小兒腺樣體肥大與抗生素應(yīng)用的相關(guān)性研究
發(fā)布時(shí)間：2019-04-21 22:01
【摘要】：目的：探討小兒腺樣體肥大的發(fā)病率呈上升趨勢是否與抗生素的不合理應(yīng)用有關(guān)系。 方法：通過我院的病案查詢系統(tǒng)統(tǒng)計(jì)近10年來每年我科收治的小兒腺樣體肥大患兒的例數(shù)，并列表進(jìn)行比較；回顧性分析統(tǒng)計(jì)實(shí)驗(yàn)組和對照組的幼兒的使用抗生素次數(shù)，進(jìn)行統(tǒng)計(jì)學(xué)分析；并對實(shí)驗(yàn)組腺樣體肥大伴有分泌性中耳炎、扁桃體肥大及術(shù)后復(fù)發(fā)等情況分別計(jì)數(shù)統(tǒng)計(jì)。 結(jié)果：1、我科（吉林大學(xué)第一醫(yī)院耳鼻咽喉-頭頸外科）近10年小兒腺樣體肥大住院手術(shù)治療例數(shù)分別為：2002年48例、2003年62例、2004年127例、2005年174例、2006年209例、2007年358例、2008年350例、2009年411例、2010年408例、2011年415例。2、在吉林大學(xué)第一醫(yī)院耳鼻咽喉頭頸外科2011年01月-2011年12月共收治的415例腺樣體肥大的手術(shù)患者中隨意抽取200例2-8歲患兒為實(shí)驗(yàn)組（其中66個(gè)女孩，134個(gè)男孩，平均年齡4.65歲），其中腺樣體肥大的程度均堵塞后鼻孔1/2以上，其中2例為術(shù)后復(fù)發(fā)患兒，同時(shí)伴有分泌性中耳炎的有44例（占22㳠），同時(shí)伴有扁桃體肥大的并手術(shù)切除的有180例（占90㳠）。3、在吉林大學(xué)附屬第三幼兒園和東北師范大學(xué)附屬小學(xué)隨機(jī)抽取完全沒有腺樣體肥大臨床癥狀的200例2-8歲幼兒為對照組（其中73個(gè)女孩，127個(gè)男孩，平均年齡4.495歲）。4、分別列出兩組年平均使用抗生素次數(shù)的頻數(shù)分布表和頻數(shù)分布圖，以便更利于直觀觀察，從上述中得出：實(shí)驗(yàn)組200例患兒年平均使用抗生素次數(shù)的均數(shù)為2.4725，，標(biāo)準(zhǔn)差1.0，對照組200例幼兒年平均使用抗生素次數(shù)的均數(shù)為0.992，標(biāo)準(zhǔn)差0.57。采用大樣本均數(shù)的假設(shè)檢驗(yàn)（u檢驗(yàn)）分析兩組間年平均使用抗生素次數(shù)的差別。ａ=0.05，P＜0.05表示有統(tǒng)計(jì)學(xué)意義。得出P＜0.01，有統(tǒng)計(jì)學(xué)意義。 結(jié)論：小兒腺樣體肥大發(fā)病率呈上升趨勢；小兒腺樣體肥大患兒大部分伴有扁桃體肥大；小兒腺樣體肥大的發(fā)病可能與抗生素應(yīng)用不合理有關(guān)。
[Abstract]:Objective: to investigate whether the incidence of adenoid hypertrophy in children is related to the unreasonable use of antibiotics. Methods: the cases of children with adenoid hypertrophy admitted to our department in recent 10 years were counted by the medical record inquiry system in our hospital, and compared with each other. The times of antibiotics used in children in the experimental group and the control group were analyzed retrospectively, and the adenoid hypertrophy with secretory otitis media, tonsillar hypertrophy and postoperative recurrence were counted respectively in the experimental group. Results: 1. There were 48 cases of adenoid hypertrophy in children in 2002, 62 cases in 2003, 127 cases in 2004, 174 cases in 2005 and 209 cases in 2006 in our department (otorhinolaryngology-head-neck surgery, first Hospital of Jilin University). 358 cases in 2007, 350 cases in 2008, 411 cases in 2009, 408 cases in 2010 and 415 cases in 2011, From January 2011 to December 2011, 200 2-8-year-old children (66 girls and 134 boys) were randomly selected from 415 patients with adenoid hypertrophy in the department of otorhinolaryngology, head and neck surgery, first Hospital, Jilin University. The average age was 4.65 years old, and the degree of adenoid hypertrophy was more than 1 ~ 2 years old. Among them, 2 cases were recurrent children and 44 cases (22%) were accompanied by secretory otitis media. At the same time, 180 cases (90%) had tonsillectomy and tonsillectomy. In the third kindergarten affiliated to Jilin University and the affiliated primary school of Northeast normal University, 200 2-year-old 8-year-old children without clinical symptoms of adenoid hypertrophy were randomly selected as control group (73 girls and 127 boys). The average age was 4.495 years old (4.4), and the frequency distribution table and frequency distribution map of the average number of antibiotics used in the two groups were set out, respectively, in order to facilitate the visual observation. The results showed that the average number of antibiotics used in the experimental group was 2.4725, the standard deviation was 1.0, and that in the control group was 0.992, and the standard deviation was 0.57. The results showed that the average number of antibiotics used in the experimental group was 2.4725 and the standard deviation was 1.0 in the control group. A = 0.05, P < 0.05 (P < 0.05) was used to analyze the difference of the average number of antibiotics used between the two groups (P < 0.05), using the hypothesis test of large sample mean (u test) to analyze the difference between the two groups. P < 0.01, with statistical significance. Conclusion: the incidence of adenoid hypertrophy in children is increasing, the majority of children with adenoid hypertrophy are associated with tonsillar hypertrophy, and the incidence of adenoid hypertrophy in children may be related to the unreasonable use of antibiotics.
