發(fā)布時(shí)間：2018-02-21 14:11

  本文關(guān)鍵詞： 幽門(mén)螺旋桿菌 阿莫西林 呋喃唑酮　出處：《中國(guó)老年學(xué)雜志》2017年02期 　論文類(lèi)型：期刊論文

【摘要】：目的探討含阿莫西林、呋喃唑酮四聯(lián)療法補(bǔ)救治療老年幽門(mén)螺旋桿菌感染的效果及安全性。方法前瞻性選取2011年1月至2015年6月因幽門(mén)螺旋桿菌根除治療失敗到本院就診、根據(jù)病情需要接受含阿莫西林、呋喃唑酮四聯(lián)療法補(bǔ)救根除治療的老年患者。給予蘭索拉唑30 mg,阿莫西林1 000 mg,呋喃唑酮100 mg,膠體果膠鉍200 mg,2次/d,早晚口服,療程14 d。均于治療開(kāi)始后7、14 d及治療結(jié)束4 w后進(jìn)行隨診,詳細(xì)記錄患者不良反應(yīng)和癥狀情況。療程結(jié)束4 w后采用13C-尿素呼氣試驗(yàn)檢測(cè)幽門(mén)螺旋桿菌根除情況。結(jié)果 117例入選患者中3例由于嚴(yán)重不良反應(yīng)停藥,114例完成治療,107例成功根除幽門(mén)螺旋桿菌,意向性和符合方案分析,根除率分別為93.86%和91.45%;不良反應(yīng)發(fā)生率18.42%。女性患者四聯(lián)療法補(bǔ)救治療幽門(mén)螺旋桿菌感染成功率明顯高于男性(P0.05);日常無(wú)飲酒習(xí)慣的患者補(bǔ)救治療成功率明顯高于有飲酒習(xí)慣者(P0.05)。根除幽門(mén)螺旋桿菌失敗的患者以往平均治療次數(shù)明顯高于全組平均治療次數(shù)(P0.05);合并其他疾病的患者不良反應(yīng)發(fā)生率明顯高于無(wú)合并疾病者(P0.05)。結(jié)論含阿莫西林、呋喃唑酮四聯(lián)療法14 d療程幽門(mén)螺旋桿菌根除率較高(90%),不良反應(yīng)發(fā)生率在可接受范圍內(nèi);該方案治療期間應(yīng)重視男性有飲酒習(xí)慣、多次根除治療失敗、合并其他疾病的患者。
[Abstract]:Objective to investigate the efficacy and safety of quadruple therapy with amoxicillin and furazolidone in the treatment of Helicobacter pylori infection in the elderly. Elderly patients who received remedial eradication therapy with amoxicillin and furazolidone according to their condition, were given lansoprazole 30 mg, amoxicillin 1 000 mg, furazolidone 100 mg, colloidal bismuth pectin 200 mg / d, orally orally in the morning and evening, The course of treatment was 14 days. All patients were followed up at 714 days after treatment and 4 weeks after treatment. After 4 weeks of treatment, 13C-urea breath test was used to detect the eradication of Helicobacter pylori. Results among 117 patients, 3 patients stopped taking drugs because of severe adverse reactions. 107 cases of Helicobacter pylori were successfully eradicated. Analysis of intentionality and conformity, The rates of eradication were 93.86% and 91.45, respectively. The incidence of adverse reactions was 18.42. The success rate of treatment of Helicobacter pylori infection in female patients was significantly higher than that in men (P 0.05), and the success rate in patients with daily drinking habits was significantly higher than that in patients with drinking. The average times of treatment in patients with failed eradication of Helicobacter pylori in the past were significantly higher than those in the whole group, and the incidence of adverse reactions in patients with other diseases was significantly higher than that in patients without other diseases. The eradication rate of Helicobacter pylori was higher than that of furazolidone quadruple therapy for 14 days, and the incidence of adverse reactions was within the acceptable range. During the course of the treatment, attention should be paid to the men who had the habit of drinking, the failure of multiple eradication treatments and the patients with other diseases.
【作者單位】： 南京工業(yè)大學(xué);
【分類(lèi)號(hào)】：R573.1

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