本文關(guān)鍵詞：保和丸加減聯(lián)合鐵劑治療脾胃虛弱型缺鐵性貧血的臨床觀察　出處：《廣州中醫(yī)藥大學》2016年碩士論文　論文類型：學位論文

  更多相關(guān)文章： 保和丸 鐵劑 副作用 脾胃虛弱 缺鐵性貧血

【摘要】：背景：缺鐵性貧血(IDA)是最常見的營養(yǎng)素缺乏癥,各年齡階段均有發(fā)病,其高危人群為婦女、嬰幼兒和兒童。鐵是合成血紅蛋白的必須元素,同時又在生物氧化等過程中起重要作用。鐵元素的缺乏不僅會使血紅蛋白的合成減少,還會影響細胞和組織內(nèi)含鐵酶和鐵依賴酶的活性,進一步則會影響細胞組織代謝、降低機體免疫力及引起其他組織器官的多種表現(xiàn),從而危害人體健康。目前鐵劑治療缺鐵性貧血療效確切。但鐵劑的副作用不可避免的影響了鐵劑的使用,從而使部分缺鐵性貧血患者不能恢復健康,因此尋找有效且能降低鐵劑副作用發(fā)生的治療方法成為目前最常面對的內(nèi)科問題之一。目的：通過保和丸聯(lián)合鐵劑治療脾胃虛弱型缺鐵性貧血,系統(tǒng)分析治療前后臨床癥狀積分、鐵劑副作用發(fā)生率及相關(guān)實驗室檢查變化,了解保和丸加減聯(lián)合鐵劑治療脾胃虛弱型缺鐵性貧血對臨床癥狀及降低鐵劑副作用的情況,并運用中西醫(yī)理論分別闡述脾胃虛弱型缺鐵性貧血患者采用保和丸加減聯(lián)合鐵劑治療降低鐵劑副作用發(fā)生的機理,為其可行性提供理論及實踐基礎(chǔ),為治療缺鐵性貧血尋求更為安全有效的治療方案。方法：將34例合格受試對象隨機分為兩組,試驗組17例,對照組17例,試驗組給予保和丸加減聯(lián)合多糖鐵復合物膠囊(力蜚能),療程30天。對照組給予多糖鐵復合物膠囊(力蜚能),療程30天。觀察兩組治療前后臨床癥狀、血常規(guī)和鐵代謝指標的變化,以及治療中鐵劑副作用的發(fā)生情況。成果：1.按中醫(yī)癥候療效判定標準：兩組治療后中醫(yī)癥狀積分降低,臨床癥狀改善。其中,試驗組總治愈率為41.17%,對照組總治愈率為17.65%,經(jīng)非參數(shù)檢驗差別有統(tǒng)計學意義(PO.05),說明兩組治療方法在中醫(yī)癥候療效上有差別。兩組治療中試驗組鐵劑副作用發(fā)生率較低,經(jīng)Fisher確切概率法檢驗差別有統(tǒng)計學意義(P0.05),說明兩組在降低鐵劑副作用上差異明顯。2.按西醫(yī)療效判定標準：由統(tǒng)計結(jié)果可見,兩組對治療缺鐵性貧血均有顯著療效。其中,試驗組治愈率17.65%,對照組治愈率35.29%,經(jīng)非參數(shù)檢驗差異無統(tǒng)計學意義(P0.05),說明兩組在治療缺鐵性貧血的西醫(yī)臨床療效上無明顯差異。在鐵代謝方面,兩組治療后血清鐵、鐵蛋白、轉(zhuǎn)鐵蛋白飽和度均較治療前升高,經(jīng)配對t檢驗比較,差異有統(tǒng)計學意義(P0.05),說明兩組均能顯著提高患者鐵代謝相關(guān)指標。同時試驗組與對照組治療后鐵代謝方面指標經(jīng)t檢驗比較,差異無統(tǒng)計學意義(PO.05),說明兩組治療缺鐵性貧血在提高鐵代謝相關(guān)指標上無差異。結(jié)論：保和丸加減聯(lián)合鐵劑治療脾胃虛弱型缺鐵性貧血在中醫(yī)癥候療效方面明顯優(yōu)于單純鐵劑治療,并可有效降低鐵劑副作用的發(fā)生。
[Abstract]:Background: iron deficiency anemia (Ida) is the most common nutritional deficiency. It occurs at all ages. The high risk groups are women, infants and children. Iron is the essential element in the synthesis of hemoglobin. Iron deficiency not only reduces the synthesis of hemoglobin, but also affects the activities of ferritin and iron dependent enzymes in cells and tissues. Further, it will affect cell tissue metabolism, reduce the body's immunity and cause a variety of manifestations of other tissues and organs. So as to endanger human health. Iron treatment of iron deficiency anemia is effective. But the side effects of iron inevitably affect the use of iron, so that some iron deficiency anemia patients can not recover their health. Therefore, it is one of the most common medical problems to find an effective and effective way to reduce the side effects of iron. Objective: to treat the iron deficiency anemia of spleen and stomach with Baohe pills combined with iron. The clinical symptom scores, the incidence of iron side effects and the changes of laboratory examination before and after treatment were systematically analyzed. Objective: to understand the clinical symptoms and reduce the side effects of Baohe pills combined with iron in the treatment of iron deficiency anemia of deficiency of spleen and stomach. And using the theory of traditional Chinese and western medicine to explain the spleen and stomach iron deficiency anemia patients with Baohe plus subtraction combined with iron treatment to reduce the occurrence of side effects of iron, to provide a theoretical and practical basis for its feasibility. Methods: 34 eligible subjects were randomly divided into two groups: the experimental group (n = 17) and the control group (n = 17). The experimental group was treated with Baohe pills combined with polysaccharide-iron complex capsule for 30 days, while the control group was given the polysaccharide iron compound capsule for 30 days. The clinical symptoms were observed before and after treatment. Changes in blood routine and iron metabolism indexes, and the occurrence of iron side effects in treatment. Results: 1. According to TCM symptom efficacy criteria: two groups of TCM symptoms after treatment scores decreased, clinical symptoms improved. The total cure rate of the test group was 41.17 and that of the control group was 17.65.The difference was statistically significant by non-parametric test (P < 0.05). Two groups of treatment methods in the treatment of TCM symptoms and efficacy differences. Two groups of treatment in the treatment of iron side effects are lower, by the Fisher exact probability test the difference is statistically significant (P 0.05). According to the criteria of western medicine efficacy: from the statistical results, we can see that the two groups of iron deficiency anemia treatment has a significant effect. Among them. The cure rate was 17.65 in the test group and 35.29 in the control group. There was no significant difference between the two groups by non-parametric test (P0.05). In iron metabolism, the serum iron, ferritin and transferrin saturation in the two groups after treatment were higher than those before treatment, compared with the paired t test. The difference was statistically significant (P 0.05), indicating that the two groups can significantly improve the related indexes of iron metabolism. At the same time, the test group and the control group after treatment of iron metabolism indicators were compared by t test. The difference was not statistically significant (P < 0.05). The results showed that there was no difference between the two groups in the improvement of iron metabolism. Conclusion: Baohe pills combined with iron in the treatment of deficiency of spleen and stomach iron deficiency anemia in the treatment of traditional Chinese medicine symptoms significantly better than simple iron treatment. And can effectively reduce the occurrence of side effects of iron.
【學位授予單位】：廣州中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2016
【分類號】：R556.3

