本文關(guān)鍵詞： 連續(xù)性血液凈化 重癥急性胰腺炎 腎素-血管緊張素-醛固酮系統(tǒng) 炎癥因子　出處：《中國老年學(xué)雜志》2015年03期 　論文類型：期刊論文

【摘要】：目的探討連續(xù)性血液凈化對(duì)重癥急性胰腺炎患者腎素-血管緊張素-醛固酮系統(tǒng)(RAAS)及炎癥因子的影響。方法收集該院ICU 2010年6月至2014年6月診治的重癥急性胰腺炎患者100例,按照隨機(jī)數(shù)字表法分為觀察組和對(duì)照組各50例,兩組均給予常規(guī)治療,觀察組在常規(guī)治療的基礎(chǔ)上給予連續(xù)性血液凈化治療,觀察兩組治療效果以及對(duì)RAAS及炎性指標(biāo)的影響。結(jié)果經(jīng)過3 d時(shí)間治療,觀察組急性生理和慢性健康(APACHE)Ⅱ評(píng)分、腹痛緩解時(shí)間、住院時(shí)間明顯低于對(duì)照組(P0.05),觀察組并發(fā)癥和死亡病例比例分別為14.0%、12.0%,明顯低于對(duì)照組的42.0%、36.0%(P0.05);RAAS指標(biāo)血管緊張素(Ang)-Ⅰ、Ang-Ⅱ、腎素(E)、醛固酮(ALD)水平在兩組均為下降趨勢(shì),各項(xiàng)指標(biāo)經(jīng)過方差分析P0.05。Ang-I、Ang-Ⅱ、E、ALD等指標(biāo)治療前兩組差異均無統(tǒng)計(jì)學(xué)意義(P0.05),治療1、3 d觀察組明顯低于對(duì)照組(P0.05);炎癥指標(biāo)腫瘤壞死因子(TNF)-α、白細(xì)胞介素(IL)-1β、IL-6、IL-8水平在兩組均為下降趨勢(shì),各項(xiàng)指標(biāo)經(jīng)過方差分析P0.05。TNF-α、IL-1β、IL-6、IL-8等指標(biāo)治療前兩組差異均無統(tǒng)計(jì)學(xué)意義(P0.05),在治療1、3 d測(cè)定TNF-α、IL-1β、IL-6、IL-8水平,觀察組的水平明顯低于對(duì)照組(P0.05)。結(jié)論連續(xù)性血液凈化對(duì)重癥急性胰腺炎患者治療效果明顯,可以明顯改善RAAS及炎性因子指標(biāo)。
[Abstract]:Objective to investigate the effects of continuous blood purification on renin-angiotensin-aldosterone system (Ras) and inflammatory factors in patients with severe acute pancreatitis (SAP). According to the method of random digital table, the two groups were divided into two groups: the observation group (n = 50) and the control group (n = 50). Both groups were given routine treatment, and the observation group was given continuous blood purification therapy on the basis of routine treatment. Results after 3 days of treatment, the acute physiological and chronic health of the observation group were assessed with Apache 鈪，

本文編號(hào)：1495373