本文選題：冠狀動脈　切入點：介入　出處：《廣東醫(yī)學》2017年08期 　論文類型：期刊論文

【摘要】：目的探討復雜冠脈病變介入術后使用那曲肝素抗凝對患者預后的影響。方法選擇接受經皮冠脈介入治療的復雜冠脈病變患者為觀察對象。根據患者術后是否使用那曲肝素分為非抗凝組和抗凝組,每組各50例患者。比較兩組患者經介入治療前后心肌損傷標志物變化、3個月內心血管事件發(fā)生情況和生活質量。結果兩組患者介入治療前心肌肌鈣蛋白T(cTnT)和心肌肌酸激酶同工酶(CK-MB)水平無明顯差別,介入治療后24 h內,兩組患者的上述指標均較手術前有所升高,且非抗凝組升高較抗凝組更明顯(P0.05);兩組患者介入治療后3個月內急性心肌梗死發(fā)生率和出血發(fā)生率無明顯差別,而抗凝組側支閉塞率和病死率明顯低于非抗凝組(P0.05);兩組患者介入治療后總體生活質量差異無統(tǒng)計學意義(P0.05)。結論復雜冠脈病變經介入治療術后使用那曲肝素抗凝可明顯降低側支閉塞和病死率,具有較好的臨床應用價值。
[Abstract]:Objective to investigate the effect of Natrix heparin anticoagulant therapy on the prognosis of patients with complicated coronary artery disease after coronary intervention. Methods patients with complicated coronary artery disease undergoing percutaneous coronary intervention were selected as observation objects. Naqu heparin was divided into non-anticoagulant group and anticoagulant group. The changes of myocardial injury markers, the occurrence of cardiovascular events and the quality of life in three months before and after interventional therapy were compared. Results before and after interventional therapy, cardiac troponin TnTnT) and myocardial muscle were compared between the two groups. There was no significant difference in creatine kinase isoenzyme CK-MBs. Within 24 hours after interventional therapy, the above indexes in both groups were higher than those before operation, and the increase in non-anticoagulant group was more obvious than that in anticoagulant group (P 0.05), and there was no significant difference in the incidence of acute myocardial infarction and bleeding within 3 months after interventional therapy between the two groups. However, the rate of collateral occlusion and mortality in the anticoagulant group were significantly lower than those in the non-anticoagulant group (P 0.05), and there was no significant difference in the overall quality of life between the two groups after interventional therapy. Conclusion after interventional treatment of complex coronary artery disease, Natrix heparin can be used as anticoagulant agent. The side branch occlusion and mortality were significantly reduced. It has good clinical application value.
【作者單位】： 潮州市中心醫(yī)院心血管內科;
【分類號】：R541.4

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