本文關(guān)鍵詞：血清鋅α2糖蛋白水平與非酒精性脂肪肝的相關(guān)性分析　出處：《南華大學(xué)》2016年碩士論文　論文類型：學(xué)位論文

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【摘要】：目的:觀察肥胖及非酒精性脂肪性肝病患者血清鋅alpha2糖蛋白(Zinc alpha2 glycoprotein,ZAG)水平及其與人體測量學(xué)、脂質(zhì)代謝、糖類代謝、胰島素抵抗等多項指標的關(guān)系,分析和探討ZAG與體重的關(guān)系及其在脂質(zhì)代謝中的作用。對象及方法:1.根據(jù)有無非酒精性脂肪肝和體重指數(shù)(BMI),經(jīng)篩選后將研究對象分為:健康對照組(Control-18.5≤BMI24kg/m2)144例,超重無非酒精性脂肪性肝病組(Control-24≤BMI28kg/m2)58例,肥胖無非酒精性脂肪性肝病組(Control-BMI≥28kg/m2)10例,BMI正常的非酒精性脂肪性肝病組(NAFLD-18.5≤BMI24kg/m2)29例,超重非酒精性脂肪性肝病組(NAFLD-24≤BMI28kg/m2)77例,肥胖非酒精性脂肪性肝病組(NAFLD-BMI≥28kg/m2)30例。2.采用自動生化儀檢測甘油三脂(TG)、總膽固醇(TC)、高密度脂蛋白膽固醇(HDL-C)、低密度脂蛋白膽固醇(LDL-C)、谷丙轉(zhuǎn)氨酶(ALT)、谷草轉(zhuǎn)氨酶(AST)、谷胺酰轉(zhuǎn)肽酶(GGT)、C反應(yīng)蛋白(CRP)、尿酸(UA)、空腹胰島素(FINS);測量收縮壓(SBP)、舒張壓(DBP)、身高(Ht)、體重(Wt)、腰圍(WC)、臀圍(HC);計算腰圍身高比(WHtR)、腰臀比(WHR)、身體質(zhì)量指數(shù)(BMI)、胰島素抵抗指數(shù)(HOMA-IR)、體內(nèi)脂肪含量(Fat%)、脂質(zhì)沉積產(chǎn)物(lap)和內(nèi)臟脂肪指數(shù)(vai)。3.從上述標本中隨機抽取樣本79例,根據(jù)有無非酒精性脂肪肝和體重指數(shù)(bmi)將研究對象細分為:健康對照組(control-18.5≤bmi24kg/m2)12例,超重無非酒精性脂肪性肝病組(control-24≤bmi28kg/m2)9例,肥胖無非酒精性脂肪性肝病組(control-bmi≥28kg/m2)3例,bmi正常的非酒精性脂肪性肝病組(nafld-18.5≤bmi24kg/m2)13例,超重非酒精性脂肪性肝病組(nafld-24≤bmi28kg/m2)19例,肥胖非酒精性脂肪性肝病組(nafld-bmi≥28kg/m2)23例;懫用elisa法檢測空腹狀態(tài)下血清zag及脂聯(lián)素水平。4.應(yīng)用統(tǒng)計學(xué)方法比較各組血清zag水平及其與其他指標的相關(guān)性。結(jié)果:1.control-18.5≤bmi24kg/m2組、control-24≤bmi28kg/m2組、control-bmi≥28kg/m2組、nafld-18.5≤bmi24kg/m2組、nafld-24≤bmi28kg/m2組、nafld-bmi≥28kg/m2組血清zag水平分別為35.14±10.87μg/ml、28.40±10.10μg/ml、19.02±13.06μg/ml、26.89±7.73μg/ml、27.99±4.95μg/ml、31.13±13.38μg/ml;在18.5≤bmi24kg/m2時,nafld組zag的血清水平低于對照組(p=0.046);在對照組中,bmi≥28kg/m2組較18.5≤bmi24kg/m2組的zag血清水平低(p=0.016)。2.血清zag水平與dbp、fpg、insulin、homa-ir呈負相關(guān)(p0.05);在NAFLD組中,血清ZAG水平與年齡呈正相關(guān)(P0.05)血清ZAG水平與Insulin、HOMA-IR呈負相關(guān)(P0.05);在對照組中,血清ZAG水平不僅與SBP、DBP呈負相關(guān)(P0.05),也與Insulin、HOMA-IR及Fat%呈負相關(guān)(P0.01)。結(jié)論:NAFLD患者血清中ZAG水平與Insulin、HOMA-IR呈負相關(guān),ZAG的血清水平隨著BMI的增加而上升。
[Abstract]:Objective: To observe the effects of obesity and nonalcoholic fatty liver disease serum zinc alpha2 glycoprotein (Zinc alpha2 glycoprotein, ZAG) levels and anthropometric, lipid metabolism, carbohydrate metabolism, insulin resistance and many other indicators, analyze and discuss the relationship of ZAG and body weight and its role in lipid metabolism. Subjects and methods: 1. according to the compare of alcoholic fatty liver and body mass index (BMI), the selected subjects were divided into healthy control group (Control-18.5 = BMI24kg/m2) and 144 cases of overweight, no alcoholic fatty liver disease group (Control-24 = BMI28kg/m2) and 58 cases of obesity, no alcoholic fatty liver disease group (Control-BMI = 28kg/m2) 10 cases of normal BMI groups of non-alcoholic fatty liver disease (NAFLD-18.5 = BMI24kg/m2) and 29 cases of overweight, nonalcoholic fatty liver disease group (NAFLD-24 = BMI28kg/m2) and 77 cases of obesity, nonalcoholic fatty liver disease group (NAFLD -BMI鈮，

本文編號：1397348