本文選題：冠心病　切入點(diǎn)：經(jīng)皮冠狀動脈腔內(nèi)血管成形術(shù)　出處：《中國老年學(xué)雜志》2017年10期 　論文類型：期刊論文

【摘要】：目的探討老年冠心病經(jīng)皮冠狀動脈腔內(nèi)血管成形術(shù)(PTCA)術(shù)后支架內(nèi)再狹窄(ISR)患者血漿干擾素誘導(dǎo)蛋白(IP)-10水平表達(dá)及其相關(guān)危險因素。方法 90例老年冠心病患者均接受PTCA手術(shù)治療,并植入冠狀動脈支架,術(shù)后6個月行冠狀動脈造影(CAG)復(fù)查。根據(jù)復(fù)查結(jié)果,分為ISR組28例,支架內(nèi)無再狹窄組32例,另30例CAG結(jié)果顯示冠狀動脈狹窄程度50%為對照組。詳細(xì)記錄3組臨床資料,并對血漿IP-10濃度進(jìn)行測定,分析ISR發(fā)生相關(guān)危險因素。結(jié)果 ISR組血漿IP-10濃度高于支架內(nèi)無再狹窄組及對照組(P0.05);支架內(nèi)無再狹窄組高于對照組(P0.05);Logistic回歸分析結(jié)果顯示,吸煙史、支架長度、糖尿病史、血清尿酸、血清總膽紅素及血漿IP-10表達(dá)水平與ISR發(fā)生存在相關(guān)性(P0.05),是ISR發(fā)生高危因素。結(jié)論老年冠心病患者經(jīng)PTCA治療后,IP-10水平表達(dá)較高可作為臨床診斷冠心病術(shù)后ISR的生化指標(biāo)之一;吸煙史、支架長度、糖尿病史、血清尿酸、血清總膽紅素是術(shù)后ISR發(fā)生高危因素,對具備這些高危因素的患者應(yīng)強(qiáng)化藥物治療,及早控制。
[Abstract]:Objective to investigate the expression and risk factors of plasma interferon inducible protein (IFN) -10 in elderly patients with coronary artery disease (CHD) after percutaneous transluminal coronary angioplasty (PTCA) and restenosis in stents. Methods 90 elderly patients with coronary heart disease were enrolled in this study. Undergoing PTCA surgery, Coronary stents were implanted and coronary angiography was performed 6 months after operation. According to the results, 28 patients were divided into ISR group and 32 patients without restenosis in the stents. The results of CAG in 30 cases showed that the coronary artery stenosis degree was 50% as the control group. The clinical data of the three groups were recorded in detail, and the plasma IP-10 concentration was measured. Results the plasma IP-10 concentration in ISR group was higher than that in non-restenosis group and control group (P 0.05), and the logistic regression analysis showed that smoking history, stent length and diabetes history were higher in ISR group than those in control group. Serum uric acid, Serum total bilirubin and plasma IP-10 expression were correlated with the occurrence of ISR, which was a high risk factor for the occurrence of ISR. Conclusion the high expression of IP-10 in elderly patients with coronary heart disease after PTCA treatment can be used as one of the biochemical indexes for clinical diagnosis of ISR after coronary heart disease surgery. Smoking history, stent length, diabetes history, serum uric acid and serum total bilirubin were high risk factors for postoperative ISR.
【作者單位】： 濰坊市人民醫(yī)院心內(nèi)二科;
【基金】：濰坊市科技局資助項(xiàng)目(No.201302002)
【分類號】：R541.4

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