本文選題：抗GP210抗體　切入點：抗SP100抗體　出處：《重慶醫(yī)科大學(xué)》2016年碩士論文　論文類型：學(xué)位論文

【摘要】：背景與目的:原發(fā)性膽汁性肝硬化(primary biliary cirrhosis,PBC)是一種慢性肝內(nèi)膽汁淤積性疾病,最終可發(fā)展為肝硬化和肝衰竭,病因尚不清楚,發(fā)病率逐年上升。PBC患者的診斷對其預(yù)后至關(guān)重要。系統(tǒng)評價抗GP210抗體和抗SP100抗體對PBC的診斷價值。方法:計算機檢索Cochrane圖書館、MEDLINE、維普中文科技期刊數(shù)據(jù)庫(VIP)、中文科技期刊全文數(shù)據(jù)庫(CNKI)、中國學(xué)位論文全文數(shù)據(jù)庫(萬方)。按文內(nèi)所述納入標準收集抗GP210抗體和抗SP100抗體診斷PBC的研究,采用QUADAS量表進行質(zhì)量評價,利用Meta-disc1.4及Rev Man5.2軟件進行數(shù)據(jù)分析,繪制SROC曲線。結(jié)果:檢索后共納入25項抗GP210抗體和21項抗SP100抗體的研究�？笹P210抗體對原發(fā)性膽汁性肝硬化的診斷優(yōu)勢比(DOR)、匯總靈敏度和匯總特異度分別是24.854(95%CI,11.957 51.660)、0.272(95%CI,0.257 0.288)和0.985(95%CI,0.982 0.988),抗SP100抗體DOR、匯總靈敏度和匯總特異度分別是9.133(95%CI,4.739 17.600)、0.231(95%CI,0.213 0.249)和0.977(95%CI,0.973 0.981)。結(jié)論:抗GP210抗體和抗SP100抗體對于原發(fā)性膽汁性肝硬化診斷特異度高,但靈敏度較低。
[Abstract]:Background & AIM: primary biliary cirrhosis of primary biliary cirrhosis is a chronic intrahepatic cholestasis disease, which can eventually develop into cirrhosis and liver failure. The diagnostic value of anti GP210 antibody and anti SP100 antibody in the diagnosis of PBC was evaluated systematically. Methods: to search Cochrane library for MEDLINE, Weipu Chinese science and technology journal database, Chinese, Chinese, etc. The full text Database of Sci-tech Journals (CNKI), the full text Database of Chinese academic dissertations (Wan Fang). The research on the diagnosis of PBC by anti GP210 antibody and anti SP100 antibody according to the inclusion standard mentioned in the paper, QUADAS scale was used for quality evaluation, and Meta-disc1.4 and Rev Man5.2 software were used for data analysis. SROC curves were drawn. Results: after retrieval, 25 anti GP210 antibodies and 21 anti SP100 antibodies were included. The diagnostic advantage of anti GP210 antibody in primary biliary cirrhosis was higher than that of GP210 antibody. The sum sensitivity and aggregation specificity of anti GP210 antibody were 24.854 5 95 CI 11.957 0. 27295 CI 0.257 0.288 respectively. The sum sensitivity and specificity of anti SP100 antibody were 9.133C95CIQ 4.739 and 17.600,0.231CI0.213 0.249and 0.97795CII 0.973 0.981.Conclusion: the specificity of anti GP210 antibody and anti SP100 antibody in the diagnosis of primary biliary cirrhosis is high, and the specificity of anti GP210 antibody and anti SP100 antibody is higher than that of anti SP100 antibody in the diagnosis of primary biliary cirrhosis, and the total sensitivity and specificity of anti SP100 antibody are 9. 133% and 0. 231 鹵0. 249, respectively. Conclusion: anti GP210 antibody and anti SP100 antibody are of high specificity in the diagnosis of primary biliary cirrhosis. But the sensitivity is low.
【學(xué)位授予單位】：重慶醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R575.22

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相關(guān)期刊論文 前1條

1 ;Primary biliary cirrhosis:What do autoantibodies tell us?[J];World Journal of Gastroenterology;2010年29期

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本文編號：1617966