背景:干眼（dry eye,DED）是一種常見(jiàn)的眼部疾病。干眼需要及時(shí)的診斷和治療,否則會(huì)導(dǎo)致危及視力的并發(fā)癥,如角膜潰瘍,角膜瘢痕、變薄,甚至角膜穿孔。早期診斷和治療非常關(guān)鍵,可以防止并發(fā)癥的產(chǎn)生,提高視覺(jué)質(zhì)量。瞼板腺是位于眼瞼的大型皮脂腺,能夠分泌脂質(zhì),形成淚膜表層,減少水分蒸發(fā)。上眼瞼約有25-40個(gè)腺體,長(zhǎng)約5.5毫米;下眼瞼約有20-30個(gè)腺體,長(zhǎng)約2毫米。瞼板腺將脂質(zhì)合成并分泌到淚膜中形成脂質(zhì)層,這對(duì)于防止水液的過(guò)度蒸發(fā)至關(guān)重要。瞼板腺功能障礙（meibomain gland dysfunction,MGD）是一種慢性彌漫性的瞼板腺異常,包括末梢導(dǎo)管阻塞和/或腺體分泌的質(zhì)/量變化,是干眼最常見(jiàn)的原因之一。強(qiáng)脈沖光（intense pulsed light,IPL）是一種非激光的高強(qiáng)度光源,大多數(shù)現(xiàn)代設(shè)備產(chǎn)生的光脈沖是通過(guò)充氙氣室的電流脈沖產(chǎn)生的,而IPL是使用高性能氙燈產(chǎn)生長(zhǎng)波長(zhǎng)（通常在500到1200納米范圍內(nèi)）的非相干光輸出。IPL在醫(yī)學(xué)領(lǐng)域的應(yīng)用依賴于特定的能量吸收目標(biāo)（發(fā)色團(tuán)）能夠從這一寬光譜的光波長(zhǎng)（吸收帶）吸收能量。其工作原理基于選擇性的光熱效應(yīng),熱介導(dǎo)的輻射損... 

【文章來(lái)源】：吉林大學(xué)吉林省 211工程院校 985工程院校 教育部直屬院校

【文章頁(yè)數(shù)】：84 頁(yè)

【學(xué)位級(jí)別】：碩士

【文章目錄】：
中文摘要
abstract
CHAPTER 1: INTRODUCTION
    1.1 BACKGROUND
        1.1.1 Meibomian Gland Dysfunction
    1.2 RISK FACTOR
    1.3 MECHANISM OF ACTION
    1.4 CLASSIFICATION
    1.5 TEAR FILM
    1.6 PATHOPHYSIOLOGY
    1.7 MANAGEMENT
    1.8 COMPLICATIONS
CHAPTER 2: A LITERATURE REVIEW
    2.1 MECHANISMS OF ACTION OF IPL
        2.1.1 Thrombosis of abnormal blood vessels
        2.1.2 Eradication of Demodex and reducing the bacterial load
        2.1.3 Photomodulation
        2.1.4 Effects on meibum
        2.1.5 Effects on pro- and anti-inflammatory molecules andsuppression of MMPs
        2.1.6 IPL induces hypoxic condition on meibomian gland
    2.2 IPL ASSOCIATED BENEFITS
        2.2.1 Intense pulsed light in patients with refractory meibomiangland dysfunction
        2.2.2 IPL as a safe procedure for MGD
        2.2.3 Significant improvement in the first IPL treatment
        2.2.4 Effect of intense pulsed light therapy on tear proteins, lipids,and inflammatory markers in MGD
        2.2.5 Effect on the meibum of MGD by IPL
CHAPTER 3: MATERIAL AND METHODS
    3.1 OBJECTIVE OF THE STUDY
    3.2 STUDY DESIGN
    3.3 METHODS
    3.4 DIAGNOSTIC CRITERIA FOR DRY EYE
    3.5 INCLUSION CRITERIA
    3.6 EXCLUSION CRITERIA
    3.7 THERAPY PROCEDURE
    3.8 STATISTICAL ANALYSIS
CHAPTER 4: RESULT
    4.1 BASELINE CHARACTERISTICS
    4.2 COMPARISON OF MEASUREMENT IN THE LEFT EYE AND RIGHT EYEWITH BEFORE AND AFTER IPL-MGX TREATMENTS
    4.3 COMPARISON OF MEASUREMENT ACCOUNTING FOR THE CORRELATION OF THE LEFT EYE AND THE RIGHT EYE OF THE SAMEPERSON USING A GENERALIZED ESTIMATING EQUATION
    4.4 COMPARISON OF A PORTION OF THE MEIBOMIAN GLAND ACCOUNTING FOR THE UPPER AND LOWER EYELID AND THE LEFT ANDTHE RIGHT EYE OF THE SAME PATIENT
    4.5 DESCRIPTION OF RESULT
CHAPTER 5: DISCUSSION
CHAPTER 6: CONCLUSION
REFERENCE
AUTHOR’S INTRODUCTION
ACKNOWLEDGEMENT



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