本文選題：乙型肝炎病毒　切入點(diǎn)：乙肝病毒血清標(biāo)志物　出處：《華中科技大學(xué)學(xué)報(bào)(醫(yī)學(xué)版)》2017年02期 　論文類(lèi)型：期刊論文

【摘要】：目的探討外周血中乙肝病毒血清標(biāo)志物(hepatitis B virus serum markers,HBV-M)、HBV DNA載量和反映肝損傷的肝功能指標(biāo)之間的關(guān)聯(lián)性。方法回顧分析2014年3月~2016年3月同濟(jì)醫(yī)院483例慢性乙型肝炎患者資料,HBV-M采用微粒子化學(xué)發(fā)光技術(shù)定量檢測(cè);HBV DNA采用實(shí)時(shí)熒光定量PCR檢測(cè);谷丙轉(zhuǎn)氨酶(ALT)和谷草轉(zhuǎn)氨酶(AST)采用紫外連續(xù)監(jiān)測(cè)法檢測(cè)。結(jié)果 HBsAg的含量與HBV DNA載量、ALT異常比例(41U/L)和AST異常比例(35U/L)之間均無(wú)關(guān)聯(lián)性(均P0.05);HBeAg的含量與HBV DNA載量和ALT異常比例之間均無(wú)關(guān)聯(lián)性(均P0.05),但與AST異常比例有關(guān)聯(lián),關(guān)聯(lián)程度不密切(r=0.21,P0.01);抗-HBe的含量與HBV DNA載量和AST異常比例之間有關(guān)聯(lián)性,但關(guān)聯(lián)程度不密切(r=0.16,P0.05;r=0.19,P0.01),與ALT異常比例之間無(wú)關(guān)聯(lián)性(P0.05);抗-HBc的含量與HBV DNA載量、ALT異常比例和AST異常比例之間均有關(guān)聯(lián)性,但關(guān)聯(lián)程度不密切(r=0.25,P0.01;r=0.29,P0.01;r=0.29,P0.01);HBV DNA載量的對(duì)數(shù)值與ALT和AST呈正相關(guān),但線(xiàn)性相關(guān)程度較弱(r=0.24;r=0.29)。結(jié)論乙肝病毒血清標(biāo)志物定量檢測(cè)和HBV DNA定量檢測(cè),二者相互補(bǔ)充但不能取代,同時(shí)聯(lián)合肝功能各項(xiàng)指標(biāo)的檢測(cè),更有助于了解肝組織的受損程度。
[Abstract]:Objective to investigate the relationship between hepatitis B virus serum markers HBV DNA load and liver function index reflecting liver injury in peripheral blood. Methods from March 2014 to March 2016, #number0# cases of chronic hepatitis B in Tongji Hospital were retrospectively analyzed. HBV-M was quantitatively detected by microparticle chemiluminescence technique and real-time fluorescence quantitative PCR was used to detect HBV DNA. Alt and AST) were detected by UV continuous monitoring. Results there was no correlation between the HBsAg content and the abnormal ratio of alt in HBV DNA and AST at 35 U / L (both P0.05HBeAg and HBV DNA load and ALT). There was no correlation between abnormal proportions (P0.05%, P 0.05), but there was no correlation between abnormal proportions of AST, There was a correlation between anti-HBe content and HBV DNA load and AST abnormal ratio. However, the correlation degree was not close, but there was no correlation between the ratio of ALT abnormality and the level of anti-HBc, but there was a positive correlation between the content of anti-HBc and the abnormal ratio of HBV DNA load and alt and AST, but the correlation degree was not close, but the logarithmic value of DNA load of ALT was positively correlated with ALT and AST. Conclusion the quantitative detection of serum markers of hepatitis B virus and the quantitative detection of HBV DNA complement each other, but can not be replaced, and combined with the detection of various indexes of liver function, it is more helpful to understand the degree of damage to liver tissue.
【作者單位】： 華中科技大學(xué)同濟(jì)醫(yī)學(xué)院附屬同濟(jì)醫(yī)院檢驗(yàn)科;華中科技大學(xué)同濟(jì)醫(yī)學(xué)院基礎(chǔ)醫(yī)學(xué)院病原生物學(xué)系;
【分類(lèi)號(hào)】：R446.6;R512.62

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 曲俊彥;游晶;唐寶璋;;慢性乙型肝炎病毒感染者前C區(qū)變異及HBV DNA載量的臨床意義[J];國(guó)際流行病學(xué)傳染病學(xué)雜志;2006年01期

2 黃兆明;趙瑩;;HBV攜帶孕婦妊娠晚期HBV DNA載量及產(chǎn)褥期生活方式對(duì)產(chǎn)后轉(zhuǎn)氨酶的影響[J];新醫(yī)學(xué);2014年07期

3 彭建平;孫克偉;伍玉南;何芳;;慢性乙型肝炎患者外周血樹(shù)突狀細(xì)胞HBV DNA載量與其功能的關(guān)系[J];世界華人消化雜志;2008年31期

4 雷姿穎;李學(xué)俊;賴(lài)菁;黃旭明;柯偉民;高志良;;HBeAg陰性慢性乙型肝炎急性發(fā)作緩解過(guò)程MELD評(píng)分變化與HBV DNA載量的關(guān)系[J];臨床肝膽病雜志;2010年06期

5 肖艷華;易俊卿;陳偉烈;盧業(yè)成;楊湛;;慢性乙型肝炎患者病毒基因B、C分型及HBV DNA載量與肝組織病理的關(guān)系[J];廣東醫(yī)學(xué);2009年12期

6 高敏;盧誠(chéng)震;王怡;翟璐;郭潔;周莉;韓旭;劉勇鋼;;慢性HBV感染者血清HBeAg、HBV DNA載量與肝組織病理?yè)p傷的關(guān)系[J];肝臟;2010年03期

7 葉立紅;王攬，

本文編號(hào)：1617676