本文選題：黃芪 + 地西他濱��； 參考：《中國臨床藥理學(xué)雜志》2017年21期

【摘要】：目的觀察黃芪注射液聯(lián)合地西他濱注射液在治療骨髓增生異常綜合征(MDS)上的臨床療效及安全性。方法將67例MDS患者按入院先后分為試驗(yàn)組38例和對照組29例。對照組予以靜脈滴注25 mg·m~(-2)地西他濱注射液,每個療程開始后第1~5 d進(jìn)行滴注治療,每日滴注時(shí)間為1 h,以4周為1個療程,連續(xù)治療4個療程。試驗(yàn)組在對照組的基礎(chǔ)上靜脈滴注黃芪注射液30 mL。比較2組患者的臨床療效、白細(xì)胞計(jì)數(shù)、血小板計(jì)數(shù)、白細(xì)胞分化抗原34(CD34)和CD117水平以及藥物不良反應(yīng)的發(fā)生情況。結(jié)果治療后,試驗(yàn)組和對照組的總有效率分別為65.79%(25例/38例)和41.38%(12例/29例),差異有統(tǒng)計(jì)學(xué)意義(P0.05)。治療后,試驗(yàn)組和對照組的白細(xì)胞計(jì)數(shù)分別為(2.82±0.42)×10~9/L、(2.31±0.26)×10~9/L,血小板計(jì)數(shù)分別為(92.51±17.09)×10~9/L,(82.01±10.07)×10~9/L,CD34表達(dá)率分別為(7.91±1.88)%,(9.13±2.54)%,CD117表達(dá)率分別為(9.02±1.63)%,(10.01±1.53)%,差異均有統(tǒng)計(jì)學(xué)意義(均P0.05)。試驗(yàn)組和對照組的中位生存期分別為(32.29±9.00),(27.17±10.53)月,中位無進(jìn)展生存期分別為(22.91±6.61),(21.26±10.02)月,差異均有統(tǒng)計(jì)學(xué)意義(均P0.05)。試驗(yàn)組發(fā)生惡心嘔吐5例,發(fā)熱3例;對照組發(fā)生惡心嘔吐6例,發(fā)熱5例,感染1例,肝腎損傷1例,試驗(yàn)組和對照組的藥物不良反應(yīng)發(fā)生率分別為21.05%(8例/38例)和44.83%(13例/29例),差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論黃芪注射液聯(lián)合地西他濱注射液能夠有效促進(jìn)髓系細(xì)胞的成熟和分化,臨床療效顯著,安全性高。
[Abstract]:Objective To observe the effect of Huangqi injection combined with decitabine injection in the treatment of myelodysplastic syndrome (MDS) clinical curative effect and safety. Methods 67 cases of MDS patients were divided into test group of 38 cases and 29 cases in the control group. The control group received intravenous infusion of 25 mg - m~ (-2) to the West capecitabine injection, the beginning of each course 1~5 after D infusion therapy, daily infusion time was 1 h, with 4 weeks for 1 courses, 4 courses of continuous treatment. Compared the experimental group in the control group on the basis of intravenous infusion of Huangqi Injection 30 mL. the clinical efficacy of the 2 groups, white blood cell count platelet count, leukocyte differentiation antigen 34 (CD34) and CD117 levels and adverse drug reactions. Results after treatment, the test group and the control group the total effective rate was 65.79% (25 /38 cases) and 41.38% (12 /29 cases), the difference was statistically significant (P0.05) after treatment. The test group. 鍜屽鐓х粍鐨勭櫧緇嗚優(yōu)璁℃暟鍒嗗埆涓，

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