本文關鍵詞：慢性乙型肝炎疾病進展中瞬時彈性波檢測的意義及其影響因素，由筆耕文化傳播整理發(fā)布。

慢性乙型肝炎疾病進展中瞬時彈性波檢測的意義及其影響因素

Significance and influential factors of Fibroscan detection in the progress of patients with chronic hepatitis B disease

[1] [2] [3] [4] [5]

LIU Wei, DING Ai-kun , LI Cheng , SHAN Rong , WANG Chang-yuan （1. School of Medicine, Shandong University, Jinan 250012, China; 2. Seventh Depatment of Jinan Infectious

[1]山東大學醫(yī)學院,濟南250012; [2]濟南市傳染病醫(yī)院七科,濟南250021; [3]濟南市傳染病醫(yī)院超聲診斷科,濟南250021

文章摘要：目的探討瞬時彈性波檢測（Fibroscan，F(xiàn)S）對慢性乙型肝炎患者疾病進展的評價作用及影響因素。方法收集660例FS檢測的慢性乙型肝炎患者臨床資料和其中96進行肝組織活檢的病理結果，分析各臨床指標對FS值（硬度值）的影響。根據(jù)肝臟病理纖維化分期進行分類，繪制不同纖維化分期FS值的受試者工作特征曲線（ROC），計算曲線下面積（AUC）。結果不同性別、年齡、PLT、PTA、ALT、TBIL、ALB、門脈內徑和脾臟厚度水平的FS值有差異（P〈0．05）。多元線性逐步回歸分析顯示，ALT、PTA、ALB、脾臟厚度、門靜脈內徑、PLT、TBIL與FS值相關，其對FS值的影響依次減弱。肝纖維化輕度（S1）18例、中度（S2）39例、重度（s3）12例和肝硬化（S4）27例的AUC分別為0．724、0．832、0．836和0．798，診斷的界值分別為9．8、10．5、12．3和14．8kPa。結論FS與肝臟病理纖維化分期符合率高，是評估慢性乙型肝炎疾病進展有價值的無創(chuàng)檢查方法。

Abstr：Objective To explore the evaluation effect and analyze the influential factors of Fibroscan （FS） detection in the progress of patients with chronic hepatitis B disease. Methods Six hundred and sixty patients with chronic hepatitis B disease were detected with Fibroscan and their clinical data were collected, and 96 of them had liver biopsy results. Influences of various clinical indicators on FS values were analyzed. The 96 cases were grouped based on their fibrosis stage in biopsy, the receiver-operating characteristic curves （ROC） of FS values were drawn and the areas under the curve （AUC） were calculated. Results Multiple clinical indexes, such as age, gender, PLT, PTA, ALT, TBIL, the inner diameter of portal vein and thickness of spleen were associated with FS value, and their differences between differ- ent levels had statistical significance（P 〈0.05）. Multiple linear stepwise regression analysis showed that ALT, PTA, thickness of spleen, the inner diameter of portal vein, PLT and TBIL were correlated with FS value. According to the absolute value of the standard regression coefficient, the influence of these indicators on FS value decreased gradually. The AUCs of FS detection for 18 cases of mild （ S1 ）, 39 cases of moderate （ $2）, 12 cases of severe （$3） degree liver fibrosis and 27 cases of cirrhosis （$4） were 0.724, 0.832, 0.836 and 0.798, respectively, and the cut-off values for diagnosis of various degree of fibrosis and cirrhosis were 9.8, 10.5, 12.3 and 14.8 kPa, respectively. Contusion Fibroscan detection has a high coincidence rate with liver pathological fibrosis stage. It is a very effective and noninva- sive examination in assessing disease progression of patients with chronic hepati

文章關鍵詞：

Keyword：:Fibroscan Liver fibrosis Liver stiffness Chronic hepatitis B Liver cirrhosis

作者信息：會員可見

  本文關鍵詞：慢性乙型肝炎疾病進展中瞬時彈性波檢測的意義及其影響因素，由筆耕文化傳播整理發(fā)布。