P 0.05). Conclusion the polymorphism of SNPs rs9982601rs7282240rs1107763rs1114333rs8129269rs12627487 has no significant correlation with the incidence of coronary heart disease in the Han nationality population in Guangdong, China.
【作者單位】： 新鄉(xiāng)市中心醫(yī)院心血管內(nèi)科;廣東醫(yī)科大學(xué)附屬醫(yī)院心血管內(nèi)科;
【基金】：廣東省自然科學(xué)基金(S2013010015074)
【分類(lèi)號(hào)】：R541.4
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本文編號(hào)：1991521