【相似文獻】

相關(guān)期刊論文 前10條

1 于建新;;鐵劑治療對膝、髖關(guān)節(jié)修復患者有好處[J];國外醫(yī)學情報;1995年05期

2 孫榮歸;李素娟;;補鐵治療中應注意的問題[J];解放軍健康;2010年04期

3 張維煌;;鐵劑治療對無貧血的缺鐵嬰兒行為特性的影響[J];國外醫(yī)學.輸血及血液學分冊;1984年02期

4 馬沛然,楊秀英,李歡民,張云霞,孫慶云;維生素E配合鐵劑治療缺鐵性貧血的療效觀察[J];實用兒科雜志;1988年03期

5 周健強;梁健智;;老年人缺鐵性貧血鐵劑治療的療效觀察[J];中國現(xiàn)代醫(yī)生;2009年22期

6 孟凡義;汪月增;劉海川;張安勝;;鐵劑對缺鐵性貧血患者血清鐵蛋白質(zhì)的影響[J];中國人民解放軍軍醫(yī)進修學院學報;1988年03期

7 張學愚;郝世奮;王惠芹;周祖釗;;小劑量鐵劑治療小兒營養(yǎng)性缺鐵性貧血的療效觀察[J];中級醫(yī)刊;1990年07期

8 ;異食癖的治療[J];中國初級衛(wèi)生保健;1988年02期

9 葉芬;姜小飛;;人重組促紅細胞生成素聯(lián)合鐵劑治療慢性心力衰竭合并貧血的療效[J];廣東醫(yī)學;2012年15期

10 M·O·Rothschild;梁鳳閣;;關(guān)于肌肉注射鐵劑治療貧血[J];山東醫(yī)刊;1961年11期

相關(guān)重要報紙文章 前6條

1 尤成功;補鐵“問題”有三[N];醫(yī)藥經(jīng)濟報;2002年

2 宋麗華;合理用藥治療小兒缺鐵性貧血[N];中國中醫(yī)藥報;2007年

3 南京軍區(qū)福州總醫(yī)院 副主任醫(yī)師 王言貴;貧血的病因診斷非常重要[N];家庭醫(yī)生報;2003年

4 呂乃群;貧血補鐵還要補維生素A[N];家庭醫(yī)生報;2006年

5 湖南 劉家清;科學飲食防貧血[N];家庭醫(yī)生報;2004年

6 丁山;維生素A有助于治療貧血[N];中國醫(yī)藥報;2002年

相關(guān)碩士學位論文 前2條

1 富霞;保和丸加減聯(lián)合鐵劑治療脾胃虛弱型缺鐵性貧血的臨床觀察[D];廣州中醫(yī)藥大學;2016年

2 溫曉瑩;健脾益氣補血法聯(lián)合小劑量鐵劑治療缺鐵性貧血的臨床研究[D];廣州中醫(yī)藥大學;2013年

，

本文編號：1384649