本文選題：冠心病 + 巨噬細胞集落刺激因子��； 參考：《中國老年學(xué)雜志》2017年04期

【摘要】：目的檢測冠心病患者血清巨噬細胞集落刺激因子(M-CSF)、缺氧誘導(dǎo)因子(HIF)-1α,并與冠狀動脈斑塊形態(tài)特征對比分析,探討血清M-CSF、HIF-1α與冠狀動脈不穩(wěn)定斑塊的關(guān)系。方法選擇85例診斷明確的冠心病患者,分為不穩(wěn)定型心絞痛組(UAP組)30例、非ST段抬高心肌梗死組(NSTEMI組)25例以及穩(wěn)定型心絞痛(SAP組)30例。所有患者通過冠狀動脈造影檢查,并按Ambrose分型分為Ⅰ~Ⅲ型,用酶聯(lián)免疫法測定血清M-CSF、HIF-1α水平。結(jié)果①NSTEMI組和UAP組血清M-CSF、HIF-1α水平均顯著高于SAP組。②NSTEMI組中斑塊形態(tài)以Ambrose斑塊分型Ⅱ、Ⅲ型為主,UAP組以Ⅰ、Ⅱ型為主,SAP組以Ambrose斑塊形態(tài)分型Ⅰ型為主;③血清M-CSF、HIF-1α水平隨斑塊的不穩(wěn)定性增加逐漸升高,即Ⅲ型Ⅱ型Ⅰ型。④直線相關(guān)分析顯示:在各組中M-CSF和HIF-1α正相關(guān)(P0.01)。結(jié)論血清M-CSF和HIF-1α與冠狀動脈斑塊的不穩(wěn)定性有關(guān),聯(lián)合檢測血清M-CSF和HIF-1α水平對評估病情、指導(dǎo)治療、評價療效有一定參考價值。
[Abstract]:Objective to investigate the relationship between serum macrophage colony stimulating factor (M-CSF-1), hypoxia inducible factor (HIF-1 偽) and coronary plaque morphology in patients with coronary heart disease (CHD). Methods Eighty-five patients with coronary heart disease were divided into three groups: UAP group (n = 30), NSTEMI group (n = 25) and stable angina pectoris group (n = 30). All patients were examined by coronary arteriography and divided into type 鈪，

本文編號：1775430