本文選題：磁共振胰膽管成像　切入點(diǎn)：膽管　出處：《北京交通大學(xué)》2017年碩士論文

【摘要】：膽管結(jié)石在我國是一種常見的膽道系統(tǒng)疾病,現(xiàn)階段缺乏定量計算膽管形態(tài)學(xué)特征的方法,限制了特征分析在膽管結(jié)石影像學(xué)檢查結(jié)果中的應(yīng)用。本文提出了一種以 MRCP(Magnetic Resonance Cholangiopancreatography,磁共振胰膽管成像)圖像為研究對象的膽管結(jié)石三維圖像處理與形態(tài)特征定量分析方法,并初步分析了膽管形態(tài)學(xué)特征與影像學(xué)診斷結(jié)果之間的關(guān)系。本文主要完成以下兩方面工作:(1)針對手工難以實(shí)現(xiàn)膽管三維形態(tài)特征定量分析的問題,給出了一種膽管三維形態(tài)學(xué)特征參數(shù)的計算機(jī)分析方法。選取MRCP三維Dicom圖像序列,利用圖像分割、三維骨架化處理獲取膽管三維中心線,在此基礎(chǔ)上通過計算獲取膽管長度、半徑和三維曲率等形態(tài)學(xué)特征信息。通過臨床26例MRCP圖像病例驗(yàn)證,證實(shí)了該方法應(yīng)用于膽管形態(tài)學(xué)特征信息提取的可行性和有效性。(2)針對膽管三維形態(tài)學(xué)特征參數(shù)與患者臨床信息相關(guān)性分析不足的現(xiàn)狀,探討了膽管形態(tài)學(xué)特征與臨床信息的關(guān)聯(lián)性。利用箱型圖和獨(dú)立樣本t檢驗(yàn),統(tǒng)計分析膽管形態(tài)學(xué)特征參數(shù)與患者基本信息、臨床診斷情況之間的關(guān)系。在已有的臨床數(shù)據(jù)集上進(jìn)行關(guān)聯(lián)性的分析,結(jié)果表明:性別對膽管長度和曲率平均值有影響,年齡對膽管半徑最大值有影響,膽管長度和半徑最大值對結(jié)石的CT診斷結(jié)果有影響。本文利用三維圖像處理方法實(shí)現(xiàn)了膽管的形態(tài)學(xué)特征參數(shù)的定量提取,獲得了膽管形態(tài)學(xué)特征與膽管結(jié)石患者臨床數(shù)據(jù)、影像學(xué)診斷漏診情況的相關(guān)性,為進(jìn)一步開展膽結(jié)石的計算機(jī)輔助診斷研究提供了可參考的圖像處理方法和理論分析基礎(chǔ)。
[Abstract]:Choledocholithiasis is a common disease of bile duct system in China. At present, there is a lack of quantitative method to calculate the morphological characteristics of bile duct, which limits the application of feature analysis in imaging examination of bile duct stones.In this paper, a method of 3D image processing and quantitative analysis of morphologic features of cholangiopancreatography (MRCP(Magnetic Resonance cholangiopancreatography) is presented.The relationship between the morphological features of bile duct and imaging diagnosis was analyzed.In order to solve the problem that it is difficult to realize the quantitative analysis of the three-dimensional morphological characteristics of bile duct by hand, this paper presents a computer analysis method for the three-dimensional morphological characteristics of bile duct.The MRCP 3D Dicom image sequence was selected, and the three-dimensional central line of the bile duct was obtained by image segmentation and three-dimensional skeleton processing. On this basis, morphological information such as the length, radius and three-dimensional curvature of the bile duct were obtained.The feasibility and effectiveness of this method in extracting bile duct morphological feature information were confirmed by clinical MRCP images in 26 cases. (2) aiming at the lack of correlation analysis between three-dimensional morphological parameters of bile duct and clinical information of patients, the present situation of this method is proved.The relationship between the morphological features of bile duct and clinical information was discussed.The relationship between the characteristic parameters of bile duct morphology and the basic information of patients and clinical diagnosis was analyzed by using box diagram and independent sample t-test.The results of correlation analysis on existing clinical data sets showed that gender had an effect on the mean length and curvature of bile duct, age on the maximum radius of bile duct.The maximum length and radius of bile duct have influence on CT diagnosis of stone.In this paper, the quantitative extraction of the morphological parameters of bile duct was realized by using three-dimensional image processing method. The correlation between the morphological features of bile duct and clinical data of patients with cholelithiasis and the missed diagnosis of imaging diagnosis was obtained.It provides a reference image processing method and theoretical analysis basis for the further study of computer aided diagnosis of gallstones.
【學(xué)位授予單位】：北京交通大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R575.62;TP391.41

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