發(fā)布時間：2018-04-04 12:37

  本文選題：非酒精性脂肪肝　切入點：非酒精性脂肪性肝炎　出處：《河北醫(yī)科大學(xué)》2016年碩士論文

【摘要】：非酒精性脂肪肝病(NAFLD)是常見的慢性肝病。NAFLD包括一系列病理改變,從單純的脂肪變性,到非酒精性脂肪性肝炎(NASH)、肝硬化,最終可能發(fā)展為肝細胞肝癌。NASH的主要病理改變是炎癥,這其中牽涉到一系列細胞因子和趨化因子。C-X-C趨化因子10(CXCL10)是一種促炎趨化因子,它在NASH的發(fā)生、發(fā)展過程中發(fā)揮重要作用。肝內(nèi)CXCL10主要由肝細胞和肝竇內(nèi)皮細胞分泌。CXCL10與其特異性受體CXCR3結(jié)合,募集活化的CXCR3+T淋巴細胞和巨噬細胞聚集至肝實質(zhì),起到促進炎癥、細胞凋亡和纖維化的作用。血清CXCL10水平與小葉炎癥的嚴重程度相關(guān),且為NASH的獨立危險因素。CXCL10可以作為NASH的無創(chuàng)性生物標記物,并且可能是NASH的潛在的治療靶點。本文分析了CXCL10在非酒精性脂肪性肝病中的病理作用及其潛在的臨床應(yīng)用價值,為進一步CXCL10在改善NASH和相關(guān)代謝性疾病中的作用提高理論基礎(chǔ)。
[Abstract]:This involves a series of cytokines and chemokines. C-X-C chemokine 10CXCL10) is a pro-inflammatory chemokine, which plays an important role in the occurrence and development of NASH.CXCL10 in liver is mainly secreted by hepatocytes and sinusoidal endothelial cells. CXCL10 binds to its specific receptor CXCR3, and collects activated CXCR3 T lymphocytes and macrophages into the liver parenchyma, which can promote inflammation, apoptosis and fibrosis.Serum CXCL10 level is correlated with the severity of lobular inflammation and is an independent risk factor for NASH. CXCL10 can be used as a noninvasive biomarker of NASH and may be a potential therapeutic target for NASH.This paper analyzes the pathological role of CXCL10 in non-alcoholic fatty liver disease and its potential clinical application value, which is the theoretical basis for further improving the role of CXCL10 in the improvement of NASH and related metabolic diseases.
【學(xué)位授予單位】：河北醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R575.5

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相關(guān)期刊論文 前2條

1 Marianthi Papagianni;Areti Sofogianni;Konstantinos Tziomalos;;Non-invasive methods for the diagnosis of nonalcoholic fatty liver disease[J];World Journal of Hepatology;2015年04期

2 ;Expression of CXC chemokine IP-10 in patients with chronic hepatitis B[J];Hepatobiliary & Pancreatic Diseases International;2008年01期

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本文編號：1709985