【摘要】：目的觀察便秘小鼠結(jié)腸肌的電生理變化。方法用復(fù)方地芬諾酯混懸液對小鼠進行灌胃建立便秘模型,然后測定其小腸結(jié)腸段的肌電,并分析其電生理活動變化。結(jié)果與對照組比較,便秘組慢波肌電頻率明顯增快(P0.01);結(jié)腸肌電慢波頻率的變異系數(shù)明顯增大(P0.01);結(jié)腸肌電慢波振幅明顯減少(P0.01);結(jié)腸肌電慢波振幅變異系數(shù)明顯增大(P0.01)。結(jié)論便秘小鼠結(jié)腸肌電慢波頻率及振幅的異常改變可能是導(dǎo)致結(jié)腸傳輸減慢的重要原因。
[Abstract]:Objective to observe the electrophysiological changes of colonic muscle in constipation mice. Methods the constipation model of mice was established by oral administration of compound diphenoxylate suspension, then the myoelectric activity of colon segment of small intestine was measured, and the changes of electrophysiological activities were analyzed. Results compared with the control group, the frequency of slow wave myoelectric wave in constipation group increased significantly (P0.01), the coefficient of variation of slow wave frequency of colonic myography increased significantly (P0.01), the amplitude of slow wave of colonic electromyography decreased significantly (P0.01). The coefficient of variation of slow wave amplitude of colonic electromyography was significantly increased (P 0.01). Conclusion the abnormal changes of frequency and amplitude of colonic myoelectric slow wave in constipation mice may be the important cause of slow colonic transmission.
【作者單位】： 鄭州大學(xué)第一附屬醫(yī)院神經(jīng)內(nèi)科;新鄉(xiāng)醫(yī)學(xué)院生理學(xué)與神經(jīng)生物學(xué)教研室中英腦功能損傷聯(lián)合實驗室河南省高校腦研究重點實驗室培育基地;新鄉(xiāng)醫(yī)學(xué)院第三附屬醫(yī)院營養(yǎng)科;新鄉(xiāng)醫(yī)學(xué)院第二附屬醫(yī)院河南省生物精神病學(xué)重點實驗室;
【基金】：河南省教育廳課題(15A310006) 河南省衛(wèi)生科技創(chuàng)新型人才工程專項經(jīng)費(3052) 國家級大學(xué)生創(chuàng)新創(chuàng)業(yè)訓(xùn)練計劃項目(201610472013) 河南省高�？萍紕�(chuàng)新團隊(17IRTSTHN023)
【分類號】：R574.62

【參考文獻】

相關(guān)期刊論文 前4條

1 王佩佩;羅雯;禹錚;李明瑋;;慢性便秘的研究進展[J];中國全科醫(yī)學(xué);2017年03期

2 羅敷;王q邛，

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