本文選題：2型糖尿病　切入點(diǎn)：高血壓　出處：《廣西醫(yī)科大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

【摘要】：目的:探討2型糖尿病合并高血壓患者同型半胱氨酸水平的變化及其可能的原因。方法:以2016年1月至2016年12月在我院住院的2型糖尿病合并高血壓患者85例為糖尿病并高血壓組,無高血壓的2型糖尿病患者73例為單純糖尿病組,同期體檢中心健康體檢者32例為正常對照組。所有入選對象均符合診斷標(biāo)準(zhǔn)與排除標(biāo)準(zhǔn)。收集所有研究對象的臨床資料,測定其一般生化指標(biāo),并測定血清同型半胱氨酸(Hcy)、葉酸、維生素B12(VitB12)、空腹胰島素(FINS)水平。再以血清Hcy水平大于等于15μmol/L為界,將糖尿病并高血壓組分為同型半胱氨酸水平升高組(Hcy升高組)和同型半胱氨酸水平正常組(Hcy正常組)。結(jié)果:糖尿病并高血壓組的Hcy水平高于單純糖尿病組及正常對照組,葉酸水平低于單純糖尿病組及正常對照組,差異具有統(tǒng)計學(xué)意義(P0.05)。Hcy升高組的葉酸水平明顯低于Hcy正常組,差異有統(tǒng)計學(xué)意義(P0.05)。相關(guān)分析顯示2型糖尿病合并高血壓患者血清Hcy水平與血肌酐(Cr)、尿素氮(BUN)正相關(guān),與葉酸負(fù)相關(guān),差異均有統(tǒng)計學(xué)意義(P0.05),與年齡、身高、體重、BMI、收縮壓、舒張壓、空腹血糖、餐后2小時血糖、糖化血紅蛋白、ALT、AST、UA、TG、VitB12、HOMA-IR均無線性相關(guān)關(guān)系(P0.05)。結(jié)論:2型糖尿病合并高血壓患者血清Hcy水平升高,這可能是由于葉酸水平降低所致。
[Abstract]:Objective: to investigate the changes of homocysteine level in patients with type 2 diabetes mellitus complicated with hypertension and its possible causes. Methods: from January 2016 to December 2016, 85 patients with type 2 diabetes mellitus complicated with hypertension were enrolled in our hospital. Diabetes with hypertension, Seventy-three patients with type 2 diabetes without hypertension were treated with simple diabetes mellitus, while 32 patients with healthy physical examination in the same period were normal control group. All the subjects were in accordance with the diagnostic criteria and exclusion criteria. The clinical data of all the subjects were collected. The serum levels of homocysteine, folic acid, vitamin B12 and fasting insulin were determined. The serum Hcy level was greater than or equal to 15 渭 mol/L. The patients with diabetes mellitus complicated with hypertension were divided into two groups: hyperhomocysteine (Hcy) and homocysteine (Hcy). Results: the level of Hcy in diabetic patients with hypertension was higher than that in diabetic patients and normal controls. The level of folic acid was lower than that of simple diabetes mellitus group and normal control group, and the level of folic acid in the group with elevated P0.05 + Hcy was significantly lower than that in the normal group of Hcy. The correlation analysis showed that the serum Hcy level was positively correlated with creatinine, bun and folic acid in patients with type 2 diabetes mellitus complicated with hypertension, and negatively correlated with folic acid, and was significantly correlated with age, height, body weight and systolic blood pressure. Diastolic blood pressure, fasting blood glucose, 2 hours postprandial blood glucose, and glycosylated hemoglobin TGVitB12Homa Homa IR had no linear correlation. Conclusion the serum Hcy level in patients with type 2 diabetes mellitus with hypertension is increased, which may be due to the decrease of folic acid level.
【學(xué)位授予單位】：廣西醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R587.1;R544.1

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