本文選題：肝腫瘤 + 髓系來源性抑制細(xì)胞��； 參考：《實(shí)用醫(yī)學(xué)雜志》2017年13期

【摘要】：目的研究髓系來源性抑制細(xì)胞(MDSCs)在乙肝感染相關(guān)性肝癌患者外周血中的表達(dá)及意義。方法選擇我院收治的50例肝癌患者、34例慢性乙肝患者和23例健康體檢者,流式檢測外周血單個(gè)核細(xì)胞中MDSCs及其亞型的比例,分析MDSCs與肝癌病理特征的關(guān)系以及與相關(guān)生化指標(biāo)之間的相關(guān)關(guān)系。結(jié)果乙肝感染相關(guān)性肝癌患者外周血中MDSCs比例中位數(shù)為2.60%,明顯高于健康對照組(0.70%)和慢性乙肝組(1.45%),差異均有統(tǒng)計(jì)學(xué)意義(P0.01);肝癌組患者中,MDSCs兩種亞型g MDSCs和m MDSCs比例均比健康對照組升高(P0.05),在慢性乙肝組和健康對照組患者之間無明顯差異(P0.05);MDSCs比例與肝癌病理特征及肝功能相關(guān)生化指標(biāo)等均無相關(guān)關(guān)系(P0.05)。結(jié)論 MDSCs及其亞型可在HBV相關(guān)性肝癌患者外周血中升高,可作為乙肝相關(guān)性肝癌的臨床監(jiān)測指標(biāo)。
[Abstract]:Objective to study the expression and significance of myeloid derived inhibitory cells (MDSCs) in peripheral blood of patients with hepatitis B infection associated hepatocellular carcinoma (HCC). Methods the proportion of MDSCs and their subtypes in peripheral blood mononuclear cells (PBMC) was detected by flow cytometry in 34 patients with chronic hepatitis B and 23 healthy controls. To analyze the relationship between MDSCs and pathological features of liver cancer and the correlation between MDSCs and biochemical indexes. Results the median proportion of MDSCs in peripheral blood of patients with hepatitis B infection associated hepatocellular carcinoma was 2.60, which was significantly higher than that of healthy control group (0.70%) and chronic hepatitis B group (1.45%), the difference was statistically significant (P0.01), and the proportion of two subtypes of MDSCs g MDSCs and m MDSCs in liver cancer patients was significantly higher than that in healthy control group (0.70%) and chronic hepatitis B group (1.45%). There was no significant difference between chronic hepatitis B group and healthy control group (P0.05) the proportion of MDSCs had no correlation with liver cancer pathological characteristics and liver function related biochemical index (P0.05). Conclusion MDSCs and their subtypes can increase in the peripheral blood of patients with HBV-associated liver cancer and can be used as a clinical monitoring index for HBV-associated liver cancer.
【作者單位】： 廣州醫(yī)科大學(xué)附屬第二醫(yī)院檢驗(yàn)科;
【分類號】：R512.62;R735.7

【參考文獻(xiàn)】

相關(guān)期刊論文 前1條

1 儲(chǔ)眉;唐文;周媛;蘇宇雄;廖貴清;;全反式維甲酸減少舌癌小鼠髓樣來源抑制細(xì)胞[J];實(shí)用醫(yī)學(xué)雜志;2016年02期

【共引文獻(xiàn)】

相關(guān)期刊論文 前1條

1 朱雪蓮;鄧小燕;吳曉蔓;;髓系來源性抑制細(xì)胞在HBV感染相關(guān)性肝癌中的表達(dá)及意義[J];實(shí)用醫(yī)學(xué)雜志;2017年13期

【二級參考文獻(xiàn)】

相關(guān)期刊論文 前2條

1 鄭相淮;趙建江;賈搏;盤杰;陳軍;邱小玲;韓久松;y嚭樾，

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