【摘要】：目的:分析非酒精性脂肪肝病(non-alcoholic fatty liver disease,NAFLD)中長鏈非編碼RNA(lncRNA)的表達譜特征。方法:采用lncRNA-m RNA基因芯片檢測單純性膽囊結石伴或不伴NAFLD患者的肝組織樣本,獲得lncRNA差異性表達譜。進一步使用生物信息學技術對差異表達的基因予以分析。結果:與正常樣本相比,NAFLD肝樣本內共有1 735個lncRNAs和1 485個mRNAs異常表達,其中535個lncRNAs和760個mRNAs上調,1 200個lncRNAs和725個mRNAs下調。結論:與正常肝組織相比,NAFLD組織中l(wèi)ncRNA表達譜明顯異常,這些lncRNAs可能在NAFLD的發(fā)生和發(fā)展中發(fā)揮重要作用。
[Abstract]:Objective: to analyze the characteristics of long chain non-coding RNA (lncRNA) expression in non-alcoholic fatty liver disease (non-alcoholic fatty liver disease,NAFLD). Methods: lncRNA-m RNA gene chip was used to detect the liver tissue samples of patients with or without NAFLD in simple gallstone, and the differential expression profile of lncRNA was obtained. Further use of bioinformatics to analyze differentially expressed genes. Results: there were 1 735 lncRNAs and 1 485 mRNAs abnormal expression in NAFLD liver samples, 535 lncRNAs and 760 mRNAs up-regulated, 1 200 lncRNAs and 725 mRNAs down-regulated. Conclusion: compared with normal liver tissues, lncRNA expression profiles in NAFLD tissues are significantly abnormal, and these lncRNAs may play an important role in the occurrence and development of NAFLD.
【作者單位】： 中南大學湘雅三醫(yī)院急診科;中南大學湘雅三醫(yī)院肝膽外科;中南大學湘雅三醫(yī)院康復科;
【基金】：國家自然科學基金(81600461)~~
【分類號】：R575.5

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本文編號：2285268