本文選題：超聲射頻時(shí)間序列　切入點(diǎn)：相對偏差評分法　出處：《生物醫(yī)學(xué)工程學(xué)雜志》2015年01期

【摘要】：提出了基于超聲射頻(RF)時(shí)間序列的肝纖維化程度評分方法,嘗試為肝纖維化的動(dòng)態(tài)監(jiān)測和診斷提供定量無創(chuàng)的影像輔助手段。首先使用寬頻超聲線陣探頭獲取活體肝組織的回波RF信號多幀;顯示某幀B型圖,選取感興趣區(qū)(ROI)內(nèi)的每點(diǎn)取其所有幀RF信號構(gòu)成超聲RF時(shí)間序列。提取ROI內(nèi)RF時(shí)間序列的SMR(size measure relationship)分形維數(shù)均值和6個(gè)譜特征參數(shù),分別以特征參數(shù)的相對偏差值和Fisher判別率作作相應(yīng)特征的權(quán)值,對7個(gè)特征進(jìn)行加權(quán)求和,得到評分Score-rd和Score-fisher。對兩評分分別采用支持向量機(jī)(SVM)分類正確率和ROC曲線下面積(AUC)來評估其區(qū)分正常和肝硬化樣本的有效性,結(jié)果顯示Score-rd和Score-fisher的AUC依次為0.843、0.816,SVM分類正確率均為87.5%。說明提出的評分方法能夠有效區(qū)分正常和肝硬化組織,有望為肝纖維化程度的診斷提供定量參考。
[Abstract]:A method for evaluating the degree of hepatic fibrosis based on the time series of radiofrequency ultrasound (RF) was proposed to provide quantitative and noninvasive imaging aids for the dynamic monitoring and diagnosis of hepatic fibrosis.Firstly, wideband ultrasonic linear array probe is used to obtain multiple frames of echo RF signals from living liver tissue, and each frame RF signal of each point in the region of interest is selected to form ultrasonic RF time series.The mean fractal dimension of SMR(size measure correlation of RF time series in ROI and six spectral characteristic parameters were extracted. The relative deviation of characteristic parameters and the Fisher discriminant rate were taken as the weights of the corresponding features respectively. The weighted sum of the seven features was carried out, and the scores of Score-rd and Score-fisherwere obtained.Support vector machine (SVM) classification accuracy rate and area under ROC curve were used to evaluate the validity of the two scores in differentiating normal and cirrhosis samples. The results showed that the AUC of Score-rd and Score-fisher were 0.843 / 0.816 respectively and 87.5% respectively.The results show that the proposed scoring method can effectively distinguish normal and liver cirrhosis tissues and may provide a quantitative reference for the diagnosis of liver fibrosis.
【作者單位】： 華南理工大學(xué)電子與信息學(xué)院;中山大學(xué)附屬腫瘤醫(yī)院;
【基金】：國家自然科學(xué)基金資助項(xiàng)目(81271578)
【分類號】：R445.1;R575.2

【參考文獻(xiàn)】

相關(guān)期刊論文 前2條

1 于立友;汪龍德;;肝纖維化檢測方法的臨床研究進(jìn)展[J];甘肅中醫(yī)學(xué)院學(xué)報(bào);2013年02期

2 梁健;唐艷芳;鄧鑫;吳發(fā)勝;劉紅丹;;肝纖維化無創(chuàng)性診斷研究進(jìn)展[J];實(shí)用中醫(yī)藥雜志;2011年11期

【共引文獻(xiàn)】

相關(guān)期刊論文 前10條

1 陸倫根;;肝纖維化非創(chuàng)傷性診斷評估及其臨床應(yīng)用[J];國際消化病雜志;2013年05期

2 Han-Teng Yang;Ke-Fei Chen;Qiang Lu;Yong-Gang Wei;Bo Li;Yang Qin;Wen-Qing Huang;;Ultrasonic integrated backscatter in assessing liver steatosis before and after liver transplantation[J];Hepatobiliary & Pancreatic Diseases International;2014年04期

3 陸永萍;韋嘉;徐麗榮;湯躍躍;袁媛;張勇;李云燕;;Assessment of Fibrosis during the Development of Fatty Liver in Rabbits using Real-time Shear-wave Elastography[J];Journal of Huazhong University of Science and Technology(Medical Sciences);2014年06期

4 李曉霞;李彬;李林;李忠信;付光宇;吳學(xué)煒;;肝纖維化血清標(biāo)志物的臨床應(yīng)用評價(jià)[J];中國現(xiàn)代醫(yī)生;2012年25期

5 賈曉娟;許澤清;南永剛;袁彬;姚安梅;施常備;;肝纖四項(xiàng)在乙肝攜帶的肝癌患者血清中的表達(dá)情況[J];中外醫(yī)學(xué)研究;2013年09期

6 Xin-Wu Cui;Mireen Friedrich-Rust;Chiara De Molo;Andre Ignee;Dagmar Schreiber-Dietrich;Christoph F Dietrich;;Liver elastography, comments on EFSUMB elastography guidelines 2013[J];World Journal of Gastroenterology;2013年38期

7 Xing-Rong Hu;Xian-Nian Cui;Qi-Tuo Hu;Jun Chen;;Value of MR diffusion imaging in hepatic fibrosis and its correlations with serum indices[J];World Journal of Gastroenterology;2014年24期

8 王玲娣;巫露丹;毛衛(wèi)林;;血清學(xué)無創(chuàng)肝纖維化檢測與肝臟穿刺病理診斷的比較研究[J];中國現(xiàn)代醫(yī)生;2014年24期

9 Giada Sebastiani;Konstantinos Gkouvatsos;Kostas Pantopoulos;;Chronic hepatitis C and liver fibrosis[J];World Journal of Gastroenterology;2014年32期

10 王迪;鄭慧;李曉金;姚，

本文編號：1720754