磷酸肌酸鈉治療Leber遺傳性視神經(jīng)病變的初步臨床觀察
[Abstract]:Objective to observe the efficacy of sodium phosphate in the treatment of Leber hereditary optic neuropathy (LHON). Design retrospective case series. From January 2014 to January 2016, 19 LHON patients were diagnosed in Wuhan Tongji Hospital. The patients were divided into two groups according to whether they agreed to be treated in hospital, 10 inpatients as treatment group and 9 out-patient as control group. Methods Ten LHON patients in the treatment group were treated with sodium phosphate for 7 days, twice a day, 1 g each time, injected intravenously with 250 ml normal saline for 7 days. The visual acuity and visual field before and after treatment were observed. In the control group, 9 patients were untreated and 19 patients were followed up for 1 year. Main outcome measures: visual acuity, visual field. Results after 7 days of treatment, the visual acuity of 3 patients (right eye No. 1, right eye No. 6, left eye No. 7) in the treatment group was improved by 0.3 LogMAR,0.4 LogMAR,0.7 LogMAR. respectively. After 1-year follow-up, the visual acuity of No. 1 right eye decreased, and the visual acuity of No. 6 and No. 7 did not change. Of the 3 patients, 2 (6 and 7) had 14484 point mutation and 1 (1) had 11778 point mutation. The visual field (VFI) and the visual field (MD) of 10 patients had no significant difference before and after treatment (P < 0. 167, 0. 20). There was no change in visual acuity in 9 patients who had not been treated for 1 year. Conclusion the treatment of Leber's hereditary optic neuropathy with sodium phosphate may be effective in improving or stabilizing the visual acuity of the patients with point mutation at position 14484.
【作者單位】: 華中科技大學(xué)同濟(jì)醫(yī)學(xué)院附屬同濟(jì)醫(yī)院眼科;鄂州市第五醫(yī)院藥劑科;鄂州市第五醫(yī)院超聲科;
【分類號(hào)】:R774.6
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