【摘要】：目的探討鼓室注射地塞米松對(duì)老年分泌性中耳炎(SOM)激素骨膜穿刺術(shù)患者血清炎性因子、免疫功能及聽(tīng)力恢復(fù)的影響。方法老年SOM患者146例,采用隨機(jī)數(shù)字表法分為觀察組和對(duì)照組各73例。對(duì)照組采取鼓膜穿刺術(shù)治療,觀察組采取鼓膜穿刺術(shù)聯(lián)合鼓室注射糖皮質(zhì)激素治療,比較兩組血清炎性因子、免疫功能、聽(tīng)覺(jué)閾值、臨床療效。結(jié)果治療1個(gè)月后,觀察組有效率明顯高于對(duì)照組(χ~2=10.860,P0.01);血清內(nèi)皮素(ET)-1、腫瘤壞死因子(TNF)-α、γ-干擾素(INF-γ)含量明顯低于對(duì)照組(P0.05);T淋巴細(xì)胞亞群CD3~+、CD4~+、CD4~+/CD8~+均明顯高于對(duì)照組(P0.05);500、1 000、2 000 Hz等聽(tīng)閾值明顯低于對(duì)照組(P0.001)。結(jié)論鼓室注射地塞米松有助于緩解老年SOM彭膜穿刺術(shù)患者血清炎性因子表達(dá)水平,改善免疫功能,提高聽(tīng)力水平。
[Abstract]:Objective to investigate the effect of tympanic injection of dexamethasone on serum inflammatory factors, immune function and hearing recovery in elderly patients with secretory otitis media treated with (SOM) hormone periosteum puncture. Methods 146 elderly patients with SOM were randomly divided into observation group (n = 73) and control group (n = 73). The control group was treated with tympanic membrane puncture, and the observation group was treated with tympanic membrane puncture combined with tympanic injection of glucocorticoid. The serum inflammatory factors, immune function, auditory threshold and clinical efficacy were compared between the two groups. Results after one month of treatment, the effective rate in the observation group was significantly higher than that in the control group (蠂 ~ 2 鈮，

本文編號(hào)：2476971