【學(xué)位授予單位】：吉林大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2012
【分類號】：R766
本文編號：2462595
[Abstract]:Objective: to investigate whether the incidence of adenoid hypertrophy in children is related to the unreasonable use of antibiotics. Methods: the cases of children with adenoid hypertrophy admitted to our department in recent 10 years were counted by the medical record inquiry system in our hospital, and compared with each other. The times of antibiotics used in children in the experimental group and the control group were analyzed retrospectively, and the adenoid hypertrophy with secretory otitis media, tonsillar hypertrophy and postoperative recurrence were counted respectively in the experimental group. Results: 1. There were 48 cases of adenoid hypertrophy in children in 2002, 62 cases in 2003, 127 cases in 2004, 174 cases in 2005 and 209 cases in 2006 in our department (otorhinolaryngology-head-neck surgery, first Hospital of Jilin University). 358 cases in 2007, 350 cases in 2008, 411 cases in 2009, 408 cases in 2010 and 415 cases in 2011, From January 2011 to December 2011, 200 2-8-year-old children (66 girls and 134 boys) were randomly selected from 415 patients with adenoid hypertrophy in the department of otorhinolaryngology, head and neck surgery, first Hospital, Jilin University. The average age was 4.65 years old, and the degree of adenoid hypertrophy was more than 1 ~ 2 years old. Among them, 2 cases were recurrent children and 44 cases (22%) were accompanied by secretory otitis media. At the same time, 180 cases (90%) had tonsillectomy and tonsillectomy. In the third kindergarten affiliated to Jilin University and the affiliated primary school of Northeast normal University, 200 2-year-old 8-year-old children without clinical symptoms of adenoid hypertrophy were randomly selected as control group (73 girls and 127 boys). The average age was 4.495 years old (4.4), and the frequency distribution table and frequency distribution map of the average number of antibiotics used in the two groups were set out, respectively, in order to facilitate the visual observation. The results showed that the average number of antibiotics used in the experimental group was 2.4725, the standard deviation was 1.0, and that in the control group was 0.992, and the standard deviation was 0.57. The results showed that the average number of antibiotics used in the experimental group was 2.4725 and the standard deviation was 1.0 in the control group. A = 0.05, P < 0.05 (P < 0.05) was used to analyze the difference of the average number of antibiotics used between the two groups (P < 0.05), using the hypothesis test of large sample mean (u test) to analyze the difference between the two groups. P < 0.01, with statistical significance. Conclusion: the incidence of adenoid hypertrophy in children is increasing, the majority of children with adenoid hypertrophy are associated with tonsillar hypertrophy, and the incidence of adenoid hypertrophy in children may be related to the unreasonable use of antibiotics.
【學(xué)位授予單位】：吉林大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2012
【分類號】：R766
【參考文獻(xiàn)】
相關(guān)期刊論文 前1條
1 劉巨波;劉麗亞;謝民強(qiáng);馮志堅(jiān);魯翔;李獻(xiàn)華;洪奕純;常燕群;余力;;鼻內(nèi)鏡下腺樣體形態(tài)學(xué)研究及臨床意義[J];中華耳鼻咽喉頭頸外科雜志;2007年06期
本文編號：2462595
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